2020 American Transplant Congress
Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies
*Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…2020 American Transplant Congress
HELLP Me! My Liver Ruptured and Nobody Can Give Me Platelets: A Case Study of Liver Transplantation for Liver Rupture from HELLP Syndrome
UCHealth University of Colorado Hospital, Aurora, CO
*Purpose: Liver rupture and infarction are rare but serious complications of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. We report successful utilization…2020 American Transplant Congress
Ehrlichiosis Infection Presenting as Thrombotic Microangiopathy Early after Kidney Transplantation
*Purpose: Fever of unknown origin and clinical picture of Thrombotic MicroAngiopathy (TMA) are diagnostic challenges in the early period after kidney transplantation. Here we present…2019 American Transplant Congress
Human Leukocyte Antigen Class I (HLA-I) Antibodies in Patients Undergoing Liver Transplantation: Implications for Platelet Transfusion Support
*Purpose: Liver transplantation is a high platelet transfusion (PLT) setting due to the elevated incidence of thrombocytopenia and bleeding. HLA-I antibodies are thought to have…2019 American Transplant Congress
Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation
1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Inc., Blacksburg, VA
*Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…2018 American Transplant Congress
hEPCR.hTBM.hCD47.HO-1 Contributes to Increased Survival, Reduced Platelet Sequestration, and Modulation of Coagulation Activation in GalTKO.hCD46 Porcine Livers Perfused with Human Blood
1University of Maryland School of Medicine, Baltimore, MD; 2Revivicor, Inc., Baltimore, MD.
IntroductionPlatelet sequestration and inappropriate coagulation cascade activation are associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate a cassette of additional genetic…2018 American Transplant Congress
Haematological Autoimmune Disorders Associated with Alemtuzumab Induction in Renal and Simultaneous Pancreas and Kidney Recipients
Introduction Haematological Autoimmune Disorders (HAD) have been associated with Alemtuzumab (Az); namely immune thrombocytopenia (ITP), autoimmune haemolytic anaemia (AIHA), Evans syndrome (ES) and Red Cell…2018 American Transplant Congress
Platelet Counts as Predictors of Short- and Long-Term Outcomes in Liver Transplantation: Cassandras or Just Rats on a Sinking Ship?
BackgroundThrombocytopenia is associated with higher morbidity and mortality following partial hepatectomy and orthotopic liver transplantation (OLT). Here we investigated platelet counts (PC) as a predictor…2018 American Transplant Congress
Genetic Risk Factors of Post-Transplant Thrombocytopenia in Kidney Allograft Recipients
Background: Posttransplant thrombocytopenia is prevalent after renal transplantation, which is associated with increased risk of bleeding and other complications. The CXC motif chemokine 12 (CXCL12)…2018 American Transplant Congress
Further In Vivo and In Vitro Evidence That Anti-CD40 MABS Do Not Induce Thromboembolism
Novartis Institutes for Biomedical Research, Basel, Switzerland.
Clinical trials with non-silenced anti-CD40L (anti-CD154) monoclonal antibodies (mAb) in patients with systemic lupus erythematosus (SLE) and idiopathic thrombocytopenic purpura (ITP) were halted after unexpected…
American Transplant Congress abstracts