Articles tagged "Tissue-specific"

2022 American Transplant Congress
Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis
T. Shi¹, A. Burg¹, K. Roskin², J. Rush³, B. Haraldsson³, A. Shields⁴, R. Alloway⁴, E. Woodle⁵, D. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Novartis Pharmaceuticals AG, Basel, Switzerland, ⁴Internal Medicine, University of Cincinnati, Cincinnati, OH, ⁵Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…
2022 American Transplant Congress
Murine Intrahepatic Regulatory T Cells (TREGS) Modulate Acute Liver Inflammation by Promoting a Protective and Restorative Microenvironment
A. S. Kurt¹, K. Strobl², P. Ruiz¹, A. Sanchez-Fueyo¹, M. Martinez-Llordella¹
¹Inflammation Biology, King's College London, London, United Kingdom, ²Institute of Cancer Research, Medical University of Vienna, London, United Kingdom
*Purpose: CD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and develop cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is…
2022 American Transplant Congress
Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells
E. Landmann¹, P. Ruiz¹, A. Kurt¹, E. Kodela¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…
2021 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner
C. S. O'Brien, P. Hernandez, Z. Wang, G. Ge, W. Hancock, M. H. Levine
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Renal Ischemia Reperfusion Injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. Previously, we have shown lower rates of…
2021 American Transplant Congress
Donor T and NK Cells with a Special Tissue-Resident Memory Phenotype Migrate Into the Periphery of Lung Transplant Recipients – A Potential Feature for Tolerance Development
L. M. Ruhl¹, R. Bellmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. A. Bläsing¹, W. Sommer², F. Ius², J. F. Kühne¹, A. Knöfel², L. M. Horn¹, I. Tudorache², A. Haverich², D. Jonigk³, G. Warnecke², C. S. Falk¹
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany, ³MHH, Institute of Pathology, Hannover, Germany
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
J. Habib, D. Mathews, Y. Dong, A. Stephenson, A. Adams
Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…
2020 American Transplant Congress
Gut-Restricted Microbiota Can Affect Outcome of Distal Skin Grafts
M. Sepulveda¹, L. Chen¹, Y. Wang¹, J. Park¹, Z. Early¹, B. Jabri², A. Chong³, M. Alegre¹
¹Medicine, University of Chicago, Chicago, IL, ²Pathology, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The communities of microorganisms that colonize barrier surfaces, termed the microbiota, are environmental agents that can influence the maturation and function of the immune…
2020 American Transplant Congress
The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor C-MET Signaling
L. Paka, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: Hepatocyte growth factor (HGF) regulates cell growth, development and tissue repair. HGF activity is mediated by the c-MET signaling pathway. The biological effects of…
2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
M. Ni¹, J. Zhang¹, R. Sosa², S. Kageyama¹, R. Busuttil¹, R. Elaine², J. Kupiec-Weglinski¹, X. Wang³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, ³Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
2020 American Transplant Congress
In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury
C. S. OBrien¹, P. T. Hernandez¹, S. J. Concors¹, L. N. Krumeich¹, Z. Wang¹, G. Ge¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA, ²Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, ³Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL
*Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…