2016 American Transplant Congress
Assessing the Induction of Tolerance to Vascularized Composite Allotransplantation in Miniature Swine.
Plastic and Reconstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD.
Purpose: Miniature swine is a pre-clinical large animal model well suited to validate protocols of tolerance induction to vascularized composite allotransplantation (VCA). However, tools to…2016 American Transplant Congress
Direct Detection of T and B Memory Lymphocytes Reveals HCMV Exposure That Serum Antibodies Fail to Identify.
Research and Development, Cellular Technology Ltd, Shaker Hts, OH.
It is essential to identify donors who have not been infected with HCMV in order to avoid transmission of HCMV to human recipients of transfusion…2016 American Transplant Congress
Impact of Induction Therapy on Cardiovascular Events in Kidney Transplant Recipients.
1MUHC, Montreal, Canada; 2JHU, Baltimore.
Cardiovascular events (CVE) are one of leading causes of mortality in kidney transplant (KT) recipients and ATG use is reported as a risk factor. We…2016 American Transplant Congress
DEPTOR Inhibits mTORC1 in CD4+ T Cells and Increases Treg Function by Stabilizing Foxp3 Expression.
The modulation of PI-3K/Akt-induced signaling is critical for CD4+ Treg homeostasis and stability. Moreover, activation of PI-3K/Akt/mTOR signals within T cell subsets is associated with…2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
1CHOP & UPenn, Philadelphia, PA; 2Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…2016 American Transplant Congress
Clinical Outcome in Pure T-Cell Mediated Acute Rejection of the Kidney with No Donor Specific Antibody or C4d Staining.
Background: T-cell mediated rejection (TCMR) is now considered to have little impact on renal graft function. This study re-evaluated the histologic phenotypes and clinical significance…2016 American Transplant Congress
In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells – A Novel Approach for Tolerance Induction in Transplantation.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.
Background: Cell-based therapies represent a new promising approach for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…2016 American Transplant Congress
Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in De Novo Living Donor Kidney Transplant Recipients.
1Northwestern University, Chicago; 2NMH, Chicago; 3TRACT Therapeutics, Chicago.
Therapeutic cell transfer using regulatory T cells (Tregs) holds the promise of reducing the need for drug based immunosuppression (IS) and improving long term graft…2016 American Transplant Congress
Human and Mouse Treg Use Lymphotoxin for Migration Across Lymphatic Endothelium.
1University of Maryland, Baltimore, MD; 2Univerity of Minnesota, Minneapolis, MN.
Introduction: Lymphotoxin (LT) directs lymphoid organ structure, and LTβ receptor (LTβR) is involved in leukocyte migration into lymph nodes (LN) and thymocyte migration. We previously…2016 American Transplant Congress
Novel Function of CD4+ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…
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