2015 American Transplant Congress
Changes in Health Related Quality of Life (HRQOL) in Pediatric Liver Transplant (LT) Recipients During Protocolized Immunosuppression Withdrawal (ISW): The iWITH Trial
ISW may limit medication-related comorbidities but intensive monitoring and unexpected rejection episodes may compromise HRQOL. We studied longitudinal HRQOL in pediatric LT recipients undergoing ISW…2015 American Transplant Congress
Identifying the “Operational Tolerant” Pediatric Liver Transplant Recipient by Cytometry by Time-of-Flight
Liver allografts are known to be well tolerated and indeed, some recipients of liver allografts retain stable graft function in the absence of immunosuppression. The…2015 American Transplant Congress
Vascularized Bone Marrow Plays a Critical Role in Inducing Tolerance of Osteomyocutaneous Allografts
Background: Vascularized composite allograft (VCA) that includes medullary bone may provide proposed benefits ofvascularized bone marrow transplantation (VBMT), such as a continuous supply of donor…2015 American Transplant Congress
A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA
Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…2015 American Transplant Congress
Identification of miRNAs Associated With Induced Tolerance to Allografts
Surgery-Transplantation, Stanford University School of Medicine, Stanford, CA.
Introduction: Although the liver is less immunogenic than other solid organs, most liver transplant recipients receive lifelong immunosuppression. Total lymphoid irradiation (TLI) is part of…2015 American Transplant Congress
Negative Effects of Being Obese or Overweight on T Regulatory (Treg) Cell Suppressive Function in Patients Listed for Lung Transplantation (Tx)
Aim: Obese and overweight patients may be prone to adverse outcomes following lung Tx. We sought to determine the relationship between body mass index (BMI)…2015 American Transplant Congress
IL-2/IL-2 Ab Complex Leads to Long-Term Tolerance in a Treg Dependent DST Model of Skin Allograft Transplantation in Which DST and Timing of the Antibody Complex Are Crucial
1Children's Hospital at Westmead, Sydney, Australia; 2Garvan Institute, Sydney, Australia.
Background: In vivo Treg expansion using IL2 complexed with anti-IL2 antibody has been demonstrated to be effective in the induction of long-term acceptance of islet…2015 American Transplant Congress
Kidney Plasmacytoid Dendritic Cells Display Distinct Cell Surface Markers and May Explain the Induction of Tolerance by Kidney Allografts
Massachusetts General Hospital, Boston, MA.
Achieving tolerance in heart allografts is an important area of research as the need for heart transplantations increase. Recent studies in non-human primates (NHPs) have…2015 American Transplant Congress
ECDI Fixed Donor Splenocytes Combined With α-1 Antitrypsin Induce Immune Tolerance in Mice Cardiac Transplantation Model
Our previous study have shown that infusions of donor splenocytes fixed with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI-SPs) could prolong allografts survival in mice cardiac transplantation model. However, proinflammatory…2015 American Transplant Congress
Operational Tolerance in Kidney Transplantation: Results of a Europe-Wide Survey
BACKGROUND: Operational Tolerance (opTOL) is deemed to be extremely rare in kidney transplantation. We launched a Europe-wide survey to assess the frequency of opTOL.METHODS: 18…
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