2015 American Transplant Congress
Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin
Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…2015 American Transplant Congress
Identification of CXCR5+EBV-Specific CD8+ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…2015 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy Targeting Ischemia/Reperfusion Injury in Heart Transplantation
1Immunology, Cleveland Clinic, Cleveland, OH; 2Aeromics, LLC, Cleveland, OH.
Aquaporin 4 (AQP4) belongs to the family of small integrin transmembrane proteins that are highly permeable to water. It was recently shown that human and…2015 American Transplant Congress
Feasibility of Regulatory T Cell Cryopreservation and Banking for Clinical Therapeutic Applications
Feasibility of clinical application of regulatory T cells (Tregs) in clinical transplantation would be improved if Tregs or pre-enriched cells for Treg isolation could be…2015 American Transplant Congress
Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch
Background. Contradictory observations have been published regarding the functionality of TEMRA CD8 T cells. TEMRA CD8 have been shown to accumulate with age or chronic…2015 American Transplant Congress
Boosting the Adaptive Immune Response Prevents the High Incidence of Herpes Zoster After Lung or Heart Transplantation
Purpose Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in ganglia from which it may reactivate leading to herpes zoster (HZ).…2015 American Transplant Congress
Rational Development of Alloantigen Specific Regulatory T Cell Therapy Requires Insight Into Longevity of Alloimmune Pathways
University of Cambridge, Cambridge, United Kingdom.
IntroductionWe have recently demonstrated that indirect-pathway responses against different alloantigens differ in their strength and longevity; specifically, that indirect responses against MHC class I alloantigen…2015 American Transplant Congress
Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function
Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…2015 American Transplant Congress
Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation
Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a co-receptor for a variety of ligand families including VEGF, EGF and semaphorins all of which are often produced by malignant…2015 American Transplant Congress
Increased Frequency of Terminally Differentiated and Exhausted CD8+ T Cells Is Associated With Adverse Clinical Outcome After Mechanical Circulatory Support Device Implantation
Clinical outcomes vary after mechanical circulatory support device (MCSD) implantation, with some patients developing multi organ system dysfunction (MOD), sometimes leading to death. We hypothesized…
American Transplant Congress abstracts