Articles tagged "Tolerance"

2017 American Transplant Congress
iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.
R. Ishii,¹ T. Hirai,¹ Y. Ishii,² M. Okumi,¹ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cluster for Industry Partnerships (CIP), RIKEN, Yokohama, Japan
Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…
2017 American Transplant Congress
Preservation of Musculoskeletal Components in Vascularized Composite Allograft Skin Rejection.
E. Buckingham, A. Khalifeh, M. Uluer, W. Hassenein, C. Drachenberg, A. Nam, W. Twaddell, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD
Background: Severe or chronic rejection of vascularized composite allografts (VCA) has resulted in graft loss and patient deaths. 'Split tolerance' has been defined in patterns…
2017 American Transplant Congress
Preventing Alloimmune Rejection in Heart Transplantation by Tolerogenic Dendritic Cells Induced by GDF15 Through Up-Regulation of IDO and Inhibition of the NFκB Signalling Pathway.
Y. Zhang,^1,3 G. Zhang,¹ L. Moszczynski,¹ D. Zhao,^1,3 P. Abulizi,¹ D. Quan,² T. Mele,² K. Liu,³ X. Zheng.^1,2
¹Pathology, University of Western Ontario, London, ON, Canada; ²Surgery, University of Western Ontario, London, ON, Canada; ³Cardiovascular Surgery, Jilin University, Cahngchun, China
Rationale: Growth differentiation factor 15 (GDF15) can inhibit DC maturation, yet whether it can generate tolerogenic dendritic cells (Tol-DCs) to induce immune tolerance in heart…
2017 American Transplant Congress
Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates.
K. Hotta, T. Oura, A. Dehnadi, K. Huh, M. Matsunami, G. Benichou, J. Madsen, A. Cosimi, T. Kawai.
Center for Transplant Science, Massachusetts General Hospital, Boston, MA
Background: We have previously reported donor specific expansion of regulatory T cells (Tregs) in nonhuman primate (NHP) recipients which achieved renal allograft tolerance after induction…
2017 American Transplant Congress
Novel Personalized Immune-Monitoring Assay for Predicting Operational Tolerance by Using Humanized Mouse Model.
Y. Fukasaku,¹ R. Goto,¹ Y. Ganchiku,¹ M. Zaitsu,¹ M. Watanabe,¹ N. Kawamura,¹ Y. Koshizuka,¹ K. Yamashita,² T. Shimamura,³ A. Taketomi.¹
¹Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan; ²Transplant Surgery, Hokkaido University, Sapporo, Japan; ³Division of Organ Transplantation, Hokkaido University, Sapporo, Japan
Background: Biomarkers and immune-monitoring assays predicting operational tolerance in transplant recipients have not been established. Our aim was to develop an immune-monitoring assay to address…
2017 American Transplant Congress
A Regulatory T Cell (Treg)-Intrinsic Role for p27kip1 in Acquired Transplant Tolerance.
P. Morawski, L. Wang, X. Yang, Y. Chen, W. Hancock, A. Wells.
Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA
We previously found that the cyclin-dependent kinase CDK2 phosphorylates the Treg transcription factor Foxp3, targeting it for proteolytic degradation. Treg with defective CDK2 activity express…
2017 American Transplant Congress
PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.
M. Climov, M. Uehara, Z. Solhjou, H. Matsumine, N. Bouyani, E. Kefaloyianni, B. Basmani, V. Kasinath, G. Giatsidis, D. Orgill, R. Abdi.
Brigham and Women's Hospital, Boston, MA
Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…
2017 American Transplant Congress
A Clinically Relevant Protocol for Vascularized Composite Allotransplantation Using a Single Dose of AMD3100 for Stem Cell Mobilization.
B. Swearingen,^1,2 S. Graves,^2,3 R. Storb,^2,3 D. Mathes.^1,2
¹Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; ²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ³Medicine, University of Washington Medical Center, Seattle, WA
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but application is limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols…
2017 American Transplant Congress
The Intragraft Vascularized Bone Marrow Component and Recipient T Regulatory Cells Facilitate Tolerance Induction After Post Transplant High Dose Cyclophosphamide Treatment in VCA.
G. Furtmüller, B. Oh, M. Fryer, S. Ganguly, V. Malek, X. Zhou, J. Dodd-o, G. Raimondi, D. Cooney, C. Brayton, W. Lee, L. Luznik, G. Brandacher.
Johns Hopkins University School of Medicine, Baltimore, MD
Background: VCA is a viable treatment option for devastating tissue defects. However, the life-long need for immunosuppression curtails the wider use of VCA. Unique VCA-features…
2017 American Transplant Congress
Autotransplantation of the Left Lung for the Treatment of Recurrent Life Threatening Pulmonary Hemorrhage Related to Pulmonary Vascular Malformation: A Unique Chance to Study Ischemia/Reperfusion Injury.
C. Falk,¹ I. Tudorache,² C. Müller,³ W. Sommer,² K. Daemen,¹ J. Keil,¹ G. Hansen,³ A. Haverich,² G. Warnecke,² N. Schwerk.³
¹Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany; ²Department of Cardiothoracic Transplant and Vascular Surgery, MHH, Hannover, Germany; ³Department of Pediatric Pneumology, MHH, Hannover, Deutschland, Germany
Background: Ischemia reperfusion injury (IRI) remains a major clinical problem in lung transplantation. Here, we report the investigation of IRI in a 17-year-old patient who…