Articles tagged "T cells"

2017 American Transplant Congress
CD4 and CD8 T Cells: Respectively Reprogrammed and Recapitulated in the Neonate to Induce Transplant Tolerance.
R. Bascom, K. Tao, L. West.
Alberta Transplant Institute, University of Alberta, Edmonton, Canada
Purpose: Non-conditioned neonatal mice develop acute graft-versus-host disease (aGVHD) when injected with adult allogeneic spleen and bone marrow cells (allo-SC/BMC). To prevent aGVHD and induce…
2017 American Transplant Congress
High CTLA-4 Expression and Diminished FOXO3 Expression Underlie Differential CD28 Signaling on Human Memory Th17 Cells.
S. Krummey,¹ S. Suchard,¹ S. Nadler,² C. Larsen,² M. Ford.¹
¹Emory Transplant Center, Emory University School of Medicine, Atlanta, GA; ²Bristol Meyers Squibb, Princeton, NJ
Pathogen primed memory T cells can cross-react with allogeneic antigen and mediate graft rejection, a process termed allogeneic heterologous immunity. Th17 cells are pro-inflammatory CD4+…
2017 American Transplant Congress
Myeloid-Derived Suppressor Cells (MDSC) Accumulate in Intestinal Transplant (IT) Recipients (rc) and Suppress Recipient T-Cell (T) Response Against Donor Antigen.
S. Okano,¹ D. Kish,² K. Keslar,² W. Baldwin,² R. Fairchild,¹ C. Miller,¹ K. Abu-Elmagd,¹ A. Khanna,¹ M. Fujiki,¹ J. Fung,¹ G. Costa,¹ K. Hashimoto.¹
¹Transplant Center, Dept. General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH; ²Dept. Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
[Introduction] Recent advances of immunosuppressive regimens have decreased rejection rate and improved rc survival of IT. MDSC are potent immature myeloid cells capable of suppressing…
2017 American Transplant Congress
Persistent Donor Antigen Leads to Dysfunctional CD4⁺Memory T Cell Development.
M. Miller,¹ Y. Wang,¹ L. Chen,¹ Y. Lei,¹ M. Daniels,^2,3 E. Watkins,⁴ C. Mora Solano,² C. McIntosh,¹ N. Isaad,⁵ A. Chong,² M.-L. Alegre.¹
¹Medicine, University of Chicago, Chicago, IL; ²Surgery, University of Chicago, Chicago, IL; ³Chicago State University, Chicago, IL; ⁴Institute for Molecular Engineering, University of Chicago, Chicago, IL; ⁵Committee on Cancer Biology, University of Chicago, Chicago, IL
Tolerance to alloantigens is characterized by low alloreactive T cell responses upon restimulation with donor antigens, a state that can result from deletion of donor-specific…
2017 American Transplant Congress
CTLA4-Ig in Combination with FTY720 Reduces the Frequency of Memory Alloreactive T Cells and Promotes Heart Allograft Survival in Sensitized Recipients.
S. Khiew,¹ J. Yang,¹ J. Young,¹ J. Chen,¹ Q. Wang,¹ D. Ying,¹ V. Vu,¹ M. Miller,² R. Sciammas,³ M.-L. Alegre,² A. Chong.¹
¹Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL; ²Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL; ³Center for Comparative Medicine, University of California, Davis, CA
Despite recent evidence of improved graft outcomes and safety, high incidence of early acute cellular rejection with belatacept has limited its use in clinical transplantation.…
2017 American Transplant Congress
TIM-3 – CEACAM1 Checkpoint Regulation of T-Cell Activation and Hepatocellular Function in Liver Transplantation.
K. Nakamura,¹ S. Kageyama,¹ M. Kujawski,³ R. Sosa,² E. Reed,² A. Zarrinpar,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Dept. Surgery, UCLA, Los Angeles, CA; ²Dept. Pathology, UCLA, Los Angeles, CA; ³Dept. Molecular Immunology, City of Hope, Duarte, CA
Background/Aim: We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CD66a; CM1; Carcinoembryonic Antigen-Related Cell Adhesion…
2017 American Transplant Congress
Early Results of Immune Profile Emerging Before Detection of De Novo Humoral Alloimmunity in Kidney Transplant Recipients.
J. Zimmerer, B. Ringwald, R. Pelletier, A. El-Hinnawi, A. Rajab, G. Bumgardner.
OSUMC, Columbus
The purpose of this IRB-approved study is to determine if there is a potential role for CD8+ T cell-mediated suppression of donor specific alloantibody (DSA)…
2017 American Transplant Congress
CD4 T Cells and Co-Engagement with Foreign Protein Are Required in Antibody Response to Non-Self Blood Group A-Antigen.
I. Adam, B. Motyka, L. West.
Micro & Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, Surgerey, and Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada
Background: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. B-cell tolerance develops to donor A/B-antigen(s) (Ag) after ABOi HTx…
2017 American Transplant Congress
Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival.
R. Deng, X. Lu, M. Chen, Z. Xue, X. Zhang, J. Xu, L. Wu, Y. Ma.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The capability of dendritic cells (DCs) to induce an immune response or immune tolerance is dependent on their status. Suppressor of cytokine signaling 1 (SOCS1)…
2017 American Transplant Congress
Tolerant Pediatric Liver Transplant (LT) Recipients (TOL) from WISP-R (NCT00320606) Split into Two Phenotypically Distinct Groups by PD1 Expression on CD4+ T Cells at Baseline, Prior to Immunosuppression Withdrawal (ISW).
B. Burrell,¹ S. Feng,² N. Bridges,³ U. Ekong,⁴ S. Kanaparthi,¹ A. Kirk,⁵ A. Long,¹ K. Spain,⁶ L. Stempora,⁵ L. Turka,¹ N. Tchao.¹
¹ITN, Bethesda; ²UCSF, San Francisco; ³NIAID, Bethesda; ⁴Yale, New Haven; ⁵Duke, Durham; ⁶Rho, Chapel Hill
Background: Combinations of cell surface markers such as PD1, CD57, and/or KLRG1 identify T cells that may fail to respond to cognate antigen challenge –…