2015 American Transplant Congress
Stimulating Protease Inhibitor 9 Expression By Human Regulatory T Cells Improve Homeostasis
Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.
In this study, we show for the first time the key role of a protease inhibitor PI9 in human regulatory T cells (Tregs) homeostasis. Recent…2015 American Transplant Congress
Regulatory Tolerance Across a Full MHC Barrier Is More Robust Than Tolerance Across a Class I MHC Disparity Alone
Background: We previously demonstrated that tolerance of hearts and/or kidneys achieved across a class I MHC mismatch with 12 days of CyA can be abrogated…2015 American Transplant Congress
Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts
Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…2015 American Transplant Congress
Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
IntroductionCombined kidney/bone marrow transplantation (CKBMT) induces tolerance in both primates and humans. Since liver is thought to be more tolerogenic than kidney, we hypothesized that…2015 American Transplant Congress
Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells
Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…2015 American Transplant Congress
Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates
1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.
Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…2015 American Transplant Congress
Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance
Depart of Surgery, University of Chicago, Chicago.
The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…2015 American Transplant Congress
Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation
Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…2015 American Transplant Congress
Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations
Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…2015 American Transplant Congress
Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex
Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
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