Articles tagged "Tissue-specific"

2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
M. Ni¹, J. Zhang¹, R. Sosa², S. Kageyama¹, R. Busuttil¹, R. Elaine², J. Kupiec-Weglinski¹, X. Wang³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, ³Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
2020 American Transplant Congress
In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury
C. S. OBrien¹, P. T. Hernandez¹, S. J. Concors¹, L. N. Krumeich¹, Z. Wang¹, G. Ge¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA, ²Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, ³Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL
*Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
2020 American Transplant Congress
Generation and Long-Term Culturing of AIPCs for Islet Replacement
J. B. Pollett¹, R. Bottino², S. Bertera², M. Trucco², N. Thai²
¹Imagine Pharma, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
*Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…
2020 American Transplant Congress
Allotransplantation of Ligated Arteriovenous Fistula as a Novel Strategy for Patients with Multiple Vascular Access Failures
M. A. Jaramillo-Gante¹, C. E. Acosta-Hernandez¹, P. R. Castro-Casillas¹, I. J. Linares-Cervantes²
¹Surgery, Star Medica Hospital, San Luis Potosi, Mexico, ²Surgery, University of Cincinnati Medical Center, Cincinnati, OH
*Purpose: To evaluate the feasibility of allotransplantation of a ligated arteriovenous fistula*Methods: We report the first case of allotransplantation of a mature working arterialized cephalic…
2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
J. Habib, D. Mathews, Y. Dong, A. Stephenson, A. Adams
Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…
2020 American Transplant Congress
Gut-Restricted Microbiota Can Affect Outcome of Distal Skin Grafts
M. Sepulveda¹, L. Chen¹, Y. Wang¹, J. Park¹, Z. Early¹, B. Jabri², A. Chong³, M. Alegre¹
¹Medicine, University of Chicago, Chicago, IL, ²Pathology, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The communities of microorganisms that colonize barrier surfaces, termed the microbiota, are environmental agents that can influence the maturation and function of the immune…
2020 American Transplant Congress
The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor C-MET Signaling
L. Paka, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: Hepatocyte growth factor (HGF) regulates cell growth, development and tissue repair. HGF activity is mediated by the c-MET signaling pathway. The biological effects of…
2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
2019 American Transplant Congress
Systematic Testing and Specificity Mapping of Alloantigen-Specific Chimeric Antigen Receptors in T Regulatory Cells
C. Lamarche, N. Dawson, P. Bergqvist, R. Hoeppli, M. Mojibian, V. Feung, Q. Huang, J. Gillies, P. Orban, M. Levings
University of British Columbia, Vancouver, BC, Canada
*Purpose: Achieving transplant tolerance with regulatory T cell (Treg) adoptive immunotherapy is currently under investigation as a therapy to reduce graft rejection and improve long-term…
2019 American Transplant Congress
Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells
C. Yang¹, J. Ge¹, P. S. Russell¹, J. C. Madsen¹, A. Alessandrini¹, R. B. Colvin²
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…