ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Xenoreactive antibodies"

  • 2022 American Transplant Congress

    First-in-Human Clinical-Grade Porcine Kidney Xenotransplant

    J. E. Locke1, B. Orandi1, V. Kumar1, J. Houp1, D. Anderson1, V. Hauptfeld1, D. Martin2, C. Killian1, S. Macedon1, N. Budd1, K. Stegner1, A. Dandro3, M. Kokkinaki3, K. Kuravi3, R. Reed4, H. Fatima1, G. Baker1, J. Perry1, E. Bryant1, M. Cheung1, E. Erman1, K. Kraebber1, T. Gamblin1, L. Guy1, D. Ayares3, P. Porrett1

    1University of Alabama at Birmingham, Birmingham, AL, 2Deakin University, Geelong, Australia, 3Revivicor, Incorporated, Blacksburg, VA, 4University of Alabama at Birmingham, Irondale, AL

    *Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…
  • 2022 American Transplant Congress

    Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours

    W. K. Wu1, R. Ukita2, Y. J. Patel2, I. A. Ziogas3, M. Cortelli2, M. Mentz2, J. R. Talackine2, S. A. Francois2, N. L. Cardwell2, J. W. Stokes2, S. P. Alexopoulos3, M. Bacchetta2

    1Hepatobiliary Surgery and Liver Transplantation; Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, 2Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, 3Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…
  • 2022 American Transplant Congress

    Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants

    B. Keating1, B. Piening2, M. Mangiola3, J. Stern4, W. Zhang5, A. Griesemer6, B. Lonze7, M. Snyder8, J. Boeke5, R. Montgomery7

    1University of Pennsylvania, Philadelphia, PA, 2Providence Cancer Center, Portland, OR, 3New York University Langone Medical Center, New York, NY, 4Department of Surgery, NYU Langone, New York, NY, 5Institute of Systems Genetics, NYU Langone, New York, NY, 6Surgery, NYU Langone, New York, NY, 7NYU Langone Transplant Institute, New York, NY, 8Genetics, Stanford, Palo Alto, CA

    *Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
  • 2022 American Transplant Congress

    Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease

    T. Yamamoto1, M. H. Bikhet2, H. Q. Nguyen2, Y. Cui2, M. Javed2, S. S. Raza2, D. Ayares3, H. Iwase2, H. Hara2, D. K. Cooper1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 3Revivicor, Blacksburg, VA

    *Purpose: Blood transfusion remains important in the treatment of patients with sickle cell disease (SCD). However, alloimmunization after multiple blood transfusions is associated with patient…
  • 2022 American Transplant Congress

    Post-Xenotransplant Antibody Specificities Against Swine, Monkey and Human Leukocyte Antigens in Highly Sensitized Nonhuman Primate Model

    I. DeLaura, I. Anwar, M. Manook, D. Olaso, J. Yoon, R. Baldi, A. Jackson, S. Knechtle, J. Kwun

    Surgery, Duke Transplant Center, Durham, NC

    *Purpose: Xenotransplantation has been proposed as a bridge to transplant for allosensitized patients. However, the potential of xenotransplantation to broaden HLA allosensitization due to MHC…
  • 2022 American Transplant Congress

    Pre-Transplantation Liver Immunoadsorption Reduces Liver-Specific Antibody and Complement Deposition without Prolonging Survival in Porcine to Baboon Liver Xenotransplantation

    D. J. Cloonan1, T. Coe1, N. Serifis1, R. Matheson1, S. Maggipinto1, D. Firl1, R. Anand2, J. Layer2, L. Queiroz2, K. Stiede2, K. Hall2, M. Youd2, W. Qin2, M. Curtis2, S. Kimura1, I. Rosales1, J. Markmann1

    1Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2eGenesis, Inc, Cambridge, MA

    *Purpose: Triple knock-out pigs lacking GGTA1, β4GALNT2, CMAH genes are hypothesized to be the optimal donor for human xenotransplantation, however there is evidence that TKO…
  • 2022 American Transplant Congress

    Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys

    T. Hirose1, G. Lassiter1, D. Ma1, A. D'Attilio1, I. Rosales1, D. Cloonan1, R. Matheson1, R. Colvin1, W. Qin2, Y. Kan2, J. Layer2, R. Anand2, V. Paragas2, L. Queroz2, X. Tan2, I. Kohnle2, K. Stiede2, K. Hall2, M. Youd2, M. Curtis2, J. Markmann1, T. Kawai1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2eGenesis Inc, Cambridge, MA

    *Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…
  • 2022 American Transplant Congress

    Prolonged Xeno-Kidney Graft Survival in Highly Allo-Sensitized Nonhuman Primate Using Triple-Knockout Donor Pigs with 7 Human Transgenes

    M. Manook1, D. Olaso1, I. Anwar1, J. Yoon1, M. Song1, A. B. Farris2, K. Stiede3, K. Hall3, M. Youd3, S. Knechtle1, J. Kwun1

    1Surgery, Duke Transplant Center, Durham, NC, 2Pathology, Emory University, Atlanta, GA, 3eGenesis Inc, Cambridge, MA

    *Purpose: We have previously shown using porcine kidneys from genetically modified knockout alpha 1,3-galactosyltransferase (GGTA1KO) and human decay accelerating factor transgenic (CD55Tg) pigs that compared…
  • 2022 American Transplant Congress

    First Report of Xenotransplantation from a Pig to Human Recipient

    J. Stern1, V. Tatapudi1, B. Lonze1, Z. Stewart1, M. Mangiola1, M. Wu1, S. Mehta1, E. Weldon1, R. Dieter1, N. Lawson1, A. Griesemer2, B. Parent1, G. Piper1, P. Sommer1, S. Cawthon1, B. Sullivan1, N. Ali1, R. A. Montgomery1

    1NYU Langone Transplant Institute, New York, NY, 2CUMC, New York, NY

    *Purpose: Xenotransplantation of genetically edited pig organs into human recipients can solve the global scarcity of organs for transplantation. Humans lack the α1,3-Gal glycan ubiquitously…
  • 2022 American Transplant Congress

    Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient

    M. Mangiola, V. Tatapudi, J. Stern, Z. Stewart Lewis, B. Lonze, N. Ali, R. Montgomery

    Transplant Institute, NYU Langone Transplant Institute, New York, NY

    *Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…
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