Articles tagged "Tolerance"

2019 American Transplant Congress
Depleting Laminin α5 in Lymph Node Stromal Cells Promotes Transplant Tolerance
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, N. Toney, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Expression of stromal laminin α5β1γ1 (511) in lymph nodes (LN) is associated with immunity, while laminin α4β1γ1 (411) is associated with tolerance. The laminins…
2019 American Transplant Congress
Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes
B. Gonzalez Nolasco¹, M. Wang¹, W. Orent¹, A. Prunevieille¹, J. O¹, K. Ahrens¹, J. C. Madsen², G. Benichou¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Novel Oral Anticoagulants in Kidney Transplantation: Results from a Pilote Study
J. Leon, J. Zuber, L. Amrouche, D. Anglicheau, G. Divard, C. Legendre, R. Sberro-Soussan
Adult Transplantation, Necker Hospital, Paris, France
*Purpose: Oral anticoagulation therapy is frequently prescribed to kidney transplant recipients, for prevention and treatment of thrombotic events. Over the past ten years, novel oral…
2019 American Transplant Congress
B7H1 Expression is Crucial for Tolerance Induction in Mouse Liver Transplantation
M. Morita¹, S. Datta¹, C. Miller², T. Hamilton¹, K. Hashimoto³
¹Inflammation & Immunity, Lerner Research Institution, Cleveland, OH, ²General surgery, Liver Transplant Center, Cleveland Clinic, Cleveland, OH, ³General Surgery, Liver Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Following organ transplantation, lifelong immunosuppressive treatment is required and it causes severe side effects. Induction of donor specific tolerance is ideal, which actually spontaneously…
2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
2019 American Transplant Congress
Granulocyte – Colony Stimulating Factor (G-CSF) and Granulocyte – Macrophage Colony Stimulating Factor (GM-CSF) Administration Augments the Incidence of Peripheral Blood Suppressive Regulatory T Cells in Nonhuman Primates
K. Sasaki, Y. Wang, L. Lu, J. Hughs, A. W. Thomson, M. B. Ezzelarab
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF) are known to mobilize immune cells to the peripheral blood. We evaluated regulatory T cells (Treg)…
2019 American Transplant Congress
Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity
S. K. Eskandari¹, M. B. Melo², I. Sulkaj¹, N. Li², S. Cai¹, H. Allos¹, J. Y. Choi¹, D. J. Irvine², J. R. Azzi¹
¹Harvard Medical School, Brigham and Women's Hospital, Boston, MA, ²David H. Koch Institute for Integrative Cancer Research, Cambridge, MA
*Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…
2019 American Transplant Congress
A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance
R. M. Thomas, L. Wang, W. W. Hancock, A. D. Wells
The Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Ikaros is a transcriptional repressor encoded by the Ikzf1 gene that was recently identified as the pharmacologic target of thalidomide analogs in successful therapy…
2019 American Transplant Congress
Donor Brain Death Affects Tolerance Induction in Non-Human Primates
W. Sommer¹, J. M. O², K. B. Pruner³, J. T. Paster³, A. Bean³, A. Dehnadi³, I. M. Hanekamp³, I. Rosales⁴, R. N. Smith⁴, R. B. Colvin⁴, G. Benichou³, J. S. Allan³, T. Kawai³, J. C. Madsen⁵
¹Department of Cardiothoracic Surgery, Hannover Medical School, Hannover, Germany, ²Center for Transplantation Sciences, Massachusets General Hospital, Boston, MA, ³Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁴Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁵Center fro Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Induction of durable allograft acceptance in combined heart/kidney transplantation in non-human primates is possible by applying a mixed chimerism-based conditioning protocol. However, the impact…