2022 American Transplant Congress
Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…2022 American Transplant Congress
Prolonged Xeno-Kidney Graft Survival in Highly Allo-Sensitized Nonhuman Primate Using Triple-Knockout Donor Pigs with 7 Human Transgenes
*Purpose: We have previously shown using porcine kidneys from genetically modified knockout alpha 1,3-galactosyltransferase (GGTA1KO) and human decay accelerating factor transgenic (CD55Tg) pigs that compared…2022 American Transplant Congress
First Report of Xenotransplantation from a Pig to Human Recipient
1NYU Langone Transplant Institute, New York, NY, 2CUMC, New York, NY
*Purpose: Xenotransplantation of genetically edited pig organs into human recipients can solve the global scarcity of organs for transplantation. Humans lack the α1,3-Gal glycan ubiquitously…2022 American Transplant Congress
Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient
Transplant Institute, NYU Langone Transplant Institute, New York, NY
*Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…2022 American Transplant Congress
First-in-Human Clinical-Grade Porcine Kidney Xenotransplant
*Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…2022 American Transplant Congress
Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours
*Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…2022 American Transplant Congress
Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease
*Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…2022 American Transplant Congress
Post-Xenotransplant Antibody Specificities Against Swine, Monkey and Human Leukocyte Antigens in Highly Sensitized Nonhuman Primate Model
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Xenotransplantation has been proposed as a bridge to transplant for allosensitized patients. However, the potential of xenotransplantation to broaden HLA allosensitization due to MHC…2022 American Transplant Congress
Pre-Transplantation Liver Immunoadsorption Reduces Liver-Specific Antibody and Complement Deposition without Prolonging Survival in Porcine to Baboon Liver Xenotransplantation
1Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2eGenesis, Inc, Cambridge, MA
*Purpose: Triple knock-out pigs lacking GGTA1, β4GALNT2, CMAH genes are hypothesized to be the optimal donor for human xenotransplantation, however there is evidence that TKO…
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