ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2015 American Transplant Congress

    Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury

    K. Nakamura,1 M. Zhang,2 B. Ke,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.

    Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
  • 2015 American Transplant Congress

    Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia

    D. Aufhauser, Jr.,1 Z. Wang,1 S. Cheraghlou,1 T. Bhatti,2 W. Hancock,2,3 M. Levine.1,4

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA; 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 4Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.

    Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
  • 2015 American Transplant Congress

    Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury

    H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.

    Department of Surgery, University of Pittsburgh, Pittsburgh, PA.

    Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…
  • 2015 American Transplant Congress

    Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways

    K. Nakamura,1 M. Zhang,2 B. Ke,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.

    Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, is essential for resistance against liver ischemia-reperfusion injury (IRI). We asked whether SIRT1 may affect cytoprotective…
  • 2015 American Transplant Congress

    The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation

    R. Johns,1,2 M. Laftsidis,2 E. Burrows,2 F. Edwards,2 E. Ablorsu,2 P. James,1 A. Phillips,1,2 A. Asderakis.2

    1University of Cardiff, Cardiff, United Kingdom; 2University Hospital of Wales, Cardiff, United Kingdom.

    IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
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