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Articles tagged "Vaccination"

  • 2022 American Transplant Congress

    Transplant Patients Risk for SARS-CoV-2 Infection Post-2nd Vaccine Dose; We Are Not Home and Dry Yet

    G. Koimtzis1, L. Szabó1, P. Nagaraja1, C. Chalklin1, D. Elker2, A. Asderakis1

    1Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, 2Cardiff Transplant Unit, University Hosptal of Wales, Cardiff, United Kingdom

    *Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. Data of transplant patients’ infections post-2nd vaccine dose is not available. The aim of the…
  • 2022 American Transplant Congress

    COVID-19 Vaccination Induces a Poor Interleukin-21 Memory T-cell Response in Kidney Transplant Recipients

    S. R. Malahe1, Y. den Hartog1, R. de Kuiper1, D. Reijerkerk1, D. Geers2, C. H. GeurtsvanKessel2, M. M. Kho1, R. D. de Vries2, M. E. Reinders1, C. C. Baan1

    1Internal Medicine, Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands, 2Viroscience, Erasmus MC, Rotterdam, Netherlands

    *Purpose: COVID-19-related morbidity and mortality is high among kidney patients. Several studies recently suggested low humoral and cellular immune responses after two doses of mRNA-1273…
  • 2022 American Transplant Congress

    Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients

    A. E. Woolley, N. Sharma, G. Zhou, A. Kim, E. Ryan, M. Joyce, H. Goldberg, M. Givertz, M. Mehra, E. Woodcome, V. Durney, S. Marshall, K. Townsend, A. Coppolino, S. Tullius, S. Malek, H. Mallidi, L. Baden, A. Chandraker

    Brigham & Women's Hospital, Boston, MA

    *Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…
  • 2022 American Transplant Congress

    Clinical Characteristics Of Serologic Non-responders To Covid-19 Booster Vaccination In A Cohort Of Solid Organ Transplant Recipients.

    F. N. Zervou1, K. Khalil1, T. Lao1, D. Wood2, S. Jonche1, A. Mattoo1

    1Transplant Institute, NYU Langone Health, New York, NY, 2New York University Langone Health, Brooklyn, NY

    *Purpose: The purpose of this study was to assess the clinical characteristics of serologic non-responders to COVID-19 booster vaccination in a cohort of solid organ…
  • 2022 American Transplant Congress

    Impaired Cellular Immunity and Elevated Myeloid Derived Suppressor Cells in Kidney Transplant Recipients with Impaired Antibody Response to Covid-19 Vaccination

    B. Nibhanupudy1, K. Mcdonald1, M. Angelis1, L. T. Chin1, P. Wai1, R. Metzger1, C. Ashokkumar2, R. Sindhi2

    1AdventHealth Transplant Institute, Orlando, FL, 2Plexision, Inc, Pittsburgh, PA

    *Purpose: To evaluate post-vaccination cellular and antibody (Ab) immunity after COVID-19 vaccination in single blood samples from 17 kidney transplant (KT) recipients who had received…
  • 2022 American Transplant Congress

    T and B Cell Response to 3 Dose Covid Vaccine Series for Kidney Transplant Patients on Belatacept

    J. Christensen1, I. Yakubu2, D. Kumar1, D. Cornett3, M. A. Miller3, M. Altrich3, L. Flebbe-Rehwaldt3, R. Thompson1, G. Gupta1

    1Internal Medicine, Transplant Nephrology, VCUHealth, Richmond, VA, 2Pharmacy, VCUHealth, Richmond, VA, 3Eurofins Viracor, Lee's Summit, MO

    *Purpose: Data shows COVID vaccine response after 2 doses in patients on Belatacept immunosuppression (IS) is low, with reported rates of seroconversion (as measured by…
  • 2022 American Transplant Congress

    Real-Life Prevention of Breakthrough SARS-CoV-2 Infections by mRNA Vaccines in Kidney Transplant Recipients vs Hemodialysis Patients

    D. Rodríguez-Espinosa, E. Montagud-Marrahi, J. Cacho, C. Arana, N. Taurizano, E. Hermida, J. Del Risco, J. Casals, A. Rosario, E. Cuadrado, N. Rodríguez, I. Revuelta, B. Bayès, P. Ventura-Aguiar, F. Cofan, E. Poch, F. Oppenheimer, M. Vera, L. Rodas, F. Maduell, F. Diekmann, A. Cases, J. Broseta, D. Cucchiari

    Nephrology and Renal Transplantation, Hospital Clinic of Barcelona, Barcelona, Spain

    *Purpose: The increased COVID-19 severity observed in kidney transplant recipients (KTR) has been widely reported. In addition, several studies have shown a reduced humoral and…
  • 2022 American Transplant Congress

    Higher Proinflammatory Cytokines Are Associated with Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients

    A. H. Karaba1, X. Zhu1, S. E. Benner1, O. Akinde1, Y. Eby1, K. H. Wang1, S. Saraf2, J. M. Garonzik-Wang3, S. L. Klein1, J. R. Bailey1, A. L. Cox1, J. N. Blankson1, C. M. Durand1, D. L. Segev1, W. A. Werbel1, A. A. Tobian1

    1Johns Hopkins University, Baltimore, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3University of Wisconsin School of Medicine and Health, Madison, WI

    *Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to…
  • 2022 American Transplant Congress

    Early Experience with Varicella Vaccination in Pediatric Heart Transplant Recipients

    A. Dipchand, M. Seifert-Hansen

    The Hospital of Sick Children, Toronto, ON, Canada

    *Purpose: International consensus guidelines to vaccinate children after transplant with varicella (VZV) vaccine exclude heart recipients due to insufficient evidence for safety, seroconversion rate, and…
  • 2022 American Transplant Congress

    Disparities in Low Respiratory Vaccination Among Solid Organ Transplant Recipients

    J. R. Felzer1, A. M. LeMahieu2, L. J. Finney Rutten2, Y. Juhn3, C. Wi3, R. M. Jacobson3, C. C. Kennedy1

    1Medicine, Mayo Clinic, Rochester, MN, 2Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 3Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN

    *Purpose: There are many potential infections post-transplant, with influenza as the most common vaccine-preventable infection the first 5 years post-transplant. Despite effective vaccines, uptake is…
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