Articles tagged "Vaccination"

2022 American Transplant Congress
COVID Infection Among Kidney Transplant Recipient During the Era of COVID Vaccination: Management Outcomes
G. Uehara, K. Soliman, V. Rao, M. Casey, D. Taber, M. Posadas Salas
Nephrology, Medical University of South Carolina, Charleston, SC
*Purpose: COVID pandemic has posed a significant challenge among kidney transplant recipients (KTR) due to their immunocompromised state. There is uncertainty on immunosuppression (IS) management…
2022 American Transplant Congress
Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, Z. Stewart¹, B. Lonze¹, M. Mangiola¹, C. DiMaggio¹, E. Weldon¹, I. Saeed¹, J. Leonard¹, R. Herati¹, J. Thomas¹, J. Michael¹, C. Hickson¹, K. Cartiera¹, R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY
*Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…
2022 American Transplant Congress
A Third Dose of SARS-CoV-2 Vaccine Increases Neutralizing Antibodies Against Variants of Concern in Solid Organ Transplant Recipients
A. H. Karaba¹, X. Zhu¹, T. Ling¹, K. H. Wang¹, A. G. Rittenhouse¹, O. Akinde¹, Y. Eby¹, J. E. Ruff¹, J. N. Blankson¹, A. T. Abedon¹, J. L. Alejo¹, A. L. Cox¹, J. R. Bailey¹, E. A. Thompson¹, S. L. Klein¹, D. S. Warren¹, J. M. Garonzik-Wang², B. J. Boyarsky¹, I. Sitaras¹, A. Pekosz¹, D. L. Segev¹, A. A. Tobian¹, W. A. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: Vaccine-induced SARS-CoV-2 antibody responses are attenuated in solid organ transplant recipients (SOTRs) and breakthrough infections are more common. Additional SARS-CoV-2 vaccine doses increase anti-spike…
2022 American Transplant Congress
Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared with One or Two Dose Vaccinated Solid Organ Transplant Recipients: A Multicenter, Matched Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Ramesh Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, J. Matelski², A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³Department of Medicine, UMontreal, Montreal, QC, Canada, ⁴Kidney Transplant Program, St. Michael's Hospital, Toronto, ON, Canada, ⁵Transplantation Unit, Renal division, Laval University, Quebec, QC, Canada, ⁶Division of Transplant Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Center of Saskatchewan, Saskatoon, SK, Canada, ⁸Hôpital Maisonneuve-Rosemont Research Institute, Montreal, QC, Canada, ⁹McGill University, Montreal, QC, Canada, ¹⁰Stollery Children's Hospital, Edmonton, AB, Canada
*Purpose: It is unknown if vaccine breakthrough COVID-19 infections are milder or as severe as infections in unvaccinated solid organ transplant (SOT) recipients.*Methods: We performed…
2022 American Transplant Congress
Impact of Immunosuppression on T-cell Responses After mRNA-Based Sars-CoV-2 Vaccination
E. Wong¹, N. L. Bert², H. K. Sran¹, A. Lim¹, M. D'Costa¹, K. Akalya², S. Hang², A. Bertoletti², A. Vathsala¹
¹National University Centre for Organ Transplantation, National University Hospital, Singapore, Singapore, ²Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore
*Purpose: Administration of mRNA-based SARS-CoV-2 vaccines confers protection from SARS-CoV-2 infection and reduces its severity in the general population. It has been suggested that mounting…
2022 American Transplant Congress
Safety and Immunogenicity of Live Viral Vaccination After Pediatric Liver and Kidney Transplantation
A. Feldman¹, B. Beaty¹, N. Ebel², J. Ferrolino³, V. Gopalareddy⁴, J. Hollenbeck⁵, C. Jaramillo⁶, N. Kerkar⁷, S. Lerret⁸, G. Maron³, A. Mavis⁹, N. Ovchinsky¹⁰, M. Sell¹¹, T. Sharma¹², J. Stoll¹³, L. Danziger-Isakov¹⁴
¹UCD, Aurora, CO, ²Stanford, Palo Alto, CA, ³St. Jude, Memphis, TN, ⁴LCH, Charlotte, NC, ⁵Michigan Medicine, Ann Arbor, MI, ⁶PCH, Salt Lake City, UT, ⁷URMC, Rochester, NY, ⁸MCW, Milwaukee, WI, ⁹Duke, Durham, NC, ¹⁰Montefiore, NYC, NY, ¹¹MUSC, Charleston, SC, ¹²BCH, Boston, MA, ¹³WUSM, St Louis, MO, ¹⁴CCHMC, Cincinnati, OH
*Purpose: New recommendations suggest that measles-mumps-rubella vaccine (MMR-vx) and varicella vaccine (VZV-vx) may be administered to certain non-immune transplant recipients. The purpose of this study…
2022 American Transplant Congress
Safety and Immunogenicity of BNT-162b2 versus Chadox1 Vaccine in Solid Organ Transplant Recipients: Prospective Study
