2017 American Transplant Congress
B Cells in Liver Transplant Tolerance.
In mice liver transplantation, the liver allografts can be accepted across fully mismatched MHC without immunosuppression. After transplantation, T cells infiltrate into the graft in…2017 American Transplant Congress
SIRPα+ DCs and the Time-Dependent CD4+CD8+ Double Positive T Cell Infiltration in Accepted Renal Allografts.
IntroductionIn 2015 Overgaard and colleagues proposed that double positive T (DPT) cells, usually unique to the thymus, represent more than a developmental phase as extrathymic…2017 American Transplant Congress
Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.
Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…2017 American Transplant Congress
Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…2017 American Transplant Congress
Induction of Delayed Renal Allograft Tolerance Using Only Clinically Available Reagents in Non-Human Primates.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: We have previously reported successful induction of renal allograft tolerance following a period of conventional immunosuppression (Delayed tolerance) using nonmyeloablative conditioning that included anti-CD154…2017 American Transplant Congress
Importance of B Cell Antigen Specificity in Breg Dependent Tolerance.
Introduction: We have previously shown that anti-CD45RB induced islet and cardiac allograft tolerance is B cell dependent and can be adoptively transferred to naïve hosts…2017 American Transplant Congress
The Effect of Low-Dose IL-2 in Clinical Facial Transplantation: Molecular and Immunological Response.
1Brigham and Women's Hospital, Boston; 2Beth Israel Deaconess Medical Center, Boston
BackgroundRegulatory T cells (Tregs) play a critical role in immune tolerance and low-dose recombinant IL-2 administration has been reported to expand Tregs in vivo. Although…2017 American Transplant Congress
Tolerogenic Potential, Migratory Pathways, Engraftment and Long-Term Survival of Human Hematopoietic Chimeric Cells – A Novel Strategy to Induce Tolerance in Transplantation.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL
Background: Cell-based therapies represent a new promising strategy for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…2017 American Transplant Congress
Immunoregulatory Roles of CD137 Signaling in Graft-versus-Host Disease.
CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…2017 American Transplant Congress
Induction of Mixed Chimerism to Prolong Liver Allograft Survival in Cynomolgus Monkeys.
CCTI, Columbia University, New York, NY
Purpose: Spontaneous liver tolerance occurs in highly selected patients with stable liver function. There is an unmet need for a safe and reliable regimen allowing…
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