Articles tagged "Tolerance"

2019 American Transplant Congress
Persistent Mixed Chimerism, Immune Reconstitution, and Tolerance in Recipients of HLA Matched Kidney and Hematopoietic Cell Transplants
S. Busque, J. Scandling, R. Lowsky, J. Shizuru, E. Meyer, K. Jensen, A. Shori, R. Hoppe, E. Engleman, T. Pham, S. Strober
Stanford University School of Medicine, Stanford, CA
*Purpose: We evaluated the immune reconstitution of recipients of HLA matched combined kidney and hematopoietic cell transplants after tolerance induction*Methods: Twenty nine recipients of living…
2019 American Transplant Congress
High Fibre Diet Prevents Transplant-Associated Dysbiosis and Prevents Kidney Allograft Rejection
J. J. Singer¹, H. Wu¹, T. Kwan¹, Y. Loh¹, C. Wang¹, J. Tan², L. Macia², S. Alexander³, S. Chadban¹
¹Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, Sydney, Australia, ²Nutritional Immunometabolism Lab, Charles Perkins Centre, The University of Sydney, Sydney, Australia, ³The Children's Hospital Westmead, Sydney, Australia
*Purpose: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid (SCFA) sodium acetate (SA) on kidney…
2019 American Transplant Congress
Efficacy of Photobiomodulatory Therapy Combined with Short-Term Immunosuppressants Prolonged Allograft Survival in a Rodent Hind-Limb Model
Y. KUO¹, Y. Li¹, C. Chen¹, R. Chen1¹, G. Brandacher²
¹Division of Plastic Surgery, Department of Surgery,, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ²Department of Plastic Surgery, VCA center, Johns Hopkins University, Baltimore, MD
*Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…
2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
E. Bernaldo de Quirós¹, R. López¹, V. Pérez¹, M. Clemente², J. Gil-Jaurena³, M. Camino⁴, N. Gil⁴, E. Panadero⁴, C. Medrano⁴, M. Pion¹, R. Correa-Rocha¹
¹Laboratory of Immune-regulation, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ²Cell Culture Unit, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ³Pediatric Cardiac Surgery Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Pediatric Cardiology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…
2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
P. K. Gupta¹, M. L. Miller², L. Chen¹, Y. Wang¹, J. Conejo-Garcia³, A. Chong¹, M. Alegre¹
¹University of Chicago, Chicago, IL, ²University of Pittsburgh, Pittsburgh, PA, ³Moffitt Cancer Center & Research Institute, Tampa, FL
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…
2018 American Transplant Congress
Donor Bone Marrow CXCR4+ Foxp3+ Treg Cells Are Essential for Costimulation Blockade-Induced Long-Term Survival of Murine Limb Transplants
L. Wang,¹ Z. Wang,¹ R. Han,¹ G. Ge,¹ L. Levin,² M. Levine,² W. Hancock.^1,2
¹CHOP, Philadelphia; ²UPenn, Philadelphia.
Vascularized composite allotransplantation (VCA) would likely be more widely performed if maintenance immunosuppression was not essential for graft acceptance. Accordingly, we used murine models of…
2018 American Transplant Congress
Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression
S. Eskandari,¹ M. Bandeira Melo,² J. Assaker,¹ A. Mansouri,¹ S. Cai,¹ B. Al Dulaijan,¹ M. Mohamed,¹ D. Irvine,² J. Azzi.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.
Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…
2018 American Transplant Congress
Lymph Node Reprogramming: Microparticle Delivery of Immune Signals to Induce Tolerance and Prolong Allograft Survival
Y. Xiong,¹ L. Tostanoski,² C. Jewell,² J. Bromberg.¹
¹UMB, MD; ²UMCP, MD.
Introduction: Microparticle (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either pro-inflammatory or anti-inflammatory…
2018 American Transplant Congress
TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival
L. Wang, A. Samanta, R. Han, N. Zhou, W. Hancock.
Path & Lab Med, CHOP & UPenn, Philadelphia, PA.
Given the major roadblocks to development of Treg-based cell therapy, pharmacologic approaches to expand endogenous Tregs warrant attention, including approaches with more sustained effects than…
2018 American Transplant Congress
In Vitro α-Galactosylceramide Stimulation Expands CD4⁺CD25⁺Foxp3⁻ Regulatory T Cell Precursors in Murine Thymocytes
H. Katsumata,^1,2 M. Ikemiyagi,¹ T. Kanzawa,¹ H. Fukuda,¹ R. Ishii,¹ K. Saiga,^1,3 M. Okumi,¹ Y. Ishii,⁴ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; ³Urology, Jyoban Hospital of Tokiwa Foundation, Fukushima, Japan; ⁴Laboratory for Immunotherapy, Center for Integrative Medical Sciences (IMS) RIKEN, Yokohama, Japan.
Background: We previously established mixed chimerism after invariant natural killer T-cell stimulation by administration of liposomal α-galactosylceramide (lipo-αGC) and costimulatory blockade, leading to regulatory T…