ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Viral therapy"

  • 2020 American Transplant Congress

    Comparison of Prophylaxis Strategies for CMV Infection in Liver Transplant Recipients

    K. Schnelle, A. Leino, M. Chunduru, L. Von Stein, O. Witkowsky

    The Ohio State Wexner Medical Center, Columbus, OH

    *Purpose: The best strategy to prevent cytomegalovirus (CMV) following liver transplantation is not defined for intermediate risk recipients (recipient seropositive (R+) regardless of donor status).…
  • 2020 American Transplant Congress

    Brincidofovir for Adenovirus Disease in Adult Renal Transplant Recipients: A Case Series

    F. Zervou1, I. Zacharioudakis1, S. A. Mehta2, H. J. Neumann2

    1Infectious Diseases, New York University Langone, New York, NY, 2New York University Langone Transplant Institute, New York, NY

    *Purpose: Adenovirus infection can lead to disease in solid organ transplant recipients, including disease of the allograft. Treatment options for severe disease are limited. Brincidofovir…
  • 2020 American Transplant Congress

    Utilization of Organs from Donors Exposed to Hepatitis C: ? Standard of Care

    M. Marvin1, S. Gaines2, P. Mohan3, A. Kotru1, C. Koo1, B. Addissie4, A. Unzueta4, S. Khurana4

    1Transplantation and Liver Surgery, Geisinger, Danville, PA, 2Pharmacy, Geisinger, Danville, PA, 3Nephrology, Geisinger, Danville, PA, 4Hepatology, Geisinger, Danville, PA

    *Purpose: To report the results of a clinical program to utilize livers and kidneys from donors exposed to Hepatitis C.*Methods: We initially started to explore…
  • 2020 American Transplant Congress

    Viral Kinetics of De Novo HCV Infection and Response to Antiviral Therapy in Liver and Kidney Transplant Recipients Receiving HCV-Viremic Donors

    N. Terrault1, J. Burton2, E. Verna3, C. Mobley4, D. Victor4, J. Trotter5, C. Niemann6, R. Rubin7

    1University of Southern California, Los Angeles, CA, 2UC, Denver, CO, 3Columbia Universeity, New York, NY, 4Houston Methodist, Houston, TX, 5Baylor University, Dallas, TX, 6UCSF, San Francisco, CA, 7Piedmont Atlanta Hosptial, Atlanta, GA

    *Purpose: There is general agreement that expanded use of organs from HCV-viremic donors is desirable, including in recipients without HCV infection. However, the optimal treatment…
  • 2020 American Transplant Congress

    Efficacy of Generic Sofosbuvir and Branded Daclatasvir Compared to Sofosbuvir and Ledipasvir Combination in the Treatment of Genotype 4 Hepatitis C Virus

    H. Joharji, D. Alkortas, A. Ajlan, E. Devol, M. Ahmed, F. Aba Al-Khail, H. Elsiesy, M. Alsebayel, H. Alashgar, M. Alquaiz, W. Alhamoudi, A. Almoshishir, A. Aljedai

    King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

    *Purpose: Genotype 4 HCV is the most common genotype in Saudi Arabia and the Middle East. Management of HCV has shifted in the last few…
  • 2020 American Transplant Congress

    Glecaprevir-Pibrentasvir Effect on Tacrolimus Troughs in Abdominal Transplant Recipients

    M. Chunduru, K. Schnelle, H. Winters, O. Witkowsky, L. Von Stein

    The Ohio State Wexner Medical Center, Columbus, OH

    *Purpose: Glecaprevir-pibrentasvir (GP) is one of several pangenotypic therapies available for the treatment of hepatitis C. Historical use of ritonavir based hepatitis C therapies increased…
  • 2020 American Transplant Congress

    Association between Ezetimibe Usage and Hepatitis C RNA Levels in Uninfected Kidney Transplant Recipients Who Received Hepatitis C Infected Kidneys

    A. Azhar, M. Yazawa, M. Talwar, V. Balaraman, A. Bhalla, U. A. Agbim, B. Maliakkal, J. P. Kothadia, S. Nair, J. D. Eason, M. Z. Molnar

    James D. Eason Transplant Institute, Methodist University Hospital, Memphis, TN

    *Purpose: Our previous data showed that transplantation of kidneys from hepatitis C virus (HCV) infected donors to HCV negative recipients achieved excellent short-term graft function,…
  • 2020 American Transplant Congress

    Single Center Experience of Valganciclovir and Adjunctive CMV IVIG for the Treatment of CMV Infection in Lung Transplant Recipients

    A. A. Fernandez1, N. Sinha2, M. Loebe2, J. Glaze2, S. Manickavel2, M. Fernandez2, T. Pastrana2, J. Simkins3, J. Camargo3, M. I. Morris3, L. Abbo3, Y. Natori3

    1Infectious Disease, University of Miami Jackson Memorial Hospital, Miami, FL, 2University of Miami Jackson Memorial Hospital, Miami, FL, 3Transplant Infectious Disease, University of Miami Jackson Memorial Hospital, Miami, FL

    *Purpose: Cytomegalovirus(CMV) infection happens commonly and causes significant morbidity in lung transplant (LTx) recipients. The use of CMV hyperimmune globulin (CMVIg) as an adjunctive treatment…
  • 2020 American Transplant Congress

    Longer-Term Outcomes from the THINKER and EXPANDER Trials of Transplantation Using HCV-Viremic Kidneys

    V. S. Potluri1, F. Naqvi2, P. Reese1, M. Shah1, D. Brown2, S. Prenner1, A. Loupy3, A. Woodards1, P. Abt1, E. Blumberg1, J. Trofe-Clark1, D. Segev2, R. Bloom1, D. Sawinski1, C. Durand2, P. Porrett1, M. Levine1, D. Goldberg4, N. Desai2

    1University of Pennsylvania, Philadelphia, PA, 2Johns Hopkins, Baltimore, MD, 3Paris Transplant Group, Paris, France, 4University of Miami, Miami, FL

    *Purpose: The practice of transplanting HCV-viremic kidneys into HCV-negative recipients has become more common, but longer-term outcomes have not been reported. We present data on…
  • 2020 American Transplant Congress

    Access to Direct Acting Antiviral Therapy for Recipients of Solid Organs from Hepatitis C Viremic Donors

    C. Edmonds, A. Carver, J. DeClercq, L. Choi, M. Peter, R. Forbes, B. Concepcion, K. Schlendorf, R. Perri

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Emerging data supports transplantation of organs from hepatitis C-positive (HCV) donors to expand the donor pool, but access to direct acting antivirals (DAAs) to…
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