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Articles tagged "Vaccination"

  • 2022 American Transplant Congress

    Comparing The Immunologic Responses Between Kidney Transplant Recipients Receiving Standard Immunosuppression And CNI Reduction After Two Doses Of ChAdOx-1 And A Booster Dose BNT162b2

    S. Phirom1, T. Kitrungphaiboon2, W. Jantarabenjakul2, Y. Avihingsanon2, W. Prasithsirikul3, J. Vanichanan4, P. Hansasuta5, N. Townamchai6

    1Nephrology division, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 2King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 3Bamrasnaradura infectious disease institute, Bangkok, Thailand, 4Infectious diseases, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 5Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 6Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand

    *Purpose: Immunosuppression can impair immunological responses after vaccination in kidney transplant recipients (KTR). However, little is known about the effect of the booster dose of…
  • 2022 American Transplant Congress

    Sars-cov-2 Antibodies Transitions After Vaccination In Solid Organ Transplant Recipients: Multicenter Study In Japan

    K. Unagami1, M. Yoshikawa2, Y. Natori3, K. Omoto1, H. Ishida1, H. Date4, R. Imamura5, T. Ito4, K. Miyaji6, S. Takahara7, K. Yuzawa8, O. Satoko9, Y. Hirota10, H. Egawa1

    1Tokyo Women's Medical University, Tokyo, Japan, 2Kyoto Prefectural University of Medicine, Kyoto, Japan, 3University of Miami, Pinecrest, FL, 4Kyoto University, Kyoto, Japan, 5Dept. of Urology, Osaka Univ. Graduate School of Medicine, Suita, Japan, 6Renal Transplantation, Takatsuki General Hospital, Takatsuki, Japan, 7Kansai Medical Hospital, Toyonaka, Japan, 8Tranplantation Surgery, National Hospital Organization Mito Medical Center, Mito, Japan, 9Public Health, Osaka City University Graduate School of Medicine and Research Center for Infectious, Osaka City University Graduate School of Medicine, Osaka, Japan, 10Clinical Epidemiology Research Center, Miyama, Japan

    *Purpose: For purpose of SARS-CoV-2 infection control, vaccination was started in worldwide, however, low reactivity of antibody production after vaccination is a concern for solid…
  • 2022 American Transplant Congress

    Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients

    J. Mitchell1, T. P. Chiang1, J. Alejo1, A. Chang1, A. Abedon1, R. Avery1, A. Tobian1, A. Massie1, M. Levan1, D. Warren1, J. Garonzik-Wang2, D. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin-Madison, Madison, WI

    *Purpose: Mycophenolate mofetil (MMF) use is associated with decreased antibody response to the SARS-CoV-2 mRNA vaccine series in heart and lung transplant recipients (HLTRs). Higher…
  • 2022 American Transplant Congress

    A Machine Learning Model for Predicting Antibody Response to 2-Dose Sars-cov-2 MRNA Vaccine Series in Transplant Recipients

    J. L. Alejo1, J. Mitchell1, T. Chiang1, A. Abedon1, W. Werbel1, R. Avery1, A. Tobian1, A. Massie1, J. Garonzik-Wang2, D. Segev1, S. Bae1

    1JHU, Baltimore, MD, 2U of Wisconsin, Madison, WI

    *Purpose: Understanding risk factors for impaired vaccine responses can guide strategies for testing, additional dose recommendations, and vaccine schedules to provide improved protection in solid…
  • 2022 American Transplant Congress

    Six-Month Antibody Kinetics and Durability After Three Doses of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients

    A. Abedon1, J. Alejo1, T. Chiang1, J. Mitchell1, J. Kim1, L. Thomas1, R. Avery1, A. Tobian1, A. Massie1, M. Levan1, D. Warren1, J. Garonzik-Wang2, D. Segev1, W. Werbel1

    1Johns Hopkins, Baltimore, MD, 2University of Wisconsin, Madison, WI

    *Purpose: Some solid-organ transplant recipients (SOTRs) with low or negative antibody levels after a 2-dose mRNA vaccine series against SARS-CoV-2 experience boosting after a third…
  • 2022 American Transplant Congress

    Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients

    Y. Natori1, E. Martin2, A. Mattiazzi3, J. Bini Viotti1, K. S. Ortecho4, S. Pallikkuth5, S. Anjan1, J. Simkins1, G. Guerra3

    1Department of Medicine, Division of Infectious Diseases, University of Miami, Miami, FL, 2Department of Medicine, Division of Hepatology, University of Miami, Miami, FL, 3Department of Medicine, Division of Nephrology, University of Miami, Miami, FL, 4Miami Transplant Institute, Jackson Health System, Miami, FL, 5University of Miami, Miami, FL

    *Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…
  • 2022 American Transplant Congress

    The Impact Of Monoclonal Antibody Against Sars-CoV2 And Vaccination On Outcomes In Kidney Transplant Recipients With Covid-19

    N. M. Ali, V. Tatapudi, R. Chand, k. Sureau, S. Mehta, R. Montgomery

    NYU Langone Transplant Institute, New York, NY

    *Purpose: Solid organ transplant recipients are at high risk of morbidity and mortality from coronavirus disease 2019 (COVID-19) with mortality rates as high as 30%…
  • 2022 American Transplant Congress

    Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept

    J. Mitchell1, J. Alejo1, T. P. Chiang1, J. N. Blankson1, A. H. Karaba1, B. Woldemeskel1, C. Garliss1, A. Chang1, A. Abedon1, R. K. Avery1, A. Tobian1, A. B. Massie1, J. Garonzik-Wang2, D. L. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin, Madison, WI

    *Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…
  • 2022 American Transplant Congress

    High Case Fatality Rate Among Fully Vaccinated Kidney Transplant Recipients with Breakthrough Covid-19 During the Delta Surge

    K. Vieira, E. Klein, A. Lerner, D. Farmakioits

    Rhode Island Hospital/Brown University, Providence, RI

    *Purpose: Organ transplant recipients (OTR) have worse outcomes from COVID-19 and weaker antibody responses to vaccination than do immunocompetent individuals. Data on clinical outcomes among…
  • 2022 American Transplant Congress

    Evolution of Cellular and Humoral Immunity During and After a Three Doses-Course of mRNA-1273 COVID-19 Vaccine in Kidney Transplant Recipients

    D. Cucchiari1, N. Egri1, J. Casals-Urquiza2, J. Del Risco-Zevallos1, D. Rodríguez-Espinosa3, E. Montagud-Marrahi2, J. Rovira4, M. Ramirez-Bajo5, E. Banón-Maneus5, P. Ventura-Aguiar2, M. Pascal1, I. Revuelta6, B. Bayès2, F. Diekmann2

    1Hospital Clínic de Barcelona, Barcelona, Spain, 2Hospital Clinic de Barcelona, Barcelona, Spain, 3Nephrology and Renal Transplantation, Hospital Clinic of Barcelona, Barcelona, Spain, 4Laboratori Experimental de Nefrologia i Trasplantament (LENIT), IDIBAPS, Barcelona, Spain, 5IDIBAPS, Barcelona, Spain, 6Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain

    *Purpose: Seroconversion after a 2 doses of mRNA COVID-19 vaccine in kidney transplant recipients (KTR) ranges between 30 and 50% in different series. We previously…
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