ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Xenoreactive antibodies"

  • 2020 American Transplant Congress

    Old World Monkeys Are Not Ideal Transplantation Models for Testing CMAHKO (TKO or GTKO/CMAHKO) Pig Kidneys

    T. Yamamoto1, H. Iwase1, D. Patel1, A. Jagdale1, J. Foote1, D. Ayares2, D. Anderson1, D. E. Eckhoff1, D. K. Cooper1, H. Hara1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Triple-knockout (TKO) pigs are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural…
  • 2020 American Transplant Congress

    Normothermic Machine Perfusion of Genetically Modified Pig Livers with Human Blood

    D. Detelich1, T. M. Coe2, C. G. Rickert2, C. Carroll2, N. Serifis2, R. Matheson2, I. Rosales2, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, S. Kimura2, A. Azimzadeh2, L. Yang3, J. F. Markmann2

    1Tufts Medical Center, Boston, MA, 2Massachusetts General Hospital, Boston, MA, 3eGenesis, Cambridge, MA

    *Purpose: Barriers to pig-to-human liver xenotransplantation remain, including profound thrombocytopenia, coagulopathy, and rejection. We utilized ex-vivo liver xenoperfusion with human blood to study the human…
  • 2020 American Transplant Congress

    Pig-To-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine

    D. Detelich1, C. G. Rickert1, T. M. Coe1, S. Kimura1, I. Rosales1, H. Deng1, H. Yeh1, W. Qin2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, J. F. Markmann1

    1Massachusetts General Hospital, Boston, MA, 2eGenesis, Cambridge, MA

    *Purpose: Pig-to-baboon liver xenotransplant (LXT) continues with significant hurdles, including thrombocytopenia, coagulation dysregulation and rejection with the longest reported survival of 29 days utilizing a…
  • 2020 American Transplant Congress

    Successful Long-Term TMA- and Rejection- Free Survival of a Kidney Xenograft with Triple Xenoantigen Knockout Plus Insertion of Multiple Human Transgenes

    D. H. Ma1, H. Sasaki1, T. Hirose1, I. Rosales1, A. Dehnadi1, R. Colvin1, J. F. Markmann1, W. Win2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, T. Kawai1

    1Surgery, MGH, Boston, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Recent advances in genome engineering technology allow for the generation of porcine organ donors with multiplex gene edits. Here we evaluated survival of kidneys…
  • 2020 American Transplant Congress

    Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses

    B. P. Lovasik1, A. J. Matar1, D. A. Faber1, D. V. Mathews1, C. P. Breeden1, S. C. Kim1, A. J. Tector2, A. B. Adams1

    1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL

    *Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…
  • 2020 American Transplant Congress

    Novel Technique to Analyze Blood-Endothelial Cell Interactions Under Flow Conditions

    M. R. Connolly1, K. Petitpas1, L. Burdorf1, B. Cerel1, C. Laird2, D. Harris2, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2University of Maryland, Baltimore, Baltimore, MD

    *Purpose: The Bioflux system has been used to study platelet-driven thrombosis and leukocyte adhesion. Typically, whole blood is stained with calcein (green) to evaluate platelet…
  • 2019 American Transplant Congress

    Absence of Antibodies in Human Neonates and Infants to Gtko/cmahko/β4galnt2ko (Triple Gene Knockout) Pig Cells: Relevance to Cardiac Xenotransplantation for Complex Congenital Heart Disease

    H. Hara1, Q. Li1, C. A. Banks1, T. Yamamoto1, D. Ayares2, D. C. Cleveland1, D. K. Cooper1

    1Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor Inc., Blacksburg, VA

    *Purpose: Heart transplantation (Tx) in neonates is associated with the best results of any organ Tx, but the lack of deceased human donor hearts in…
  • 2019 American Transplant Congress

    The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?

    T. Yamamoto1, Q. Li1, A. Banks1, H. Iwase1, D. Ayares2, D. K. Cooper1, H. Hara1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Xenoreactive antibodies and complement play an important role in pig xenograft rejection. Intravenous immunoglobulin (IVIG) is widely used in desensitization protocols and for the…
  • 2019 American Transplant Congress

    α -1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.

    J. Yoon, B. Ezekian, M. Manook, J. Kwun, S. Knechtle

    Duke Transplant Center, Durham, NC

    *Purpose: Previously, we observed that sera from rhesus macaques contained preformed antibodies against wild type (WT) swine splenocytes. In the context of xenotransplantation, preformed xenoantibodies…
  • 2019 American Transplant Congress

    Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion

    B. M. Cerel1, B. M. French2, D. G. Harris2, C. Laird2, L. Burdorf1, X. Cheng2, C. Feng3, A. S. Cross4, S. E. Goldblum4, G. R. Vasta3, R. N. Pierson III1, A. M. Azimzadeh1

    1Deparment of Surgery, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 3Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, MD, 4Department of Medicine Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Immediate neutrophil sequestration occurs despite genetic modifications (Gal-a-1-3 galactosyl transferase knock out; human CD46 complement regulatory gene addition) to pig donor organs. Sialic acids…
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