ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tissue-specific"

  • 2020 American Transplant Congress

    Allotransplantation of Ligated Arteriovenous Fistula as a Novel Strategy for Patients with Multiple Vascular Access Failures

    M. A. Jaramillo-Gante1, C. E. Acosta-Hernandez1, P. R. Castro-Casillas1, I. J. Linares-Cervantes2

    1Surgery, Star Medica Hospital, San Luis Potosi, Mexico, 2Surgery, University of Cincinnati Medical Center, Cincinnati, OH

    *Purpose: To evaluate the feasibility of allotransplantation of a ligated arteriovenous fistula*Methods: We report the first case of allotransplantation of a mature working arterialized cephalic…
  • 2020 American Transplant Congress

    Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection

    J. Habib, D. Mathews, Y. Dong, A. Stephenson, A. Adams

    Emory University, Atlanta, GA

    *Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…
  • 2019 American Transplant Congress

    Systematic Testing and Specificity Mapping of Alloantigen-Specific Chimeric Antigen Receptors in T Regulatory Cells

    C. Lamarche, N. Dawson, P. Bergqvist, R. Hoeppli, M. Mojibian, V. Feung, Q. Huang, J. Gillies, P. Orban, M. Levings

    University of British Columbia, Vancouver, BC, Canada

    *Purpose: Achieving transplant tolerance with regulatory T cell (Treg) adoptive immunotherapy is currently under investigation as a therapy to reduce graft rejection and improve long-term…
  • 2019 American Transplant Congress

    Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells

    C. Yang1, J. Ge1, P. S. Russell1, J. C. Madsen1, A. Alessandrini1, R. B. Colvin2

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Pathology, Massachusetts General Hospital, Boston, MA

    *Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…
  • 2019 American Transplant Congress

    Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation

    F. Wandrer1, B. Wiegmann2, N. Ledwoch1, R. Bellmas Sanz1, F. Ius2, W. Sommer2, S. Rojas2, C. Kühn2, I. Tudorache2, M. Avsar2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany

    *Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
  • 2018 American Transplant Congress

    Human Pancreatic ECM Scaffolds for Islet Culture and Transplantation

    D. Tremmel, S. Sackett, A. Feeney, R. Maguire, J. Odorico.

    Univ of Wisconsin, Madison.

    Extracellular matrix (ECM) plays an important role through structural and biochemical interaction with cells. Tissue-specific ECM, attained through decellularization (decel), has been proposed in many…
  • 2018 American Transplant Congress

    Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model

    S. Tullius,1 Y. Kumamoto,2 U. Nalan.3

    1Department of Medicine, Brigham and Women's Hospital, Boston, MA; 2Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; 3Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.

    Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…
  • 2018 American Transplant Congress

    Rapamycin Therapy Impairs Treg Expression of CXCR3 and Limits Treg-Dependent Survival of Vascularized Composite Allotransplants

    H. Xu,1 Z. Chen,2 W. Hancock,3,4 S. Levin,5 Y. Zhang.1

    1Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Medicine School of Shanghai Jiaotong University, Shanghai, China; 2Institute of Immunology, University of Pennsylvania, Philadelphia; 3Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; 4Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; 5Orthopaedic Surgery and Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia.

    Vascularized Composite Allotransplantation (VCA) is a procedure to restore limb function or facial appearance. Rapamycin is used in efforts to preserve host Treg function and…
  • 2017 American Transplant Congress

    Emerging Application of Active Immune Targeted Delivery in Transplantation.

    M. Uehara,1 J. Azzi,1 B. Bahmani,1,2 J. Cheng,3 Q. Yin,3 L. Tang,3 K. Cai,3 Q. Sun,3 M. Kwon,3 Q. Xu,2 G. Brandacher,4 R. Abdi.1

    1Transplantation Research Center/Renal Devision, Brigham and Women's Hospital, Boston; 2Department of Biomedical Engineering, Tufts University, Boston; 3Department of Materials Science and Engineering, University of Illinois at Urbana Champaingn, IL; 4Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore

    The homing of naïve lymphocytes to the lymph node (LN) is fundamental to the priming of alloreactive T cells. LNs possess highly restricted high endothelial…
  • 2017 American Transplant Congress

    Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.

    B. Kern,1 K. Sarhane,2 Z. Ibrahim,2 B. Mukherjee-Clavin,3 J. Budihardjo,2 C. Cashman,3 K. Krick,4 S. Schneeberger,1 W. Lee,2 H.-Q. Mao,4 G. Lee,3 G. Brandacher.2

    1Operative Medicine, Innsbruck Medical University, Innsbruck, Austria; 2Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 3Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; 4Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD

    Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…
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