Articles tagged "Tolerance"

2020 American Transplant Congress
HLA Molecular Mismatch Analysis in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplant Tolerance Induction Protocol
C. Garcia-Sanchez¹, V. Kosmoliaptsis², H. Copley², J. Leventhal¹, S. Ildstad³
¹NU, Chicago, IL, ²Cambridge, Cambridge, United Kingdom, ³U of Louisville, Lousville, KY
*Purpose: To evaluate the potential role of HLA molecular mismatch (MM) analysis in predicting outcomes in a cohort of HLA-mismatched, related and unrelated recipients of…
2020 American Transplant Congress
High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction
R. Bellmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. Bläsing¹, F. Ius², W. Sommer², J. Kühne¹, L. Horn¹, A. Knöfel², I. Tudorache², A. Haverich², D. Jonigk³, G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, ³Institute of Pathology, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
2020 American Transplant Congress
Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways
X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
2020 American Transplant Congress
Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. S. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…
2020 American Transplant Congress
Plasma Cells Are Not Necessary for Regulatory B Cells and Preventing Their Differentiation Markedly Prolongs Allograft Survival
W. Yuan, Q. Ding, D. Rothstein
Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Plasma Cells (PCs) are the primary source of circulating antibodies. PCs were reported to be the major source of B-cell lineage IL-10, and absence…
2020 American Transplant Congress
The Requirement of Thymic Irradiation for Induction of Mixed Chimerism and Renal Allograft Tolerance in Non-Human Primates
T. Hirose¹, H. Sasaki¹, T. Oura¹, D. Ma¹, A. Dehnadi¹, R. B. Colvin², I. Rosales², A. B. Cosimi¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: Thymic irradiation (TI) has been required for consistent induction of allograft tolerance through a mixed chimerism approach in both murine and nonhuman primate (NHP)…
2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
J. M. Mathew¹, S. Lee², Y. Sambandam¹, L. A. Fraser², T. D. Clemons², A. Kolberg², J. He¹, L. C. Palmer², M. T. McClendon², Z. J. Zhang¹, J. R. Leventhal¹, S. I. Stupp², L. Gallon¹
¹Surgery -Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…