2022 American Transplant Congress
TEMRA CD8 T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2x4 Receptor-Dependent Proinflammatory and Migratory Responses
*Purpose: Whereas the role of effector memory and TEMRA CD8 in allotransplantation has been clearly evidenced and particularly the direct correlation between intragraft infiltrating CD8…2022 American Transplant Congress
CD8+ T Cells Differentiate into a CD43-expressing Effector Population After Transplantation
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: Despite a significantly reduced toxicity profile and improved long-term graft function versus calcineurin inhibitors, widespread adaptation of belatacept (CTLA-4 Ig) has been limited due…2022 American Transplant Congress
CD40 Expressed by FRC Regulates Lymph Node Structure and Function
*Purpose: Fibroblastic reticular cells (FRC) support lymph node (LN) structure and can regulate T cell function through the CD40-CD40L pathway. Our previous work showed that…2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…2022 American Transplant Congress
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance
Surgery, University of Wisconsin, Madison, WI
*Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…2022 American Transplant Congress
Synergistic Effect of CXCR5+CD8+ TAb-supp Cell Adoptive Cell Therapy and mTOR Inhibition (but Not Calcineurin Inhibition) in Suppressing Alloantibody Following Kidney Transplant in Mice
*Purpose: We have reported that CXCR5+CD8+TAb-supp cells mediate suppression of alloantibody (alloAb) production and prolong graft survival in both hepatocellular and kidney transplant (KTx) mouse…2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…2022 American Transplant Congress
Immune Checkpoints, Immune Cells, and MHC Expression in the Tumor Microenvironment of Resected Hepatocellular Carcinomas
*Purpose: Advances in tumor biology has shown the important role of the tumor microenvironment (TME) in tumor growth and metastasis. A better understanding of the…2022 American Transplant Congress
Treg Tissue Stability Depends on Adenosine Receptor Driven Lymphatic Endothelial Cell Responses
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Migrating Tregs were…2022 American Transplant Congress
Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation
*Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…
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