Articles tagged "Thrombocytopenia"

2018 American Transplant Congress
hEPCR.hTBM.hCD47.HO-1 Contributes to Increased Survival, Reduced Platelet Sequestration, and Modulation of Coagulation Activation in GalTKO.hCD46 Porcine Livers Perfused with Human Blood
A. Cimeno,¹ L. Burdorf,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.¹
¹University of Maryland School of Medicine, Baltimore, MD; ²Revivicor, Inc., Baltimore, MD.
IntroductionPlatelet sequestration and inappropriate coagulation cascade activation are associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate a cassette of additional genetic…
2018 American Transplant Congress
Haematological Autoimmune Disorders Associated with Alemtuzumab Induction in Renal and Simultaneous Pancreas and Kidney Recipients
A. Kousios,¹ R. Charif,¹ M. Atta,² A. Luqmani,² N. Cooper,² D. Taube.¹
¹Renal and Transplant Centre, Imperial College NHS Trust, London, United Kingdom; ²Department of Haematology, Imperial College NHS Trust, London, United Kingdom.
Introduction Haematological Autoimmune Disorders (HAD) have been associated with Alemtuzumab (Az); namely immune thrombocytopenia (ITP), autoimmune haemolytic anaemia (AIHA), Evans syndrome (ES) and Red Cell…
2018 American Transplant Congress
Platelet Counts as Predictors of Short- and Long-Term Outcomes in Liver Transplantation: Cassandras or Just Rats on a Sinking Ship?
I. Amygdalos,¹ Z. Czigany,¹ J. Böcker,¹ F. Meister,¹ M. Krebbers,¹ D. Morales Santana,¹ J. Bednarsch,¹ W. Schöning,¹ F. Ulmer,¹ G. Koek,³ D. Kroy,² F. Tacke,² C. Trautwein,² U. Neumann,¹ G. Lurje.¹
¹Department of General, Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, Germany; ²Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany; ³Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
BackgroundThrombocytopenia is associated with higher morbidity and mortality following partial hepatectomy and orthotopic liver transplantation (OLT). Here we investigated platelet counts (PC) as a predictor…
2018 American Transplant Congress
Genetic Risk Factors of Post-Transplant Thrombocytopenia in Kidney Allograft Recipients
D. Min,¹ Y. Chang,² T. Shah.³
¹College of Pharmacy, Western University of Health Sciences, Pomoma, CA; ²National Institute of Transplantation Foundation, Los Angeles, CA; ³Multiorgan Transplantation Center, St. Vincent Medical Center, Los Angeles, CA.
Background: Posttransplant thrombocytopenia is prevalent after renal transplantation, which is associated with increased risk of bleeding and other complications. The CXC motif chemokine 12 (CXCL12)…
2018 American Transplant Congress
Further In Vivo and In Vitro Evidence That Anti-CD40 MABS Do Not Induce Thromboembolism
T. Rubic-Schneider, B. Christen, N. Runser Loll, D. Garcia, E. Erard, T. Flandre, B. Cochin de Billy, S. Nock, S. Côté, J. Rush, P. Ulrich.
Novartis Institutes for Biomedical Research, Basel, Switzerland.
Clinical trials with non-silenced anti-CD40L (anti-CD154) monoclonal antibodies (mAb) in patients with systemic lupus erythematosus (SLE) and idiopathic thrombocytopenic purpura (ITP) were halted after unexpected…
2017 American Transplant Congress
Simultaneous Pancreas-Kidney Transplantation Can Be Safely Done on Dabigatran Therapy.
W. Lisik,¹ A. Jozwik,¹ J. Czerwinski,² L. Gorski,¹ M. Kosieradzki.¹
¹Department of General and Transplantation Surgery, The Medical University of Warsaw, Warsaw, Poland; ²Department of Surgical and Transplant Nursing, The Medical University of Warsaw, Warsaw, Poland
Due to convenient application, novel oral anticoagulants (NOAC), although not registered for renal failure, are an attractive therapeutic option. They are even more tempting in…
2016 American Transplant Congress
Inclusion of Human Tissue Factor Pathway Inhibitor or Thrombomodulin Transgenes Attenuates Critical Consumptive Thrombocytopenia in Cardiac Xenotransplantation.
J. Chan,¹ A. Singh,¹ P. Corcoran,¹ M. Thomas III,² B. Lewis,² D. Ayares,³ K. Horvath,¹ M. Mohiuddin.¹
¹Cardiothoracic Surgery Research Program/National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; ²Division of Veterinary Resources, National Institutes of Health, Bethesda, MD; ³Revivicor Inc., Blacksburg, VA.
ObjectiveA major obstacle in the success of cardiac xenotransplantation has been the development of significant consumptive thrombocytopenia, frequently limiting recipient survival. Advances in genetic engineering…
2016 American Transplant Congress
An Improved Flow Cytometry Based Platelet Counting in Xeno Perfusion Models.
S. Sendil,¹ G. Braileanu,¹ W. Sun,¹ W. Hassanein,¹ D. Parsell,¹ H. Crum,² L. Burdorf,¹ R. Pierson,¹ A. Azimzadeh.¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; ²VA Medical Center, Baltimore, MD.
Aim: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion; its mechanism remains poorly understood. In the context of a regimen…
2015 American Transplant Congress
Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release
D. Zecher,^1,4 A. Cumpelik,¹ D. Tsakiris,² M. Dickenmann,³ J. Schifferli.¹
¹Department of Research, Basel University Hospital, Basel, Switzerland; ²Department of Hematology, Basel University Hospital, Basel, Switzerland; ³Department of Nephrology, Basel University Hospital, Basel, Switzerland; ⁴Department of Nephrology, Regensburg University Hospital, Regensburg, Germany.
T cell depletion with antithymocyte globulins (ATG) can be complicated by thrombopenia andhypercoagulability. The underlying mechanism is still unclear. We found that binding of ATG…