Articles tagged "Tolerance"

2017 American Transplant Congress
Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.
B. Gonzalez-Nolasco, J. Marino, W. Orent, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…
2017 American Transplant Congress
A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.
B. Motyka,¹ Y. Wang,¹ B. Lamarche,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; ²Dept Chemistry, Alberta Glycomics Centre, University of Alberta, Edmonton, Canada; ³Immunology Research Centre, St Vincent's Hospital, University of Melbourne, Melbourne, Australia
Purpose: In contrast to adults, ABO-incompatible heart transplantation (ABOi HTx) can safely be performed in infants due to absent/low levels of anti-A/B antibodies (Ab). Tolerance…
2017 American Transplant Congress
Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.
Y. Tomita,¹ W. Bracamonte-Baran,¹ E. Jankowska-Gan,¹ Q. Zhang,² D. Vignali,² W. Burlingham.¹
¹Surgery, Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Immunology, University of Pittsburgh, Pittsburgh
Introduction: We previously reported that donor specific splenocytes transfusion (DST) plus anti-CD40L costimulatory blockade treatment causes allo-specific regulation approximately 5 weeks after the tolerization. The…
2017 American Transplant Congress
Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.
P. Szabolcs,^1,2 X. Chen,¹ M. Hill.¹
¹BMT and Cell Therapy, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; ²Immunology, University of Pittsburgh, Pittsburgh, PA
The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…
2017 American Transplant Congress
Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.
Z. Zheng,¹ J. Wang,¹ X. Yeap,¹ L. Li,³ L. Zhang,² M. He,¹ X. Luo,² Z. Zhang.¹
¹Comprehensive Transplant Center and Department of Surgery, Chicago, IL; ²Division of Nephrology and Hypertension, Chicago, IL; ³Department of Pathology, Chicago, IL
Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…
2017 American Transplant Congress
Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.
I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), encoded by NOS2, is a hallmark of the innate immune axis, and is typically associated…
2017 American Transplant Congress
Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.
T. Kanzawa,¹ T. Hirai,¹ R. Ishii,¹ M. Okumi,¹ H. Ishida,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cluster for Industry Partnerships (CIP), RIKEN, Tokyo, Japan
Background: Allogeneic islet transplantation is an effective therapeutic option for type 1 diabetes. Toxicity associated with chronic use of immunosuppressants still remains an obstacle for…
2017 American Transplant Congress
A Novel Method for iNKT Cell-Mediated Ex Vivo Treg Expansion Applied to Induce Human Transplant Tolerance.
H. Katsumata,^1,2 M. Ikemiyagi,¹ S. Miyairi,¹ R. Ishii,¹ T. Kanzawa,¹ H. Fukuda,¹ T. Hirai,¹ M. Okumi,¹ Y. Ishii,³ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; ³Cluster for Industry Partnership (CIP), RIKEN, Yokohama, Japan
Background: Although regulatory T cells (Tregs) are beneficial for transplant-tolerance induction, decisive methods for their preferential expansion have not yet been established. In our series…
2017 American Transplant Congress
Impact of mTOR-Inhibition on Tolerance-Induction Following Heart Transplantation.
M.-T. Dieterlen, K. Klaeske, J. Fischer, J. Hahn, K. Jawad, J. Garbade, F. Mohr, S. Lehmann.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: The mammalian target of rapamycin (mTOR) is a central regulator of the immune system and therefore one target of immunosuppressive drug therapy. Tolerance-inducing properties…
2017 American Transplant Congress
Dual Costimulatory Blockades Failed to Achieve Transplant Tolerance Despite Induction of Mixed Chimerism in NHPs.
T. Oura,¹ K. Hotta,¹ I. Rosales,² A. Dehnadi,¹ J. Lei,¹ J. James Markmann,¹ M. Matsunami,¹ J. Paster,¹ I. Hanekamp,¹ K. Pruner,¹ K. Kawai,¹ D. Ndishabandi,² R.-N. Smith,² B. Cosimi,¹ T. Kawai.¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA
Background: Our previous studies showed that substantial deletion of CD8+ memory T cells (TMEM) was necessary to induce mixed chimerism (MC) and allograft tolerance when…