Articles tagged "Tolerance"

2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
P. M. Patel¹, B. A. Gonzalez Nolasco¹, J. A. Morrissette¹, A. Prunevieille¹, K. J. Ahrens¹, J. M. O¹, D. C. Becerra¹, G. Benichou¹, J. C. Madsen²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
2020 American Transplant Congress
Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Bruestle¹, F. Fredriksson¹, J. Stern¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…
2020 American Transplant Congress
IL-21, a Potential Target of Active Rejection in Renal Transplantation
J. Shen, R. Wang, L. Guo, J. Lv, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Rejection remains an obstacle to overcome after transplantation. IL-21 is the most potent stimulators of driving GC B cells into plasma cells. Basic researches…
2020 American Transplant Congress
TGF-b Induced Myeloid-Derived Suppressor Cells Prevent Transplatation Rejection by Promoting Immune Tolerance
P. Cao, Z. Sun, J. Zhang, F. Zhang, W. Wang
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a class of heterogeneous myeloid cells with immunosuppressive function. An effective method to produce MDSCs with better capacity and…
2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
2020 American Transplant Congress
Plasma Microbiome Profiles of Liver Transplant Patients with Operational Tolerance
C. Kuscu¹, J. Pierre², I. Lies¹, C. Kuscu¹, A. Bajwa¹, A. Wolen¹, J. Eason¹, B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹James D. Eason Transplant Institute, Department of Surgery, UTHSC, Memphis, TN, ²Department of Pediatrics, UTHSC, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, UPMC, Pittsburgh, PA
*Purpose: Microbiome has emerged as a key modulator of organ homeostasis and immune system function with altered microbiota and microbiome - host interactions contributing to…
2020 American Transplant Congress
Prognostic Value of Dd-cfDNA Assay in Acute Renal Rejection Therapy: A Prospective Cohort Study
L. Guo, R. Wang, J. Lv, J. Shen, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Donor-derived cell free DNA (dd-cfDNA) is a promising biomarker for monitoring allograft status. However, whether it is capable of reflecting real time anti-rejection treatment…
2020 American Transplant Congress
Single Cell RNA Sequencing Analysis of 3 Human Living-Donor Liver Transplant Allograft Biopsies after Infusion of Donor-Derived Regulatory Dendritic Cells
L. M. Tran¹, T. Tabib², A. F. Zahorchak¹, R. Lafyatis², M. A. Styn¹, A. Humar¹, F. G. Lakkis¹, D. M. Metes¹, A. W. Thomson¹
¹Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Department of Medicine and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Single-cell RNA sequencing is an emerging, powerful genomic technology that can describe heterogenous cellular populations of whole solid organs with high resolution. We report…
2020 American Transplant Congress
Pregnancy Alloimmunization Increases the Clonality of the Endogenous Treg Repertoire
K. Krupp, E. Lewis, R. Xu, P. Porrett
University of Pennsylvania, Philadelphia, PA
*Purpose: Pregnancy is a common immune sensitizing event, which creates an access barrier to organ transplantation and can impact transplant outcomes. While most research has…
2020 American Transplant Congress
Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation
J. D. Fisher¹, W. Zhang², S. C. Balmert³, A. M. Aral¹, Y. Kulahci⁴, A. P. Acharya⁴, J. Li², H. R. Turnquist⁵, A. W. Thomson⁵, M. G. Solari², V. S. Gorantla⁶, S. R. Little⁴
¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, ²Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, ³Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, ⁵Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Bioengineering, Wake Forest University, Winston-Salem, NC
*Purpose: Vascularized composite allotransplantation (VCA) encompasses face and limb transplantation, but as with organ transplantation, it requires lifelong regimens of immunosuppressive drugs to prevent rejection.*Methods:…