2015 American Transplant Congress
Hepatocyte-Related miR-193a-3p Is Over-Expressed in Allograft Biopsy from Liver Tolerant Recipients
While liver transplantation is the treatment of choice for end-stage liver diseases, its success is compromised by the need to administer life-long immunosuppression, which negatively…2015 American Transplant Congress
The Spleen Is the Primary Site for Breg Induction and Is Required for Anti-TIM-1 Mediated Tolerance
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
B cells can exhibit potent IL-10-dependent regulatory (Breg) activity. IL-10-enriched Bregs can transfer tolerance in auto and allo-immune models. We showed that TIM-1 is an…2015 American Transplant Congress
Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice
Background: Extracorporeal Photopheresis (ECP) is an immune therapy in which blood leukocytes are treated with 8-methoxypsoralen (8-MOP), exposed to UV-A light, and re-infused. This study…2015 American Transplant Congress
T Cell Transfer With iNKT Cell Activation Facilitate Engraftment of Bone Marrow Cells Without GvHD
Contamination of allogenic T cells is considered to be a risk factor of graft versus host disease (GvHD) in bone marrow transplantation (BMT), whereas it…2015 American Transplant Congress
Tolerant Kidney Transplant Patients Display B Cells With Regulatory Properties
Whereas a B cell transcriptional profile has been recorded for operationally tolerant kidney graft patients, the role that B cells may play in this process…2015 American Transplant Congress
Significant Association Between Foxp3 Gene Polymorphism and Outcomes in HBV-Related Liver Transplant Patients
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: Previous studies have demonstrated that CD4+Foxp3+ regulatory T (Treg) cells regulate HBV-related disease progression. The present study investigated the association between Treg cells and…2015 American Transplant Congress
Structure/Function Insights Into Treg Biology: Hdac11 Is a Foxp3 Deacetylase Whose Targeting Promotes and Stabilizes Foxp3 Expression and Leads to Long-Term Allograft Survival
1CHOP & UPenn, Philadelphia; 2Uni of Illinois at Chicago, Chicago.
Aim: There are huge scientific, economic and practical advantages in developing pharmacologic approaches to enhance Foxp3+ Treg function in allograft recipients versus simply injecting enormous…2015 American Transplant Congress
Human CD8+TCR– Facilitating Cells Enhance HSC Engraftment In Vivo and Promote HSC Survival In Vitro
CD8+/TCR- facilitating cells (FC) in mouse BM significantly enhance engraftment of hematopoietic stem cells (HSC) in syngeneic and allogeneic recipients. Human FC phenotype and mechanism…2015 American Transplant Congress
Proteomic Study Identified a Distinct Panel of Protein Expression in the ATP-Competitive MTOR Kinase Inhibitor Conditioned Dendritic Cells Compared to Rapamycin
Purpose: Dendritic cells (DCs) are key players in both innate and adaptive immunity, as well as in immune tolerance. The mammalian target of rapamycin (mTOR)…2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…
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