2015 American Transplant Congress
Impact of Human Mutant TGF-β1/Fc Protein On Memory and Regulatory CD4+T Cells Following Lymphodepletion in Rhesus Monkeys
Background:Tolerance to allografts is essential to avoid chronic immunosuppression and to promote long term graft function. Transforming growth factor- β plays a key role in…2015 American Transplant Congress
CD8+TCR– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…2015 American Transplant Congress
Economic Analysis of Kidney Transplant Tolerance: The Holy Grail Is Less Costly
Transplant Surgery, Massachusetts General Hospital, Boston, MA.
Introduction: Kidney transplantation (KTx), although expensive, is a more cost effective treatment for end-stage renal disease (ESRD) than dialysis, and provides better long term survival…2015 American Transplant Congress
IL-2/IL-2 Ab Complex Leads to Long-Term Tolerance in a Treg Dependent DST Model of Skin Allograft Transplantation in Which DST and Timing of the Antibody Complex Are Crucial
1Children's Hospital at Westmead, Sydney, Australia; 2Garvan Institute, Sydney, Australia.
Background: In vivo Treg expansion using IL2 complexed with anti-IL2 antibody has been demonstrated to be effective in the induction of long-term acceptance of islet…2015 American Transplant Congress
Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts
Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…2015 American Transplant Congress
T Cell Transfer With iNKT Cell Activation Facilitate Engraftment of Bone Marrow Cells Without GvHD
Contamination of allogenic T cells is considered to be a risk factor of graft versus host disease (GvHD) in bone marrow transplantation (BMT), whereas it…2015 American Transplant Congress
T Cell C5a Receptor (C5aR) Signaling Regulates T Follicular Helper Cell (Tfh) Induction
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Tfh cells, in part via IL-6 dependent production of IL-21, are specialized providers of B cell help. Extending previous work in which we showed that…
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