Articles tagged "Vaccination"

2022 American Transplant Congress
Impact of Sars-CoV-2 Vaccination on Donor-Derived Cell Free DNA Levels in Renal Transplant Recipients
H. Alvarado Verduzco, E. Daniel, D. Kim, A. Hussain, S. Mohan, D. Cohen
Columbia University Irving Medical Center, New York, NY
*Purpose: COVID-19 poses a disproportionate threat to renal transplant recipients (RTR), who are chronically immunosuppressed. Studies have indicated a 16% mortality rate compared to
2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
V. H. Ferreira, V. Hall, T. M. Marinelli, M. Ierullo, V. Kulasingam, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…
2022 American Transplant Congress
Higher Immunogenicity of a Third Heterologous Dose with BNT262b2 Mensanger RNA Vaccine Compared to a Homologous Dose in Kidney Transplant Recipients Fully Vaccinated with Inactivated Whole-Virion CoronaVac Vaccine
L. V. Pouzo¹, M. Nakamura¹, L. A. Viana², E. Lucena¹, M. Jesus¹, G. Bittencourt Pereira Lima¹, J. Medina¹, H. Tedesco¹, M. Cristelli¹
¹Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil, ²Nephrology, Hospital do rim, Sao Paulo, Brazil
*Purpose: This study aims to compare the immunogenicity of a third dose of the heterologous BNT262b2 mRNA vaccine versus the homologous inactivated whole-virion CoronaVac vaccine…
2022 American Transplant Congress
Pathological Changes in Kidney Allografts Associated with COVID-19 Vaccination
S. Shelton, N. Hellenga, P. Burke
Christiana Care Health System - Kidney Transplant Program, Newark, DE
*Purpose: The Coronavirus Disease 2019 (COVID-19) pandemic prompted widespread vaccination for the immunosuppressed population starting in January 2021 with minimal information on safety outcomes. The…
2022 American Transplant Congress
B Cells Fit for Germinal Center Activity Predict Response to a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
E. A. Thompson¹, A. H. Karaba¹, K. Cascino¹, K. Roznik¹, T. Chiang¹, L. Biavatti¹, A. T. Abedon¹, J. L. Alejo¹, S. L. Klein¹, J. N. Blankson¹, D. S. Warren¹, C. X. Qin¹, J. Mitchell¹, J. M. Garonzik-Wang², B. J. Boyarsky¹, D. L. Segev¹, A. A. Tobian¹, W. A. Werbel¹, A. L. Cox¹, J. R. Bailey¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: While SARS-CoV-2 vaccination has dramatically reduced COVID-19 severity in the general population, fully vaccinated solid organ transplant recipients (SOTRs) demonstrate reduced seroconversion and increased…
2022 American Transplant Congress
High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients
C. C. Van Leer Buter¹, R. A. Hoek², E. A. Verschuuren³, R. D. de Vries⁴, D. van Baarle¹, M. van der Heiden¹, H. G. Niesters¹, C. GeurtsvanKessel⁴
¹Dept. of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ³Dept. of Pulmonary Diseases,, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
2022 American Transplant Congress
Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration
N. M. Ali¹, S. Mehta¹, V. Tatapudi¹, A. Mattoo¹, I. Soomro¹, J. Benstein¹, H. Neumann¹, F. Zervou¹, J. Miles², R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, CA
*Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
2022 American Transplant Congress
Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients
Y. Yoo¹, J. Husson², T. Iraguha³, S. Niederhaus⁴, X. Wen⁵, A. Crane⁵, A. Carrier⁵, J. Avruch⁵, A. Ahuja⁶, M. Mathew⁷, S. Dahiya⁸, A. P. Rapoport⁸, D. Atanackovic⁸, K. K. Saharia²
¹Inst of Human Virology, Baltimore, MD, ²Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, ³Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, ⁴Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, ⁵Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, ⁶Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, ⁷Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, ⁸Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD
*Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
2022 American Transplant Congress
Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination
J. L. Alejo¹, T. Chiang¹, J. Mitchell¹, A. Abedon¹, L. Thomas¹, A. Chang¹, S. Bae¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…
2022 American Transplant Congress
Factors Contributing To SARS-CoV-2 Vaccine Hesitancy In Kidney Transplant Candidates
P. LaBella¹, E. Silverman², S. Mehta³, N. M. Ali⁴
¹Transplant Infectious Disease, New York University Langone Health, New York, NY, ²Transplant Infectious Disease, New York University Grossman School of Medicine, New York, NY, ³New York University Langone Transplant Institute, New York, NY, ⁴Transplant Institute, NYU Langone Health, New York, NY
*Purpose: SARS-CoV-2 infection in kidney transplant recipients is associated with an increased risk of severe disease and mortality relative to other patient populations, with mortality…