ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tolerance"

  • 2015 American Transplant Congress

    Stimulating Protease Inhibitor 9 Expression By Human Regulatory T Cells Improve Homeostasis

    P. Lukyanchykov, Z. Solhjou, A. Radwan, L. Riella, A. Chandraker, R. Abdi, J. Azzi.

    Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.

    In this study, we show for the first time the key role of a protease inhibitor PI9 in human regulatory T cells (Tregs) homeostasis. Recent…
  • 2015 American Transplant Congress

    Regulatory Tolerance Across a Full MHC Barrier Is More Robust Than Tolerance Across a Class I MHC Disparity Alone

    M. Madariaga, S. Michel, G. La Muraglia II, M. O'Neil, W. Orent, V. Villani, M. Sekijima, E. Farkash, R. Colvin, J. Allan, K. Yamada, J. Madsen, D. Sachs.

    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

    Background: We previously demonstrated that tolerance of hearts and/or kidneys achieved across a class I MHC mismatch with 12 days of CyA can be abrogated…
  • 2015 American Transplant Congress

    Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts

    M. Tonsho,1 G. Benichou,1 R. Smith,2 R. Colvin,2 J. Madsen.1,3

    1MGH Transplant Center, Massachusetts General Hospital, Boston, MA; 2Pathology, Massachusetts General Hospital, Boston, MA; 3Cardiac Surgery, Massachusetts General Hospital, Boston, MA.

    Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
  • 2015 American Transplant Congress

    Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys

    J. Weiner, Y. Kato, R. Duran-Struuck, M. Martinez, S. Baker, P. Alonso, J. Zitsman, A. Wu, P. Houck, T. Pinyavat, J. Lefkowitch, S. Chaudhry, T. Kato, M. Sykes, A. Griesemer.

    Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.

    IntroductionCombined kidney/bone marrow transplantation (CKBMT) induces tolerance in both primates and humans. Since liver is thought to be more tolerogenic than kidney, we hypothesized that…
  • 2015 American Transplant Congress

    Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells

    G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.

    Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.

    Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…
  • 2015 American Transplant Congress

    Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates

    H. Zhang,1 H. Guo,1 L. Lu,1 A. Zahorchak,1 R. Wiswman,2 G. Raimondi,1 D. Cooper,1 M. Ezzelarab,1 A. Thomson.1

    1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.

    Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…
  • 2015 American Transplant Congress

    Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance

    J. Chen, M. Daniels, D. Yin, R. Sciammas, A. Chong.

    Depart of Surgery, University of Chicago, Chicago.

    The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…
  • 2015 American Transplant Congress

    Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation

    C. Magee,1 M. Ohari,1 T. Shimizu,1 S. Ohori,1 N. Najafian,2 L. Riella.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Cleveland Clinic, Weston.

    Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…
  • 2015 American Transplant Congress

    Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations

    J. Mathew, X. Huang, J. Leventhal, L. Gallon, J. Miller, J. Levitsky.

    Surgery - Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…
  • 2015 American Transplant Congress

    Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex

    Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.

    Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

    Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
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