Articles tagged "Tolerance"

2020 American Transplant Congress
Costimulatory Signal Impacts Car Treg Fate and Function in Transplantation
B. Lamarthée¹, A. Marchal¹, S. Charbonnier¹, T. Blein¹, K. Vogt², M. Titeux¹, N. Pallet³, M. Delville¹, E. Six¹, D. Anglicheau⁴, C. Legendre⁴, B. Sawitzki², J. Taupin⁵, M. Cavazzana¹, I. André¹, J. Zuber¹
¹Inserm U1163, Institut Imagine, Paris, France, ²Department of Immunology, Charité University Hospital, Berlin, Germany, ³Inserm U1147, Centre Universitaire des Saints Pères, Paris, France, ⁴Service de Transplantation Rénale Adulte, Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Paris, France, ⁵Inserm U1160, Centre Hayem, Paris, France
*Purpose: Donor-specific regulatory T-cell (Treg) therapy has emerged as a potent strategy to promote immune tolerance in experimental transplantation. However, a major stumbling block in…
2020 American Transplant Congress
Transplant Relevant MDSC Genetics: Differential Gene Expression Profiles of Immunosuppressive Myeloid-Derived Suppressor Cells Induced by Granulocyte-Colony Stimulating Factor
Y. S. Lee, J. S. Bromberg, J. R. Scalea
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are expanded in inflammation conditions and can control alloreactive T cell responses. Granulocyte-colony stimulating factor (GCSF) is known to induce…
2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Y. Itabashi, R. Ravichandran, S. Bansal, T. Fleming, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…
2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
P. M. Patel¹, B. A. Gonzalez Nolasco¹, J. A. Morrissette¹, A. Prunevieille¹, K. J. Ahrens¹, J. M. O¹, D. C. Becerra¹, G. Benichou¹, J. C. Madsen²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
2020 American Transplant Congress
Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Bruestle¹, F. Fredriksson¹, J. Stern¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…
2020 American Transplant Congress
IL-21, a Potential Target of Active Rejection in Renal Transplantation
J. Shen, R. Wang, L. Guo, J. Lv, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Rejection remains an obstacle to overcome after transplantation. IL-21 is the most potent stimulators of driving GC B cells into plasma cells. Basic researches…
2020 American Transplant Congress
TGF-b Induced Myeloid-Derived Suppressor Cells Prevent Transplatation Rejection by Promoting Immune Tolerance
P. Cao, Z. Sun, J. Zhang, F. Zhang, W. Wang
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a class of heterogeneous myeloid cells with immunosuppressive function. An effective method to produce MDSCs with better capacity and…
2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
2020 American Transplant Congress
Plasma Microbiome Profiles of Liver Transplant Patients with Operational Tolerance
C. Kuscu¹, J. Pierre², I. Lies¹, C. Kuscu¹, A. Bajwa¹, A. Wolen¹, J. Eason¹, B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹James D. Eason Transplant Institute, Department of Surgery, UTHSC, Memphis, TN, ²Department of Pediatrics, UTHSC, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, UPMC, Pittsburgh, PA
*Purpose: Microbiome has emerged as a key modulator of organ homeostasis and immune system function with altered microbiota and microbiome - host interactions contributing to…
2020 American Transplant Congress
Prognostic Value of Dd-cfDNA Assay in Acute Renal Rejection Therapy: A Prospective Cohort Study
L. Guo, R. Wang, J. Lv, J. Shen, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Donor-derived cell free DNA (dd-cfDNA) is a promising biomarker for monitoring allograft status. However, whether it is capable of reflecting real time anti-rejection treatment…