ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tissue-specific"

  • 2022 American Transplant Congress

    Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis

    T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

    1Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Novartis Pharmaceuticals AG, Basel, Switzerland, 4Internal Medicine, University of Cincinnati, Cincinnati, OH, 5Surgery, University of Cincinnati, Cincinnati, OH

    *Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…
  • 2022 American Transplant Congress

    Murine Intrahepatic Regulatory T Cells (TREGS) Modulate Acute Liver Inflammation by Promoting a Protective and Restorative Microenvironment

    A. S. Kurt1, K. Strobl2, P. Ruiz1, A. Sanchez-Fueyo1, M. Martinez-Llordella1

    1Inflammation Biology, King's College London, London, United Kingdom, 2Institute of Cancer Research, Medical University of Vienna, London, United Kingdom

    *Purpose: CD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and develop cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is…
  • 2022 American Transplant Congress

    Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells

    E. Landmann1, P. Ruiz1, A. Kurt1, E. Kodela1, M. Martinez-Llordella2, A. Sanchez-Fueyo1

    1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom

    *Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…
  • 2021 American Transplant Congress

    Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner

    C. S. O'Brien, P. Hernandez, Z. Wang, G. Ge, W. Hancock, M. H. Levine

    Surgery, University of Pennsylvania, Philadelphia, PA

    *Purpose: Renal Ischemia Reperfusion Injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. Previously, we have shown lower rates of…
  • 2021 American Transplant Congress

    Donor T and NK Cells with a Special Tissue-Resident Memory Phenotype Migrate Into the Periphery of Lung Transplant Recipients – A Potential Feature for Tolerance Development

    L. M. Ruhl1, R. Bellmàs Sanz1, A. Hitz1, B. Wiegmann2, K. A. Bläsing1, W. Sommer2, F. Ius2, J. F. Kühne1, A. Knöfel2, L. M. Horn1, I. Tudorache2, A. Haverich2, D. Jonigk3, G. Warnecke2, C. S. Falk1

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany, 3MHH, Institute of Pathology, Hannover, Germany

    *Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
  • 2020 American Transplant Congress

    Gut-Restricted Microbiota Can Affect Outcome of Distal Skin Grafts

    M. Sepulveda1, L. Chen1, Y. Wang1, J. Park1, Z. Early1, B. Jabri2, A. Chong3, M. Alegre1

    1Medicine, University of Chicago, Chicago, IL, 2Pathology, University of Chicago, Chicago, IL, 3Surgery, University of Chicago, Chicago, IL

    *Purpose: The communities of microorganisms that colonize barrier surfaces, termed the microbiota, are environmental agents that can influence the maturation and function of the immune…
  • 2020 American Transplant Congress

    The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor C-MET Signaling

    L. Paka, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: Hepatocyte growth factor (HGF) regulates cell growth, development and tissue repair. HGF activity is mediated by the c-MET signaling pathway. The biological effects of…
  • 2020 American Transplant Congress

    TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury

    M. Ni1, J. Zhang1, R. Sosa2, S. Kageyama1, R. Busuttil1, R. Elaine2, J. Kupiec-Weglinski1, X. Wang3, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, 3Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
  • 2020 American Transplant Congress

    In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury

    C. S. OBrien1, P. T. Hernandez1, S. J. Concors1, L. N. Krumeich1, Z. Wang1, G. Ge1, T. Bhatti2, A. Kozikowski3, W. Hancock2, M. H. Levine1

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA, 2Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, 3Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL

    *Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
  • 2020 American Transplant Congress

    Generation and Long-Term Culturing of AIPCs for Islet Replacement

    J. B. Pollett1, R. Bottino2, S. Bertera2, M. Trucco2, N. Thai2

    1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA

    *Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…
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