Articles tagged "Vaccination"

2022 American Transplant Congress
Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, B. Lonze¹, E. Weldon¹, Z. Stewart¹, C. DiMaggio¹, J. Allen³, S. Gray-Gaillard³, S. Solis³, M. Tuen³, J. Leonard¹, R. Montgomery¹, R. Herati³
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY, ³NYU Langone Health, New York, NY
*Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
2022 American Transplant Congress
Immunity Rates to Hepatitis B Among Solid Organ Transplant Recipients
S. Kopf¹, J. Walker², K. Bruxvoort³, H. Budhwani³, A. Nellore⁴
¹Infectious Disease, University of Alabama at Birmingham Hospital, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham Hospital, Birmingham, AL, ⁴University of Alabama, Birmingham, AL
*Purpose: Immunosuppression after transplantation decreases vaccine responsiveness. Thus, to be best protected from post-transplant communicable diseases, vaccination of organ transplant candidates in the pre-transplant period…
2022 American Transplant Congress
Adverse Renal Events After BNT162b2 Pfizer/BioNTech COVID-19 Vaccine in Kidney Transplant Recipients
H. K. Sran¹, E. Wong¹, M. R. D'Costa², A. Lim², Q. Lim², A. Vathsala¹
¹National University of Singapore, Singapore, Singapore, ²National University Centre for Organ Transplantation, National University Hospital, Singapore, Singapore
*Purpose: Adverse events of a novel mRNA vaccine are not well described in Kidney Transplant Recipients(KTR), especially the risk of immune activation or recurrent glomerulonephritis(GN),…
2022 American Transplant Congress
A Randomized, Controlled, Double-blind Trial Of Inulin To Boost Response To A Third Covid-19 Vaccine Dose In Kidney Transplant Recipients.
J. Singer¹, M. Tunbridge², T. Salehi³, G. Perkins⁴, B. Grubnor-Bauk⁵, B. Sim³, T. Ying⁶, P. T. Coates³, S. J. Chadban¹
¹Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia, ²Renal Medicine, Royal Adelaide Hospital, Adelaide, Australia, ³Royal Adelaide Hospital, Adelaide, Australia, ⁴School of Biological Sciences, University of Adelaide, Adelaide, Australia, ⁵Adelaide University, Adelaide, Australia, ⁶Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTR) commonly exhibit inadequate responses to 2-dose COVID-19 vaccination schedules and remain at increased risk of severe COVID-19. Gut dysbiosis is…
2022 American Transplant Congress
Effect of Covid-19 Vaccination on Markers of Rejection in Heart Transplant Recipients
Z. Pieters¹, E. Bruno¹, S. Kim¹, S. De Sirkar¹, M. Thomas¹, S. B. Sharmin², M. Liebo¹, A. Heroux¹, N. Clark¹, G. Reid¹, S. Uprichard², M. Yu¹
¹Medicine, Loyola University Medical Center, Maywood, IL, ²Loyola University Chicago, Chicago, IL
*Purpose: Heart transplant recipients have worse survival with COVID-19 than the general population, highlighting the importance of vaccination in these patients. The impact of vaccination…
2022 American Transplant Congress
An Analysis of Serological Response and Infection Outcomes Following Oxford Astra-Zeneca (azd1222) and Pfizer-Biontech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Pancreas Transplant Patients
A. Asderakis¹, U. Khalid¹, G. Koimtzis¹, M. Ponsford², L. Szabó¹, L. Grant², S. Jolles², I. Humphreys³
¹Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, ²Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom, ³Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
*Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. This study aims to compare the humoral responses between the Oxford-Astra-Zeneca(AZ) and BNT162b2(Pfizer-BioNTech) vaccines in…
2022 American Transplant Congress
Assessment of Humoral and Cellular Immune Responses to Sars Cov-2 Vaccination in Immunocompromised Renal Allograft Recipients
B. Shin, R. Zhang, T. M. Gadsden, A. Petrosyan, A. Vo, N. Ammerman, S. Sethi, E. Huang, A. Peng, R. Najjar, J. Atienza, I. Kim, S. C. Jordan
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: SARS CoV-2 vaccination elicits both robust humoral and T-cell immune responses in healthy individuals. However, a comprehensive assessment of immune responses to SARS-CoV-2 vaccination…
2022 American Transplant Congress
Mandatory Vaccine Requirements in Waitlisted Transplant Patients: A Transplant Center’s Perspective – A Call to Action
M. Debroy¹, K. Andreoni¹, A. Beach², K. Chavin¹
¹University Hospitals Cleveland Medical Center/Case Western Reserve, Cleveland, OH, ²University Hospitals, Cleveland, OH
*Purpose: The global pandemic caused by the SARS Cov-2 virus has caused unprecedented, previously unthinkable changes. COVID-19 infection in transplanted patients carries an ~ 30%…
2022 American Transplant Congress
A Prospective Randomised, Controlled Trial Switching Sirolimus For Mycophenolate To Enhance Immunological Responses To Third Dose Covid-19 Vaccination In Kidney Transplant Recipients With Poor Baseline Humoral Immunity
M. J. Tunbridge¹, G. Perkins², T. Salehi¹, B. Grubor-Bauk³, B. Sim¹, T. Ying⁴, J. J. Singer⁵, S. C. Barry⁶, P. Hissaria⁷, S. Chadban⁸, P. T. Coates¹
¹Central and Northern Adelaide Renal and Transplant Services, Royal Adelaide Hospital, Adelaide, Australia, ²School of Biological Sciences, University of Adelaide, Adelaide, Australia, ³Basil Hetzel Institute, University of Adelaide, Adelaide, Australia, ⁴University of Sydney, Lilyfield, Ne, Australia, ⁵Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, The University of Sydney, Australia, ⁶School of Medical Sciences, University of Adelaide, Adelaide, Australia, ⁷Department of Immunology, Royal Adelaide Hospital, Adelaide, Australia, ⁸Department of Nephrology, Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTR) have inadequate responses to 2-dose COVID vaccination schedules and are at increased risk of severe COVID-19. Formation of T cell…
2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
V. H. Ferreira, V. Hall, T. M. Marinelli, M. Ierullo, V. Kulasingam, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…