Articles tagged "Tissue-specific"

2018 American Transplant Congress
Human Pancreatic ECM Scaffolds for Islet Culture and Transplantation
D. Tremmel, S. Sackett, A. Feeney, R. Maguire, J. Odorico.
Univ of Wisconsin, Madison.
Extracellular matrix (ECM) plays an important role through structural and biochemical interaction with cells. Tissue-specific ECM, attained through decellularization (decel), has been proposed in many…
2018 American Transplant Congress
Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model
S. Tullius,¹ Y. Kumamoto,² U. Nalan.³
¹Department of Medicine, Brigham and Women's Hospital, Boston, MA; ²Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; ³Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.
Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…
2018 American Transplant Congress
Rapamycin Therapy Impairs Treg Expression of CXCR3 and Limits Treg-Dependent Survival of Vascularized Composite Allotransplants
H. Xu,¹ Z. Chen,² W. Hancock,^3,4 S. Levin,⁵ Y. Zhang.¹
¹Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Medicine School of Shanghai Jiaotong University, Shanghai, China; ²Institute of Immunology, University of Pennsylvania, Philadelphia; ³Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; ⁵Orthopaedic Surgery and Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia.
Vascularized Composite Allotransplantation (VCA) is a procedure to restore limb function or facial appearance. Rapamycin is used in efforts to preserve host Treg function and…
2017 American Transplant Congress
Emerging Application of Active Immune Targeted Delivery in Transplantation.
M. Uehara,¹ J. Azzi,¹ B. Bahmani,^1,2 J. Cheng,³ Q. Yin,³ L. Tang,³ K. Cai,³ Q. Sun,³ M. Kwon,³ Q. Xu,² G. Brandacher,⁴ R. Abdi.¹
¹Transplantation Research Center/Renal Devision, Brigham and Women's Hospital, Boston; ²Department of Biomedical Engineering, Tufts University, Boston; ³Department of Materials Science and Engineering, University of Illinois at Urbana Champaingn, IL; ⁴Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore
The homing of naïve lymphocytes to the lymph node (LN) is fundamental to the priming of alloreactive T cells. LNs possess highly restricted high endothelial…
2017 American Transplant Congress
Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.
B. Kern,¹ K. Sarhane,² Z. Ibrahim,² B. Mukherjee-Clavin,³ J. Budihardjo,² C. Cashman,³ K. Krick,⁴ S. Schneeberger,¹ W. Lee,² H.-Q. Mao,⁴ G. Lee,³ G. Brandacher.²
¹Operative Medicine, Innsbruck Medical University, Innsbruck, Austria; ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ³Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…
2016 American Transplant Congress
Histone Deacetylase-2 Gene Deletion in Mice Mitigates Liver Ischemia/Reperfusion Injury.
D. Murken,¹ D. Aufhauser Jr,¹ Z. Wang,² G. Ge,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2016 American Transplant Congress
Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.
L. Wang, Z. Wang, R. Han, T. Bhatti, L. Levin, M. Levine, W. Hancock.
CHOP & UPenn, Philadelphia.
Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…
2015 American Transplant Congress
Rat Forelimb Allotransplantation: A Novel Microsurgical Model for Optimized Functional Assessment After Reconstructive Transplantation
B. Kern,¹ S. Tuffaha,¹ M. Khusheim,¹ S. Xiang,¹ G. Furtmueller,¹ K. Sarhane,¹ J. Park,² A. Hoke,² W. Lee,¹ G. Brandacher.¹
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Neurology and NeuroSurgery, Johns Hopkins University, Baltimore, MD.
Background:Functional outcomes following vascularized composite allotransplantation (VCA) have been promising, but there is still room for improvement. Studies to investigate strategies to overcome this obstacle…
2015 American Transplant Congress
Immune Response to Kidney and Pancreas Self-Antigens Are Associated With Antibody Mediated Rejection in Simultaneous Kidney Pancreas Transplants
M. Gunasekaran,¹ A. Siddiq,² S. Shenoy,¹ J. Wellen,¹ T. Mohanakumar.¹
¹Surgery, Washington Univ Sch of Med, St. Louis, MO; ²Medicine, Washington Univ Sch of Med, St. Louis, MO.
Background: Simultaneous kidney-pancreas transplantation (SKP Tx) is performed as treatment option for type-1 diabetes with end stage kidney diseases. Though allograft survival was improved with…
2015 American Transplant Congress
Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation
M. Gunasekaran,¹ T. Maw,³ R. Santos,³ J. Wellen,¹ S. Shenoy,¹ T. Mohanakumar.^1,2
¹Surgery, Washington Univ Sch of Med, St. Louis, MO; ²Pathology & Immunology, Washington Univ Sch of Med, St. Louis, MO; ³Medicine, Washington Univ Sch of Med, St. Louis, MO.
Background: Immune responses to tissue restricted self antigens have been proposed to play a role in transplant glomerulopathy (TG). The goal of this study is…