ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Transcription factors"

  • 2022 American Transplant Congress

    The Role of HNF4α in Renal Ischemia Reperfusion Injury

    A. D. Saha

    Toronto General Hospital Research Institute, Toronto, ON, Canada

    *Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…
  • 2022 American Transplant Congress

    Targeting the Bet Family Protein Brd4 Inhibits Inflammatory Macrophages and Promotes Heart Allograft Tolerance

    X. Xiao

    Surgery, Houston Methodist Hospital, Houston, TX

    *Purpose: Infiltration of allografts by inflammatory macrophages is frequently associated with chronic graft loss In both animal models and clinical settings, but the mechanisms that…
  • 2022 American Transplant Congress

    Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes

    C. M. Darden1, S. Vasu2, J. Mattke3, Y. Liu2, B. Naziruddin4, M. C. Lawrence2

    1Baylor University, Dallas, TX, 2Baylor University Medical Center, Dallas, TX, 3Baylor University, Waco, TX, 4Baylor University Medical Ctr, Dallas, TX

    *Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
  • 2022 American Transplant Congress

    A Novel Immunosuppressive Compound (79-6) That Targets Bcl6 Prevents the Humoral Alloresponse

    R. Kraaijeveld, D. A. Hesselink, C. C. Baan

    Internal medicine - Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: BCL6, is a transcription factor involved in B cell activation and differentiation. BCL6-expressing B cells play a crucial role in the development and maintenance…
  • 2022 American Transplant Congress

    Strada Deficiency Results in Inhibition of Tumor Suppressor Gene Liver Kinase B1 Resulting in Epithelial Mesenchymal Transition Leading to Chronic Murine Lung Allograft Rejection

    M. Rahman, S. Bansal, R. Ravichandran, A. Sureshbabu, W. Lie, S. Perincheri, M. Smith, R. Bremner, T. Mohanakumar

    St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Recently we demonstrated that tumor suppressor gene Liver Kinase B1 (LKB1) is down regulated in lung biopsies and in the circulating exosomes of lung…
  • 2021 American Transplant Congress

    Single Cell Rna-Sequencing of Urinary Cells and Defining the Immune Landscape of Rejection in Human Kidney Allografts

    T. Muthukumar1, H. Yang1, A. Belkadi2, G. Thareja2, C. Li1, C. Snopkowski1, K. Chen1, T. Salinas1, M. Lubetzky1, J. Lee1, D. Dadhania1, K. Suhre2, M. Suthanthiran1

    1Nephrology, NY Presbyterian- Weill Cornell Medical College, New York, NY, 2Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha, Qatar

    *Purpose: Transcriptome-based clustering of urinary cells in kidney transplant recipients may help identify cell-type specific injury and develop cell-type specific biomarkers for the noninvasive assessment…
  • 2021 American Transplant Congress

    Iguratimod Prevents Antibody-mediated Rejection by Regulating Germinal Center Formation and Antibody Production

    H. Zhang, A. Chandraker, P. Sage, N. Murakami

    Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: Antibody-mediated rejection (ABMR) is a major cause of chronic renal allograft failure without effective treatment, and developing a novel therapy is an urgent need.…
  • 2021 American Transplant Congress

    Naïve Rhesus Monkey CD4+CD8loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function

    M. Kubo, K. Sasaki, A. P. Gutiérrez, L. Lu, V. Vujevich, A. W. Thomson, M. Ezzelarab

    Department of Surgery, University of Pittsburgh, PITTSBURGH, PA

    *Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…
  • 2021 American Transplant Congress

    CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells

    O. Shaked1, J. Freimer1, J. Pritchard2, A. Marson1

    1UCSF, San Francisco, CA, 2Stanford University, Stanford, CA

    *Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…
  • 2021 American Transplant Congress

    Gene Expression Profiles Assessed by the Nanostring nCounter® Platform May Differentiate Different Types of Rejection, and Importantly, T-Cell Mediated Rejection from BK Virus Nephropathy

    K. R. Degner1, K. J. Swanson1, S. Parajuli1, D. Mandelbrot1, N. Garg1, F. Aziz1, M. Mohamed1, W. Zhong1, L. Ptak1, N. A. Wilson1, R. Woodward2, A. Djamali1

    1University of Wisconsin, Madison, WI, 2CareDx, Inc., San Francisco, CA

    *Purpose: Allograft biopsies are considered the gold standard for diagnosis and therapeutic guidance in kidney transplant recipients. Expanding current biopsy assessments to include gene expression…
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