ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Viral therapy"

  • 2019 American Transplant Congress

    Comparison of Two Dosing Regimens of Valganciclovir for Cytomegalovirus Prophylaxis in High-Risk Liver Transplant Recipients

    A. L. Bixby, L. Fitzgerald, L. Cotiguala, J. M. Park, D. Kaul, C. Sonnenday, S. Tischer

    Michigan Medicine, Ann Arbor, MI

    *Purpose: Significant controversy surrounds the optimal dose and duration of valganciclovir (VGCV) to prevent CMV in high-risk (D+/R-) liver transplant (LT) recipients. High doses cause…
  • 2019 American Transplant Congress

    De-Novo Letermovir Resistant Mutations in Cytomegalovirus-Infected Tissues of Solid Organs Transplant Recipients

    S. HAN, H. Cho, S. Min, Y. Hong

    Internal Medicine, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Letermovir, cytomegalovirus (CMV) DNA-terminase complex (UL51, UL56, and UL89) inhibitor, revealed the efficient prophylactic effect against CMV infection including disease and DNAemia with low-grade…
  • 2019 American Transplant Congress

    Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients

    J. L. Orejas1, F. M. Marty1, A. M. McDonnell2, M. P. Cheng1, E. Arbona-Haddad1, S. P. Hammond1, S. Koo1

    1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, 2Department of Pharmacy, Brigham and Women's Hospital, Boston, MA

    *Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
  • 2019 American Transplant Congress

    Low-Dose Valacyclovir Prophylaxis for Cytomegalovirus Infection in Renal Transplant Recipients with Intermediate Risk

    A. Velioglu1, H. Arikan1, E. Asicioglu1, S. Alagoz2, N. Seyahi2, S. Tuglular1, C. Ozener1

    1Nephrology, Marmara University School of Medicine, İstanbul, Turkey, 2Nephrology, Istanbul University, Cerrahpasa Medical School, İstanbul, Turkey

    *Purpose: According to recent guidelines ganciclovir or valganciclovir chemoprophylaxis is recommended for all kidney transplantation (KT) recipients (except for D-/R- serology) for preventing cytomegalovirus (CMV)…
  • 2019 American Transplant Congress

    The Natural History and Time to Seroconversion of CMV in the Era of Post-Transplantation Chemoprophylaxis: A Single Center Study

    S. Farran, T. Zangeneh, M. Al-Obaidi

    Division of Infectious Diseases, University of Arizona, Tucson, AZ

    *Purpose: The current cytomegalovirus (CMV) guidelines in solid organ transplantation recommend chemoprophylaxis (ppx) in post-kidney transplantation recipients. This approach has led to a reduction in…
  • 2019 American Transplant Congress

    Cidofovir for BK Nephropathy Rescue Treatment: A Single Center Experience

    J. Slatinska1, E. Honsova2, T. Rohal1, A. Slavcev3, P. Hruba4, O. Viklicky1

    1Nephrology, IKEM, Prague, Czech Republic, 2Pathology, IKEM, Prague, Czech Republic, 3Immunology, IKEM, Prague, Czech Republic, 4Transplant Laboratory, IKEM, Prague, Czech Republic

    *Purpose: Cidofovir is a potentially nephrotoxic antiviral drug used primarily as a treatment for CMV retinitis however due to its potent antiviral effects has been…
  • 2019 American Transplant Congress

    Protocol Cidofovir for Refractory Polyomavirus Associated Nephropathy in Kidney Transplant Recipients

    J. Clark, A. Haririan

    University of Maryland Medical Center, Baltimore, MD

    *Purpose: Dose-limiting nephrotoxicity has historically precluded the use of cidofovir for polyomavirus associated nephropathy (PVAN). With incidence of BK viremia in kidney transplant recipients increasing…
  • 2019 American Transplant Congress

    Oral Ribavirin Therapy for Respiratory Syncytial Virus (RSV) in Lung Transplant Recipients: The Impact of Policy Implementation on Cost and Appropriate Use

    B. Berak, N. Sulejmani, A. Jantz, T. Larson, S. Davis, B. Summers

    Henry Ford Hospital, Detroit, MI

    *Purpose: RSV is a leading cause of viral infections in lung transplant recipients and is associated with significant morbidity and mortality. While the role of…
  • 2019 American Transplant Congress

    REHANNA: Renal Transplants in Hepatitis C Negative Recipients with Nucleic Acid Positive Donors with Short Course Direct Acting Antiviral Prophylaxis

    C. Durand, B. Barnaba, D. Brown, N. Bair, F. Naqvi, M. Bowring, D. Segev, M. Sulkowski, N. Desai

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: To mitigate the current organ shortage and underutilization of hepatitis C-infected deceased donor (HCV D+) organs, we evaluated the use of HCV D+ kidneys…
  • 2019 American Transplant Congress

    Long-Term Efficacy of Direct-Acting Antiviral Agents

    J. Zhang, W. Sun, J. Lin, Y. Tian, L. Ma, L. Zhang, Y. Zhu

    Beijing Friendship Hospital, Capital Medical University, Beijing, China

    *Purpose: Long-term efficacy of direct-acting antiviral agents (DAAs) therapy in kidney transplant recipients was unknown. Thus, we aimed to evaluate it in a Chinese cohort…
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