2015 American Transplant Congress
Iron Deficiency Impairs Regulatory T Cell Induction
In a recent clinical trial of immunosuppression withdrawal in adult liver transplant recipients, operational tolerance was associated with development of a transient lymphocyte infiltration rich…2015 American Transplant Congress
TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction
Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…2015 American Transplant Congress
B-Cell Tolerance to Donor Alloantigens
Pre-existing panel-reactive antibodies and development of donor-specific alloantibodies are known to play important roles in graft dysfunction and deterioration. Preventing and/or eliminating alloantibody responses would…2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…2015 American Transplant Congress
Recipient Myelomonocytic Cells With Activated Hypoxia-Inducible Factor Alleviate Ischemia-Reperfusion Injury in Mouse Heart Allografts
Aim: To investigate the effect of HIF-1α and -2α activation in myelomonocytic cells during the early phase after ischemia-reperfusion (IRI) injury of mouse allogenic heart…2015 American Transplant Congress
Rejection of an Allograft Through Non-MHC Antigens Does Not Translate to the Rejection of a Different Allograft from the Same Donor in Mixed Chimeras
We previously showed that tolerance, induced by mixed chimerism in mice, is antigen-specific: tolerance of heart and skin allografts is dependent on Foxp3+ cells that…2015 American Transplant Congress
TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…2015 American Transplant Congress
Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients
Therapeutic cell transfer using regulatory T cells (Tregs) in transplant recipients may reduce the need for drug based immunosuppression (IS) and improve long term graft…2015 American Transplant Congress
CD8+TCR– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…2015 American Transplant Congress
A Novel Humanized Mouse Model for the Study of Induced Pluripotent Stem Cell-Derived Tissue Transplantation Tolerance and Function
Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.
Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine therapies, theoretically allowing for the creation of autologous replacement tissues devoid of many…
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