ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Viral therapy"

  • 2020 American Transplant Congress

    Use of Letermovir for Cytomegalovirus Management in Thoracic Organ Transplantation

    J. L. Saullo, A. Ferrari, E. M. Eichenberger, J. M. Steinbrink, A. W. Baker, M. Bacchus, E. K. Maziarz, S. Kakoullis, L. Zaffiri, H. Berry, J. M. Reynolds, C. R. Wolfe

    Duke University Medical Center, Durham, NC

    *Purpose: Cytomegalovirus (CMV) commonly affects thoracic solid organ transplant (SOT) recipients, and standard antiviral therapies are limited by myelosuppression, renal dysfunction, and emergence of resistance.…
  • 2020 American Transplant Congress

    Experience with a BKV-Specific, Neutralizing Monoclonal Antibody (MAU868) for Treatment of Severe BK Virus Nephropathy (BKVN) after Kidney Transplant (FDA EIND #139112)

    S. C. Jordan1, S. J. Kovacs2, J. R. Abend3, N. Ammerman1, M. Toyoda1, C. C. Nast1, E. Huang1, R. Najjar1, S. Sethi1, A. Peng1, K. Lim1, M. R. Hodges4, A. Vo1

    1Cedars Sinai Medical Ctr, Los Angeles, CA, 2Novartis Institutes for BioMedical Research, East Hanover, NJ, 3Novartis Institutes for BioMedical Research, Emeryville, CA, 4Amplyx Pharmaceuticals, San Diego, CA

    *Purpose: BK viral reactivation leading to nephropathy and allograft loss in kidney transplant recipients remains a significant challenge. No effective BKV-therapies are currently available. Management…
  • 2020 American Transplant Congress

    Letermovir Treatment for Established Cytomegalovirus Infection in Transplant Recipients

    K. Linder1, C. Kovacs2, K. Mullane3, C. Wolfe4, N. Clark5, C. Butkus Small6, R. La Hoz7, J. Smith8, C. Kotton9, A. Limaye10, M. Malinis11, M. Hakki12, A. Mishkin13, A. Gonzalez14, D. Kaul1

    1U Michigan, Ann Arbor, MI, 2Cleveland Clinic, Cleveland, OH, 3U Chicago, Chicago, IL, 4Duke, Durham, NC, 5Loyola, Chicago, IL, 6Cornell, NYC, NY, 7UTSW, Dallas, TX, 8U Wisconsin, Madison, WI, 9Mass General, Boston, MA, 10U Washington, Seattle, WA, 11Yale, New Haven, CT, 12OHSU, Portland, OR, 13Temple, Philadelphia, PA, 14West Coast ID, Safety Harbor, FL

    *Purpose: The purpose of the study was to describe the patterns of use and clinical/virologic outcomes of letermovir treatment for established CMV infection in transplant…
  • 2020 American Transplant Congress

    The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses

    E. David1, M. Zhu2, W. Parker2, N. MacIver1, A. D. Kirk2, E. T. Chambers1

    1Pediatrics, Duke University, Durham, NC, 2Surgery, Duke University, Durham, NC

    *Purpose: Cytomegalovirus (CMV) infection remains a significant issue in transplantation, especially in those who are undernourished. While undernutrition is associated with impaired T cell immunity…
  • 2020 American Transplant Congress

    Clinical and Laboratory Characteristics of Early and Late-Onset Cytomegalovirus Infection Following Universal Prophylaxis in Kidney Transplant Recipients

    M. M. Tavakol, B. Lee, S. Ashimine, H. Crossman, M. Park, Z. Laszik, J. Roberts

    University of California, San Francisco, San Francisco, CA

    *Purpose: Cytomegalovirus (CMV) is the most important viral infection in organ recipients and can cause life-threatening infections, compromising long-term graft function. Most transplant centers use…
  • 2020 American Transplant Congress

    An OPO’s Experience in Increasing Transplantation with the Hope Project

    R. P. Wood, M. Ferguson, K. Myer, R. Cruz, P. Gillentine

    CMO, LifeGift, Houston, TX

    *Purpose: The purpose of this report is to describe one OPO’s experience in participating in the Hope Project. This research project is designed to evaluate…
  • 2020 American Transplant Congress

    Preemptive Direct Acting Antiviral Therapy as Prophylaxis in Donor HCV-Positive to Recipient HCV-Negative Solid Organ Transplant: a Comprehensive Review

    M. Mavuram, S. Mavuram, H. Samant, S. Pandit, B. Samant, J. Morris, J. Alexander

    Gastroenterology, Louisiana State University of Health Sciences Shreveport, Shreveport, LA

    *Purpose: With the advent of highly effective and safe oral Direct acting Antiviral agents (DAAs), several transplant centers have adopted protocols for using HCV positive…
  • 2020 American Transplant Congress

    Cytomegalovirus Infection and Outcomes in Pancreas Transplant Recipients in the Prophylaxis Era

    M. Jorgenson1, N. Marka2, G. Leverson2, J. Smith2, J. Odorico2

    1UW Health, Madison, WI, 2UWMF, Madison, WI

    *Purpose: Evaluate epidemiology and outcomes of cytomegalovirus infection (CMV) in pancreas transplant recipients (PTR) in the current era of valganciclovir (VGC) prophylaxis (PPX)*Methods: Adult PTRs…
  • 2020 American Transplant Congress

    Comparison of Prophylaxis Strategies for CMV Infection in Liver Transplant Recipients

    K. Schnelle, A. Leino, M. Chunduru, L. Von Stein, O. Witkowsky

    The Ohio State Wexner Medical Center, Columbus, OH

    *Purpose: The best strategy to prevent cytomegalovirus (CMV) following liver transplantation is not defined for intermediate risk recipients (recipient seropositive (R+) regardless of donor status).…
  • 2020 American Transplant Congress

    Brincidofovir for Adenovirus Disease in Adult Renal Transplant Recipients: A Case Series

    F. Zervou1, I. Zacharioudakis1, S. A. Mehta2, H. J. Neumann2

    1Infectious Diseases, New York University Langone, New York, NY, 2New York University Langone Transplant Institute, New York, NY

    *Purpose: Adenovirus infection can lead to disease in solid organ transplant recipients, including disease of the allograft. Treatment options for severe disease are limited. Brincidofovir…
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