A. Ajlan¹, T. Ali², H. Aleid², K. Almeshari², M. Alkaff³, S. Althuwaidi⁴, L. Fajji², A. Alali⁵, D. Halabi⁶, A. Ullah⁷, K. H. Marquez⁸, B. Elmikkaoui⁹, A. Alrajhi¹⁰, A. Zidan¹¹, E. Albogumi.¹², K. Bzeizi¹³, R. Almaghrabi¹⁴, E. DeVol¹⁵, M. Al-Awwami,¹⁶, S. Alghamdi¹³, P. Broering²
¹Pharmaceutical Care Division - Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riaydh, Saudi Arabia, ²Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ³Medical Laboratory, KFSHRC, Riaydh, Saudi Arabia, ⁴Medical Microbiology, KFSHRC, Riaydh, Saudi Arabia, ⁵Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁶Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁷Kidney & Pancreas Health Centre, KFSHRC, Riaydh, Saudi Arabia, ⁸Analytics Data Centre - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁹Data Management - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁰Infectious Diseases - Medicine Department, KFSHRC, Riaydh, Saudi Arabia, ¹¹Abdominal Transplant & Hepatobiliary Surgery Centre, KFSHRC, Riaydh, Saudi Arabia, ¹²Data Management. - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹³Liver & Small Bowel Health Centre, KFSHRC, Riaydh, Saudi Arabia, ¹⁴Infectious Diseases - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁵Biostatistics, Epidemiology &Scientific Computing, KFSHRC, Riaydh, Saudi Arabia, ¹⁶Histocompatibility and Immunogenetics Laboratory Kidney & Pa - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia
*Purpose: Data showed seroconversion after different SARS-CoV-2 vaccination platforms might yield diminished response in transplant recipients. However, it is unknown whether different vaccination platforms could…
2022 American Transplant Congress
Antibody Response to 3-Dose SARS-CoV-2 mRNA Vaccination in Pediatric Solid Organ Transplant Recipients
C. X. Qin¹, S. R. Auerbach², O. Charnaya¹, L. A. Danziger-Isakov³, N. H. Ebel⁴, A. G. Feldman², E. K. Hsu⁵, J. McAteer¹, S. Mohammad⁶, E. R. Perito⁷, A. M. Thomas¹, T. P. Chiang¹, J. M. Garonzik-Wang¹, D. L. Segev¹, D. B. Mogul¹
¹Johns Hopkins University, Baltimore, MD, ²University of Colorado, Aurora, CO, ³University of Cincinnati, Cincinnati, OH, ⁴Stanford University, Palo Alto, CA, ⁵University of Washington, Seattle, WA, ⁶Northwestern University, Chicago, IL, ⁷University of California San Francisco, San Francisco, CA
*Purpose: We report the immunogenicity and safety of a third BNT162b2 vaccine in pediatric solid organ transplant recipients (pSOTRs).*Methods: Samples from pSOTRs (12-18 years) enrolled…
2022 American Transplant Congress
Effect Of A Fourth Covid-19 Vaccine Dose On Omicron Variant Neutralization In Solid Organ Transplant Recipients
A. Karaba, A. Abedon, J. Alejo, C. X. Qin, D. Warren, J. Ruff, T. Aytenfisu, T. S. Johnston, O. Akinde, A. Pekosz, S. Klein, A. Cox, D. Segev, A. Tobian, W. Werbel
Johns Hopkins University, Baltimore, MD
*Purpose: Humoral response to COVID-19 vaccines is attenuated in many solid organ transplant recipients (SOTRs), necessitating additional primary and booster vaccinations. The omicron variant demonstrates…
2022 American Transplant Congress
Heterologous Vaccine Schedule Against Sars-CoV-2 with 2 Doses of Inactivated Virus and a Booster of mRNA BNT162b2 in Kidney Transplant Recipients
M. Seija¹, F. Rammauro², J. Santiago¹, N. Orihuela³, C. Zulberti³, D. Machado⁴, C. Recalde⁴, J. Noboa¹, R. Astesiano¹, F. Yandian¹, A. Guerisoli¹, A. Morra³, D. Cassinelli¹, A. Pippolo¹, B. De Aramburu¹, C. Coelho¹, P. González¹, R. Romero¹, R. Rodriguez-Teja⁴, G. Acuña⁴, V. Rabaza⁴, N. Perg⁴, R. Cordero⁴, S. Orihuela³, L. Curi³, E. Burgstaller⁴, O. Noboa¹, O. Pritsch², M. Nin¹, S. Bianchi⁵
¹Centro de Nefrología, Hospital de Clínicas. Facultad de Medicina UdeLaR, Montevideo, Uruguay, ²Departamento de Inmunobiología, Facultad de Medicina, UdeLaR, Montevideo, Uruguay, ³Hospital Italiano, Montevideo, Uruguay, ⁴Hospital Evangélico, Montevideo, Uruguay, ⁵Departamento de Fisiopatología, Facultad de Medicina UdeLar, Montevideo, Uruguay
*Purpose: Emerging evidence suggests that 3 doses of SARS-CoV-2 mRNA vaccine enhance immunity in kidney transplant (KT) patients. However, few studies have focused on humoral…