2018 American Transplant Congress
Persistence and Homing of Autologous Donor-Reactive Ex-Vivo Expanded Regulatory T Cells to Heart Allografts in Lymphodepleted Recipient Monkeys
Surgery, Starzl Transplantation Institute, Pittsburgh, PA.
Background:Infusion of ex vivo expanded regulatory T cells (Treg) is a promising therapy to prevent allograft rejection. Trafficking of Treg to allografts and secondary (2ry)…2018 American Transplant Congress
CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…2018 American Transplant Congress
Detection of Different Gene Expression Profiles in CD8+ T Cells from Chronic High EBV Load Carriers after Pediatric Heart and Liver Transplantation
Background: EBV infection and post-transplant lymphoproliferative disorders (PTLD) are life-threatening complications of pediatric solid organ transplantation (Tx). The risk for PTLD varies by transplanted organ,…2018 American Transplant Congress
Patients Converted to Belatacept Show Different Immunophenotyping Compared with De Novo Belatacept-Treated Patients
The incidence of adverse clinical events mainly in early, but not late post-transplantation such as an increased rate of acute rejection precludes the use of…2018 American Transplant Congress
Melatonin Prolongs Heart Allograft Survival by Induction of Foxp3+ Regulatory T Cells
The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
Objective: This study was aimed to investigate the effect of melatonin on heart allograft survival and explore the underlying mechanism. Methods and Results: Balb/c and…2018 American Transplant Congress
A Natural Herb Danshen Suppresses Allospecific Memory CD8+ T Cell Generation and Murine Allograft Rejection
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Inducing long-term transplant survival or tolerance without continuous global immunosuppression is a highly desired goal in transplantation given that conventional immunosuppressive drugs may cause side…2018 American Transplant Congress
Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts
In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…2018 American Transplant Congress
Molecular Analysis of Acute Cellular Rejection in Clinical Face Transplants
Brigham and Women's Hospital, Boston.
Although monitoring and immunosuppression of vascularized composite allografts (VCA) draw experience from solid organ transplantation, VCAs pose unique challenges. A deeper understanding of mechanisms underlying…2018 American Transplant Congress
Assessment of Immune Cell Profiles in HLA-Sensitized (HS) & Non-HS Patients (Pts) with End Stage Renal Disease (ESRD)
Background: Chronic inflammation is often seen in pts w/ ESRD. HLA-sensitization may create or be driven by the cytokines responsible for chronic inflammation. Here we…2018 American Transplant Congress
Involvement of PD-L1 Upregulation in Anti-A/B Antibody-Induced Graft Accommodation: Reduction of CD4 T Cell Allo-Response against Graft HLA Class II DR
[Background] Antibodies against transplanted organs cause complement-independent graft injury, but there remain many unknown aspects of its mechanism, in particular its effect on allo-response to…
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