Articles tagged "Warm ischemia"

2015 American Transplant Congress
Activated Protein C Treatment Protects Steatotic and Non-Steatotic Livers Under Ischemia–Reperfusion Injury in Different Manner
A. Matsuda, N. Kuriyama, H. Kato, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Activated protein C (APC) is known to have the cytoprotective effect on liver ischemia–reperfusion injury (IRI) in rat models. However, it is unclear that whether…
2015 American Transplant Congress
Hydrogen Sulfide Restores Protective Capacity of University of Wisconsin Solution During Normothermic Preservation
J. Grewal,¹ I. Lobb,¹ M. Whiteman,³ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom.
Organ preservation solution is crucial in mitigating effects of ischemia reperfusion injury (IRI) associated with transplantation. Although University of Wisconsin (UW) solution is ideally suited…
2015 American Transplant Congress
Ischemic Cholangiopathy Following Liver Transplantation from Donation After Circulatory Death Donors: Role of Tissue Plasminogen Activator Flush
C. Kubal,¹ R. Mangus,¹ J. Fridell,¹ M. Wingler,² S. Nagai,¹ B. Ekser,¹ J. Tector.¹
¹Department of Surgery, Indiana University, Indianapolis, IN; ²Indiana Organ Procurement Organization, Indianapolis, IN.
Background: Formation of microthrombi within the peribiliary arterial plexus causing necrosis of biliary epithelium may be responsible for ischemic cholangiopathy (IC) after donation after circulatory…
2015 American Transplant Congress
Prediction of Delayed Graft Function By Means of a Web-Based Calculator in Living Related Kidney Transplant: Mexican Single Center Experience
G. Martinez-Mier,¹ E. Soto-Miranda,¹ M. Mendez Lopez,¹ L. Budar Fernandez,¹ M. Trujillo-Martinez,² A. Uscanga-Montesano,² D. Avila y Falfan.²
¹Organ Transplantation, IMSS UMAE189/HRAEV Nefrologia y Trasplantes de Veracruz, Veracruz, Mexico; ²Research, IMSS UMAE 189, Veracruz, Mexico.
Background: Delayed graft function (DGF) is associated with, poor graft survival. Irish validated a model to predict DGF for deceased donor transplants. The model was…
2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…