Articles tagged "T helper cells"

2020 American Transplant Congress
CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel
N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…
2020 American Transplant Congress
Targeting Th17: TIGIT as a Key Regulator of Tregs/Th17 Cells in Belatacept Resistant Rejection
C. R. Hartigan, M. Wagener, M. L. Ford
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept resistant-rejection (BRR) is a major barrier to the widespread adoption of immune checkpoint blockade therapeutics in transplantation. Our lab has shown that patients…
2019 American Transplant Congress
Circulating T Follicular Helper Proliferation And Memory B Cell Activation Correlate With Donor Specific Allo-antibody Occurrence And Antibody-mediated Rejection After Kidney Transplantation
K. Louis¹, C. Macedo¹, M. Marrari¹, B. Ramaswami¹, M. Lucas¹, B. Elinoff¹, M. Yamada¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm Unité mixte de recherche 1160, Paris, France
*Purpose: Crosstalk between T follicular helper (Tfh) cells and B cells is necessary for class-switched antibody generation. The contribution of memory Tfh and B cells…
2019 American Transplant Congress
Erythropoietin Ameliorates Parent to F1 Murine Graft versus Host Disease by Inhibiting T_FH
A. Angeletti¹, C. Donadei¹, A. Cumpelik¹, C. Cantarelli¹, C. Guglielmo¹, G. La Manna², P. Heeger¹, P. Cravedi¹
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (DIMES), Policlinico Sant'Orsola-Malpighi, Bologna, Italy
*Purpose: Building upon our previously generated evidence that erythropoietin (EPO) directly inhibits effector T cells (JASN 2015, 2017) and reduces autoantibody formation in murine lupus,…
2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…
2019 American Transplant Congress
The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?
L. Belyayev¹, M. Sadat², K. Loh³, S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. M. Fishbein², A. Kroemer²
¹Surgery, Walter Reed National Military Medical Center, Bethesda, MD, ²Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, ³Pediatrics, Children’s National Medical Center, Washington D.C., DC
*Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
2019 American Transplant Congress
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent
G. M. La Muraglia II, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Clinical costimulation blockade of the CD28 pathway in the form of CTLA-4Ig has shown the ability to attenuate T cell dependent DSA responses. However,…
2019 American Transplant Congress
Memory T Follicular Helper Cell Alloresponse is Memory B Cell Independent and Inhibited by CD28 Costimulation Blockade
S. Zeng, G. M. La Muraglia II, M. L. Ford, I. R. Badell
Emory University School of Medicine, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but reliable and durable therapeutic options to prevent or eliminate donor-specific antibodies (DSA)…
2019 American Transplant Congress
Early CXCR5⁺PD1⁺ICOS⁺Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation
R. Danger¹, M. Chesneau¹, F. Delbos², S. Lebot¹, C. Kerleau¹, A. Chenouard¹, A. Cesbron², M. Giral³, S. Brouard³
¹CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France, ²Laboratoire Histocompatibilité et Immunogénétique - Etablissement Français du sang, Nantes, France, ³Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques, Fondation Centaure, CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France
*Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…
2019 American Transplant Congress
Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics
J. Tchervenkov¹, M. Nguyen², S. Negi¹, S. Paraskevas¹
¹RIMUHC, Montreal, QC, Canada, ²SSM Health Saint Louis University Hospital, St. Louis, MO
*Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…