ATC Abstracts

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Articles tagged "Viral therapy"

  • 2020 American Transplant Congress

    Pharmacy Led Initiatives for Treatment of Transplant Recipients of Hepatitis C Viremic Donors in a High Volume Transplant Center

    H. Berry, J. Byrns, L. Crona, T. Capes, J. M. Steinbrink, E. K. Maziarz, C. R. Wolfe

    Duke University Medical Center, Durham, NC

    *Purpose: We describe a multidisciplinary workflow for initiation of hepatitis C virus (HCV) direct-acting antiviral (DAA) therapies post-transplant in the outpatient setting of a high…
  • 2020 American Transplant Congress

    Use of Direct Acting Antiviral Medications in Transplant Recipients Receiving Organs from Hepatitis C Viremic Donors

    S. Bova1, A. Cameron1, C. Durand1, J. Katzianer2, M. LeGrand2, L. Boyer1, J. Glorioso3, L. P. Toman1

    1The Johns Hopkins Hospital, Baltimore, MD, 2Johns Hopkins Home Care Group, Baltimore, MD, 3Thomas Jefferson Univeristy Hospital, Philadelphia, PA

    *Purpose: The availability and high efficacy of direct acting antivirals (DAAs) to treat hepatitis C (HCV) is changing practice in solid organ transplant. A large…
  • 2020 American Transplant Congress

    Use of Letermovir for Cytomegalovirus Management in Thoracic Organ Transplantation

    J. L. Saullo, A. Ferrari, E. M. Eichenberger, J. M. Steinbrink, A. W. Baker, M. Bacchus, E. K. Maziarz, S. Kakoullis, L. Zaffiri, H. Berry, J. M. Reynolds, C. R. Wolfe

    Duke University Medical Center, Durham, NC

    *Purpose: Cytomegalovirus (CMV) commonly affects thoracic solid organ transplant (SOT) recipients, and standard antiviral therapies are limited by myelosuppression, renal dysfunction, and emergence of resistance.…
  • 2020 American Transplant Congress

    Experience with a BKV-Specific, Neutralizing Monoclonal Antibody (MAU868) for Treatment of Severe BK Virus Nephropathy (BKVN) after Kidney Transplant (FDA EIND #139112)

    S. C. Jordan1, S. J. Kovacs2, J. R. Abend3, N. Ammerman1, M. Toyoda1, C. C. Nast1, E. Huang1, R. Najjar1, S. Sethi1, A. Peng1, K. Lim1, M. R. Hodges4, A. Vo1

    1Cedars Sinai Medical Ctr, Los Angeles, CA, 2Novartis Institutes for BioMedical Research, East Hanover, NJ, 3Novartis Institutes for BioMedical Research, Emeryville, CA, 4Amplyx Pharmaceuticals, San Diego, CA

    *Purpose: BK viral reactivation leading to nephropathy and allograft loss in kidney transplant recipients remains a significant challenge. No effective BKV-therapies are currently available. Management…
  • 2020 American Transplant Congress

    Letermovir Treatment for Established Cytomegalovirus Infection in Transplant Recipients

    K. Linder1, C. Kovacs2, K. Mullane3, C. Wolfe4, N. Clark5, C. Butkus Small6, R. La Hoz7, J. Smith8, C. Kotton9, A. Limaye10, M. Malinis11, M. Hakki12, A. Mishkin13, A. Gonzalez14, D. Kaul1

    1U Michigan, Ann Arbor, MI, 2Cleveland Clinic, Cleveland, OH, 3U Chicago, Chicago, IL, 4Duke, Durham, NC, 5Loyola, Chicago, IL, 6Cornell, NYC, NY, 7UTSW, Dallas, TX, 8U Wisconsin, Madison, WI, 9Mass General, Boston, MA, 10U Washington, Seattle, WA, 11Yale, New Haven, CT, 12OHSU, Portland, OR, 13Temple, Philadelphia, PA, 14West Coast ID, Safety Harbor, FL

    *Purpose: The purpose of the study was to describe the patterns of use and clinical/virologic outcomes of letermovir treatment for established CMV infection in transplant…
  • 2020 American Transplant Congress

    The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses

    E. David1, M. Zhu2, W. Parker2, N. MacIver1, A. D. Kirk2, E. T. Chambers1

    1Pediatrics, Duke University, Durham, NC, 2Surgery, Duke University, Durham, NC

    *Purpose: Cytomegalovirus (CMV) infection remains a significant issue in transplantation, especially in those who are undernourished. While undernutrition is associated with impaired T cell immunity…
  • 2019 American Transplant Congress

    Early Achievement of Sustained Virological Response in Liver Transplant Recipients with Hepatitis C Reduces Risks of End Stage Renal Disease

    M. Yoshikawa1, T. Fukumoto2

    1Nephrology, Kobe University Hospital, Kobe, Japan, 2Hepato-Biliary-Pancreas Surgery, Kobe University Hospital, Kobe, Japan

    *Purpose: Chronic kidney disease (CKD) is common after liver transplantation (LT) and result worse morbidity and mortality. Hepatitis C virus (HCV) infection is recognized as…
  • 2019 American Transplant Congress

    Comparison of Two Dosing Regimens of Valganciclovir for Cytomegalovirus Prophylaxis in High-Risk Liver Transplant Recipients

    A. L. Bixby, L. Fitzgerald, L. Cotiguala, J. M. Park, D. Kaul, C. Sonnenday, S. Tischer

    Michigan Medicine, Ann Arbor, MI

    *Purpose: Significant controversy surrounds the optimal dose and duration of valganciclovir (VGCV) to prevent CMV in high-risk (D+/R-) liver transplant (LT) recipients. High doses cause…
  • 2019 American Transplant Congress

    De-Novo Letermovir Resistant Mutations in Cytomegalovirus-Infected Tissues of Solid Organs Transplant Recipients

    S. HAN, H. Cho, S. Min, Y. Hong

    Internal Medicine, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Letermovir, cytomegalovirus (CMV) DNA-terminase complex (UL51, UL56, and UL89) inhibitor, revealed the efficient prophylactic effect against CMV infection including disease and DNAemia with low-grade…
  • 2019 American Transplant Congress

    Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients

    J. L. Orejas1, F. M. Marty1, A. M. McDonnell2, M. P. Cheng1, E. Arbona-Haddad1, S. P. Hammond1, S. Koo1

    1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, 2Department of Pharmacy, Brigham and Women's Hospital, Boston, MA

    *Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
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