Articles tagged "Tolerance"

2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
L. Wang,¹ A. Beeler,² S. Dahiya,¹ R. Han,¹ W. Hancock.¹
¹CHOP & UPenn, Philadelphia, PA; ²Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…
2016 American Transplant Congress
MicroRNA let-7i Regulates Dendritic Cells Maturation Targeting Interleukin-10 via JAK1-STAT3 Signal Pathway Subsequently Induces Prolonged Cardiac Allograft Survival in Rats.
X. Jin,¹ Y. Sun,² X. Liu,² J. Wang,¹ S. Xu,¹ L. Yao,¹ Z. Zhao,³ L. Jiang,⁴ Q. Wu,⁵ J. Wu.²
¹Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; ²Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ³Pediatric Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; ⁴Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Background:Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we investigated…
2016 American Transplant Congress
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.
L. Gallon,¹ J. Leventhal,¹ C. Dumur,² J. Mathew,¹ L. Nadimpalli,¹ A. Shetty,¹ S. Ildstad,³ V. Mas.²
¹Medicine/Nephrology, Northwestern University, Chicago, IL; ²Medicine/Nephology, University of Virginia Health System, Charlottesville, VA; ³Immunology, University of Louisville, Louisville, KT.
Organ transplantation relies upon nonspecific immunosuppressive (IS) agents to prevent graft rejection. However, IS drugs have significant toxicities and chronic rejection occurs despite their usage.…
2016 American Transplant Congress
Tolerance Induction with Donor Bone Marrow Transplantation in Kidney Transplantation.
H. Park,¹ N. Lee,¹ S. Lee,¹ G. Choi,¹ C. Kwon,¹ S. Kim,¹ J.-W. Joh,¹ M. Kim,² Y. Kwon,² S.-K. Lee.¹
¹Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea; ²Transplantation Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
Tolerance induction is considered to be a final goal in the field of organ transplantation. We have performed simultaneous bone marrow and kidney transplantation in…
2016 American Transplant Congress
Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.
J. Chen,¹ J. Yang,¹ A. Akl,¹ Q. Wang,¹ D. Yin,¹ R. Sciammas,² A. Chong.¹
¹Transplant Surgery, University of Chicago, Chicago, IL; ²Methodist Research Institute, Methodist Medical Center, Houston, TX.
The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…
2016 American Transplant Congress
HLA Identical Renal Transplant Tolerance Using Donor Hematopoietic Stems Cells (DHSC): Role of Immunoregulation.
J. Leventhal,¹ J. Mathew,¹ D. Salomon,² S. Kurian,² J. Friedewald,¹ L. Gallon,¹ X. Huang,¹ A. Tambur,¹ Y. Kanwar,¹ J. Charette,¹ M. Abecassis,¹ J. Miller.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²The Scripps Research Institute, La Jolla, CA.
Purpose: Despite being a “perfect match”, HLA-identical kidney transplants (HLA-Id KTx) are rejected without sufficient immunosuppression (IS), and hence can also benefit from tolerance induction.…
2016 American Transplant Congress
Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).
B. Motyka,¹ B. Lamarche,¹ K. Labonte,¹ S. Wang,¹ J. Pearcey,¹ K. Tao,¹ M. Mengel,¹ B. Sis,¹ P. Cowan,² L. West.¹
¹Alberta Transplant Institute/CNTRP, University of Alberta, Edmonton, Canada; ²Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.
Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…
2016 American Transplant Congress
Ex Vivo Expansion and Functional Characterization of Human Alloantigen-Specific Regulatory T Cells.
J. Mathew,¹ S. McEwen,¹ I. Konieczna,¹ X. Huang,¹ J. He,¹ R. Kornbluth,² J. Miller,¹ L. Gallon,¹ J. Leventhal.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Multimeric Biotherapeutics, Inc, La Jolla, CA.
Purpose: Regulatory T cells (Tregs) have been associated with clinical transplant tolerance and they have been shown to prolong graft survival in animal models without…
2016 American Transplant Congress
Clonal Expansion of Donor-Specific Tregs Following Combined Kidney and Bone Marrow Transplantation.
T. Savage,¹ S. Dewolf,¹ A. Obradovic,¹ S. Lau,¹ J. Zuber,¹ L. Turka,^2,3 Y. Shen,¹ M. Sykes.¹
¹Columbia University, New York; ²Massachusetts General Hospital, Boston; ³Immune Tolerance Network, Boston.
HLA-mismatched allograft tolerance was intentionally induced via combined kidney and bone marrow transplant (CKBMT) in two ITN protocols (NKDO3 and ITN036ST), but the mechanisms of…
2016 American Transplant Congress
Expansion of Regulatory B-Cells and Their Potential Role in Transplantation Tolerance.
B. Amundsen, H. Deirawan, J. Kim, J. Markmann.
Massachusetts General Hospital, Boston, MA.
IntroductionRegulatory B (Bregs) cells, B cells which produce IL-10, have been shown to play a critical role in immune homeostasis and autoimmunity models. Despite the…