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American Transplant Congress abstracts

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Articles tagged "Tolerance"

  • 2019 American Transplant Congress

    Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants

    S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor

    Rabin Medical Center, Petah-Tiqwa, Israel

    *Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
  • 2019 American Transplant Congress

    Interruption of Notch Signaling via Blockade of Delta-Like Ligands 1 and 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

    A. Matar, Y. Dong, B. Lovasik, D. Mathews, A. Ghosh, C. Breeden, A. Stephenson, W. Kitchens, A. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
  • 2019 American Transplant Congress

    After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance

    T. Kawai1, D. H. Sachs1, T. Spitzer1, N. Tolkoff-Rubin1, R. B. Colvin1, N. Elias1, M. Sykes2, A. Cosimi1

    1Massachusetts General Hospital, Boston, MA, 2Columbia University, NYC, NY

    *Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…
  • 2019 American Transplant Congress

    Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo

    Y. Xiong, L. Wang, R. Han, W. W. Hancock

    Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…
  • 2019 American Transplant Congress

    T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance

    C. M. McIntosh1, M. L. Miller2, Y. Wang1, A. Chong3, M. Alegre1

    1Department of Medicine, University of Chicago, Chicago, IL, 2Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 3Department of Surgery, University of Chicago, Chicago, IL

    *Purpose: Donor-specific tolerance offers many advantages over current lifelong non-specific immunosuppression strategies, but the mechanisms by which it may be durably maintained remain to be…
  • 2018 American Transplant Congress

    DAP12 and Its Triggering Co-Receptor TREM2 Play Key Roles in Regulation of Mouse and Human Liver DC Function and Control of Liver Ischemia-Reperfusion Injury

    T. Nakao,1 Y. Ono,1 H. Dai,1 A. Perez-Gutierrez,1 G. Camirand,1 H. Huang,1 D. Geller,1,2 A. Thomson.1,3

    1Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA; 3Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background: Liver interstitial dendritic cells (DCs) have been implicated in the control of liver ischemia/reperfusion injury (IRI) and in the induction of liver transplant tolerance.…
  • 2018 American Transplant Congress

    Transplantation Tolerance Prevents CMV Reactivation and Preserves Kidney Allograft Function in a D+/R- Transplant Setting

    A. Dangi,1 J-.J. Wang,2 M. Burnette,1 Z. Zhang,2 X. Luo.1,2

    1Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.

    Background: Immune responses to cytomegalovirus (CMV) infection may precipitate acute/chronic graft rejection in immunocompromised transplant recipients. CMV infection can be primary or its reactivation from…
  • 2018 American Transplant Congress

    Development of Post-Transplant DSA Following Immunosuppression Minimization/Withdrawal in Liver Transplant Recipients

    V. Jucaud,1 A. Shaked,2 M. DesMarais,3 P. Sayre,3 M. Everly.1

    1Terasaki Research Institute, Los Angeles; 2University of Pennsylvania, Philadelphia, PA; 3Immune Tolerance Network, Seattle, WA.

    Despite the allograft-risk associated with DSA, the development of post-transplant HLA donor-specific antibody (DSA) is not well described in liver transplant (LT) patients undergoing immunosuppression…
  • 2018 American Transplant Congress

    High Fibre Diet Induces Donor Specific Kidney Allograft Tolerance in Mice

    H. Wu,1,2 T. Kwan,2 Y. Loh,2 C. Wang,2 L. Macia,2 S. Alexander,2,3 S. Chadban.1,2

    1Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; 2University of Sydney, Sydney, Australia; 3The Children Hospital at Westmead, Sydney, Australia.

    Aim: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid sodium acetate (SA) on kidney allograft…
  • 2018 American Transplant Congress

    α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts

    G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…
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