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Articles tagged "T helper cells"

  • 2015 American Transplant Congress

    Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells

    V. Gorbacheva, R. Fan, A. Valujskikh.

    Immunology, The Cleveland Clinic, Cleveland, OH.

    Immunosuppression-resistant alloreactive memory CD4 T cells induce robust responses against organ transplants. In murine heart allograft recipients donor-reactive memory CD4 T cells provide help for…
  • 2015 American Transplant Congress

    Mechanisms Underlying Treg Dysfunction in DAIH- Role for PD-L1?

    A. Arterbery,1 M. Martinez,2 S. Lobritto,2 Y. Avitzur,3 K. Raddassi,1 M. Kleinewietfeld,4 U. Ekong.1

    1Yale, NH; 2Columbia, NY; 3HSC, Toronto, Canada; 4Dresden University of Technology, Dresden, Germany.

    Background: we have previously shown that ex vivo Tregs from patients with DAIH demonstrate differentiation plasticity towards TH17. To understand the mechanisms underlying this we…
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