Articles tagged "Tolerance"

2018 American Transplant Congress
Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.
G. Furtmüller,¹ B. Oh,¹ J. Sidhom,² M. Fryer,¹ V. Malek,¹ X. Zhou,¹ D. Cooney,¹ C. Brayton,³ J. Dodd-o,⁴ S. Ganguly,² G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD; ³Department for Comparative Pathobiology, Johns Hopkins University, Baltimore, MD; ⁴Department of Anesthesiology, Johns Hopkins University, Baltimore, MD.
Background: Treatment with PT/Cy in the setting of combined donor bone marrow transplantation and VCA has shown encouraging results with regards to chimerism induction and…
2018 American Transplant Congress
Effect of Erythropoietin on Cardiac Allograft Survival in Non-Human Primates
J. O.,¹ K. Robinson,¹ W. Sommer,¹ K. Pruner,¹ J. Paster,¹ M. Hanekamp,¹ A. Dehnadi,¹ I. Rosales,¹ R. Smith,¹ P. Cravedi,² P. Heeger,² G. Benichou,¹ J. Madsen.¹
¹MGH, Boston; ²Icahn School of Medicine at Mount Sinai, New York.
Purpose: Tolerance of cardiac allografts has been achieved in cynomolgus monkeys for the first time via mixed hematopoietic chimerism and donor kidney co-transplantation, but the…
2018 American Transplant Congress
T Cell Lineage Imbalance and Regulatory Immune Populations in HCC Patients Undergoing Downstaging While Waitlisted for Liver Transplantation
P. Thevenot,¹ K. Nunez,¹ T. Sandow,² J. Gimenez,² J. Gonzalez-Rosario,¹ M. Patel,¹ A. Alfadhli,¹ D. Wyczechowska,³ A. Cohen.¹
¹Institute of Translational Research, Ochsner Health System, New Orleans, LA; ²Interventional Radiology, Ochsner Health System, New Orleans, LA; ³Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Purpose:In this study, we monitored peripheral lymphocyte lineage and regulatory immune populations in HCC patients undergoing DEB-TACE as a bridge to liver transplantation.Methods: Liver transplant…
2018 American Transplant Congress
Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model
S. Tullius,¹ Y. Kumamoto,² U. Nalan.³
¹Department of Medicine, Brigham and Women's Hospital, Boston, MA; ²Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; ³Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.
Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…
2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
J. Gardner,¹ A. Posselt,¹ S. Wisel,¹ U. Mashirani,² G. Szot,¹ V. Nguyen,¹ K. Johnson,¹ J. McElroy,¹ Q. Tang,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Endocrinology, University of California, San Francisco, San Francisco, CA.
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…
2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹
¹Immunology, Stanford School of Medicine, Stanford, CA; ²Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; ³Nephrology, Stanford School of Medicine, Stanford, CA; ⁴Surgery, Stanford School of Medicine, Stanford, CA; ⁵Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73^HIFR4^HIPD1⁺ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
A. Dangi,¹ L. Zhang,¹ X. Zhang,² X. Luo.^1,2
¹Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
2018 American Transplant Congress
Ex-Vivo Generation of Alloantigen-Specific Immunomodulatory Cells: Elucidating the Mechanistical Synergy of Cell Components
M. Yao,¹ M. Kumagai-Braesch,¹ M. Watanabe,^1,2 K. Tokodai,¹ T. Lundgren,¹ M. Uhlin,¹ B. Ericzon.¹
¹Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden; ²Transplantation, Hokkaido University Hospital, Sapporo, Japan.
IntroductionRecently, Todo et al. reported that ex-vivo generated immunomodulatory cells induced operational tolerance in 7/10 liver transplanted recipients. To allow wide spread application, it is…
2018 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine Model
B. Swearingen,^1,2 S. Graves,^2,3 R. Storb,^2,3 D. Mathes.^1,2
¹Surgery; Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; ²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ³Medicine, University of Washington Medical Center, Seattle, WA.
PURPOSE:Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by chronic immunosuppression and rejection. Current clinical tolerance protocols rely on recipient conditioning and…
2018 American Transplant Congress
Donor Bone Marrow CXCR4+ Foxp3+ Treg Cells Are Essential for Costimulation Blockade-Induced Long-Term Survival of Murine Limb Transplants
L. Wang,¹ Z. Wang,¹ R. Han,¹ G. Ge,¹ L. Levin,² M. Levine,² W. Hancock.^1,2
¹CHOP, Philadelphia; ²UPenn, Philadelphia.
Vascularized composite allotransplantation (VCA) would likely be more widely performed if maintenance immunosuppression was not essential for graft acceptance. Accordingly, we used murine models of…