ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Thrombocytopenia"

  • 2022 American Transplant Congress

    Early Post-Operative Thrombotic Microangiopathy in Deceased Donor Kidney Transplant: A Retrospective Case Series

    R. Seneriz1, A. Mattiazzi1, G. Guerra1, T. Harrington2, M. Velasquez3

    1Miami Transplant Institute, Miami, FL, 2University of Miami, Miami, FL, 3Jackson Memorial Hospital, Miami, FL

    *Purpose: Transplant associated thrombotic microangiopathy (TA-TMA) is characterized by endothelial injury along with thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and kidney graft dysfunction. It can be…
  • 2021 American Transplant Congress

    Imaging Flow Cytometry Reveals That Platelet-Sized Erythrocyte Fragments are Formed During Pig Organ Perfusion with Human Blood

    Z. A. Habibabady1, F. Ellett2, L. Burdorf1, M. Connolly1, F. Pollok1, D. Irimia2, R. N. Pierson III1, A. M. Azimzadeh1

    1Center for Transplantation Sciences, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, 2Center for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA

    *Purpose: Severe thrombocytopenia frequently occurs after xenotransplantation of porcine cells or organs, and when pig organs are perfused with human blood. We developed a flow…
  • 2021 American Transplant Congress

    Delayed Valganciclovir Initiation and the Incidence of Cytomegalovirus Infection in Liver Transplant Recipients

    S. Shaikh, P. Kawewat-Ho, Y. Genyk, L. Sher, J. Kahn, L. Rivera

    Keck Medical Center of USC, Los Angeles, CA

    *Purpose: Opportunistic infections remain a significant burden after liver transplantation, particularly cytomegalovirus (CMV) infection. With the use of valganciclovir (VGCV), the incidence of CMV infection…
  • 2021 American Transplant Congress

    Rabbit Anti-thymocyte Globulin Induction Dosing Strategies in a High-risk Kidney Transplant Population

    C. Nguyen, R. Yau, C. Tunwar

    Pharmacy, CHI Baylor St. Luke's Medical Center, Houston, TX

    *Purpose: The objective of this retrospective observational study is to compare the safety and efficacy of two dosing strategies, rabbit anti-thymocyte globulin (rATG) at a…
  • 2021 American Transplant Congress

    Systematic Evaluation of Immunosuppressant Drug Tolerability in Lung Transplant Recipients with Short Telomere Syndrome

    R. Patolia1, R. Guzy2, L. Potter1

    1Department of Pharmacy, University of Chicago Medicine, Chicago, IL, 2Department of Medicine, Division of Pulmonology, University of Chicago Medicine, Chicago, IL

    *Purpose: Lung transplant recipients with short telomere syndrome are at high risk of hematologic complications. Consequently, patients with short telomere syndrome may require more frequent…
  • 2020 American Transplant Congress

    HELLP Me! My Liver Ruptured and Nobody Can Give Me Platelets: A Case Study of Liver Transplantation for Liver Rupture from HELLP Syndrome

    R. Cooke, M. Williams, M. A. Adams

    UCHealth University of Colorado Hospital, Aurora, CO

    *Purpose: Liver rupture and infarction are rare but serious complications of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. We report successful utilization…
  • 2020 American Transplant Congress

    Ehrlichiosis Infection Presenting as Thrombotic Microangiopathy Early after Kidney Transplantation

    W. Hassan1, M. Talwar2, V. Balaraman2, B. Wall1, M. Molnar1

    1Medicine-Nephrology, University of Tennessee Health Science Center, Memphis, TN, 2Department of Surgery, Transplant Surgery, Methodist University Hospital, James D Eason Transplant Institute, Memphis, TN

    *Purpose: Fever of unknown origin and clinical picture of Thrombotic MicroAngiopathy (TMA) are diagnostic challenges in the early period after kidney transplantation. Here we present…
  • 2020 American Transplant Congress

    Enumeration of Platelets by Flow Cytometry Reveals Human Erythrocyte Fragmentation During Pig Organ Xenoperfusion Studies

    Z. Abady1, K. M. Petitpas1, L. Burdorf1, S. G. Pratts1, B. M. Cerel1, S. Sendil2, M. R. Connolly1, W. Qin3, Y. Kan3, J. Layer3, M. Youd3, W. Westlin3, L. Yang3, R. N. Pierson III1, A. M. Azimzadeh1

    1Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, 2Surgery, University of Maryland School of Medicine, Baltimore, MD, 3eGenesis, Cambridge, MA

    *Purpose: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion, although the mechanism remains poorly understood. To evaluate an apparent “rebound”…
  • 2019 American Transplant Congress

    Human Leukocyte Antigen Class I (HLA-I) Antibodies in Patients Undergoing Liver Transplantation: Implications for Platelet Transfusion Support

    M. Wong1, R. Narra2, M. Selim1, M. A. Zimmerman1, A. Padmanabhan3, J. C. Hong1

    1Div. of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI, 2Div. of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, 3Medical College of Wisconsin and BloodCenter of Wisconsin, Milwaukee, WI

    *Purpose: Liver transplantation is a high platelet transfusion (PLT) setting due to the elevated incidence of thrombocytopenia and bleeding. HLA-I antibodies are thought to have…
  • 2019 American Transplant Congress

    Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation

    H. Iwase1, A. Jagdale1, T. Yamamoto1, G. Zhang1, Q. Li1, J. Foote1, D. Ayares2, H. Hara1, D. K. Cooper1

    1University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Inc., Blacksburg, VA

    *Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…
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