Articles tagged "Tissue-specific"

2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
2019 American Transplant Congress
Systematic Testing and Specificity Mapping of Alloantigen-Specific Chimeric Antigen Receptors in T Regulatory Cells
C. Lamarche, N. Dawson, P. Bergqvist, R. Hoeppli, M. Mojibian, V. Feung, Q. Huang, J. Gillies, P. Orban, M. Levings
University of British Columbia, Vancouver, BC, Canada
*Purpose: Achieving transplant tolerance with regulatory T cell (Treg) adoptive immunotherapy is currently under investigation as a therapy to reduce graft rejection and improve long-term…
2019 American Transplant Congress
Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells
C. Yang¹, J. Ge¹, P. S. Russell¹, J. C. Madsen¹, A. Alessandrini¹, R. B. Colvin²
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…
2018 American Transplant Congress
Human Pancreatic ECM Scaffolds for Islet Culture and Transplantation
D. Tremmel, S. Sackett, A. Feeney, R. Maguire, J. Odorico.
Univ of Wisconsin, Madison.
Extracellular matrix (ECM) plays an important role through structural and biochemical interaction with cells. Tissue-specific ECM, attained through decellularization (decel), has been proposed in many…
2018 American Transplant Congress
Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model
S. Tullius,¹ Y. Kumamoto,² U. Nalan.³
¹Department of Medicine, Brigham and Women's Hospital, Boston, MA; ²Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; ³Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.
Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…
2018 American Transplant Congress
Rapamycin Therapy Impairs Treg Expression of CXCR3 and Limits Treg-Dependent Survival of Vascularized Composite Allotransplants
H. Xu,¹ Z. Chen,² W. Hancock,^3,4 S. Levin,⁵ Y. Zhang.¹
¹Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Medicine School of Shanghai Jiaotong University, Shanghai, China; ²Institute of Immunology, University of Pennsylvania, Philadelphia; ³Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; ⁵Orthopaedic Surgery and Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia.
Vascularized Composite Allotransplantation (VCA) is a procedure to restore limb function or facial appearance. Rapamycin is used in efforts to preserve host Treg function and…
2017 American Transplant Congress
Emerging Application of Active Immune Targeted Delivery in Transplantation.
M. Uehara,¹ J. Azzi,¹ B. Bahmani,^1,2 J. Cheng,³ Q. Yin,³ L. Tang,³ K. Cai,³ Q. Sun,³ M. Kwon,³ Q. Xu,² G. Brandacher,⁴ R. Abdi.¹
¹Transplantation Research Center/Renal Devision, Brigham and Women's Hospital, Boston; ²Department of Biomedical Engineering, Tufts University, Boston; ³Department of Materials Science and Engineering, University of Illinois at Urbana Champaingn, IL; ⁴Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore
The homing of naïve lymphocytes to the lymph node (LN) is fundamental to the priming of alloreactive T cells. LNs possess highly restricted high endothelial…
2017 American Transplant Congress
Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.
B. Kern,¹ K. Sarhane,² Z. Ibrahim,² B. Mukherjee-Clavin,³ J. Budihardjo,² C. Cashman,³ K. Krick,⁴ S. Schneeberger,¹ W. Lee,² H.-Q. Mao,⁴ G. Lee,³ G. Brandacher.²
¹Operative Medicine, Innsbruck Medical University, Innsbruck, Austria; ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ³Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…
2016 American Transplant Congress
Histone Deacetylase-2 Gene Deletion in Mice Mitigates Liver Ischemia/Reperfusion Injury.
D. Murken,¹ D. Aufhauser Jr,¹ Z. Wang,² G. Ge,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2016 American Transplant Congress
Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.
L. Wang, Z. Wang, R. Han, T. Bhatti, L. Levin, M. Levine, W. Hancock.
CHOP & UPenn, Philadelphia.
Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…