2022 American Transplant Congress
Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis
*Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…2022 American Transplant Congress
Murine Intrahepatic Regulatory T Cells (TREGS) Modulate Acute Liver Inflammation by Promoting a Protective and Restorative Microenvironment
*Purpose: CD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and develop cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is…2022 American Transplant Congress
Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells
1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom
*Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…2021 American Transplant Congress
Donor T and NK Cells with a Special Tissue-Resident Memory Phenotype Migrate Into the Periphery of Lung Transplant Recipients – A Potential Feature for Tolerance Development
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…2021 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Renal Ischemia Reperfusion Injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. Previously, we have shown lower rates of…2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…2020 American Transplant Congress
In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury
*Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…2020 American Transplant Congress
Generation and Long-Term Culturing of AIPCs for Islet Replacement
1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA
*Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…2020 American Transplant Congress
Allotransplantation of Ligated Arteriovenous Fistula as a Novel Strategy for Patients with Multiple Vascular Access Failures
*Purpose: To evaluate the feasibility of allotransplantation of a ligated arteriovenous fistula*Methods: We report the first case of allotransplantation of a mature working arterialized cephalic…2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…
American Transplant Congress abstracts