Articles tagged "Tolerance"

2019 American Transplant Congress
Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model
J. H. Voss¹, F. Zheng¹, M. D. Jendrisak², J. R. Leventhal¹, Z. J. Zhang¹, J. M. Mathew¹
¹Surgery – Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Gift of Hope Organ & Tissue Donor Network, Itasca, IL
*Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…
2019 American Transplant Congress
Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations
K. Lee, J. Park, Y. Chung, S. Kim
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
2019 American Transplant Congress
Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells
A. Dangi¹, E. B. Thorp², X. Luo¹
¹Medicine, Duke University, Durham, NC, ²Pathology, Northwestern University, Chicago, IL
*Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…
2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
W. Piao¹, L. Li², V. Saxena², Y. Xiong², C. Paluskievicz², J. Bromberg³
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, Baltimore, MD, ³Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…
2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
L. Contreras-Ruiz¹, K. Shimozawa², R. Zhang¹, L. Turka³, J. F. Markmann³, E. C. Guinan²
¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ²Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Center of Transplantation Sciences, Massachussetts General Hosp., Boston, MA
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…
2019 American Transplant Congress
Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Costimulation blockade-based regimens are a promising strategy to promote transplant tolerance. However, their efficacy is affected by multiple factors, many of which remain unknown.…
2019 American Transplant Congress
Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski¹, V. Rojas-Luengas¹, S. Moshkelgosha¹, J. Luo², H. Yowanto², Z. Galvin¹, L. Lilly¹, R. Smith¹, E. Renner¹, J. Zhang¹, D. Grant¹, O. Adeyi¹, H. Atkins³, P. Juni⁴, N. Selzner¹, S. Juvet¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Sciex, Brea, CA, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
*Purpose: Previously we reported a novel biomarker gene set for the identification of tolerance in murine models of rapamycin-induced cardiac tolerance and spontaneous hepatic tolerance.…
2019 American Transplant Congress
Tolerance Induction by Myeloid Progenitor Cells Modulates T and B Cell Responses
J. Domen, Y. Li
Allergy, Asthma and Immunology, Children's Mercy Hospital, Kansas City, MO
*Purpose: Modulation of the immune system using cellular therapy is an increasingly attractive option to prevent solid organ graft rejection, while at the same time…
2019 American Transplant Congress
Novel Flow-Based Assay to Identify Allo-Specific T Cell Exhaustion
N. Tanimine¹, C. Rickert¹, K. Lee¹, K. Deng¹, N. Feeney¹, C. Leguern¹, B. Burrell², J. Markmann¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Immune Tolerance Network, Bethesda, MD
*Purpose: A recent, multi-center immunosuppression withdrawal trial in liver transplant recipients unexpectedly revealed time post-transplant as an important predictor for operational tolerance. We hypothesize that…
2019 American Transplant Congress
Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation
J. Zuber¹, O. Boyer¹, B. Neven¹, E. Six², R. Berthaud¹, M. Ould Rabah¹, S. Sobrino², C. Lagresle², I. André-Schmutz², M. Cavazzana¹, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Inserm UMRS 1163, Paris, France
*Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…