Articles tagged "T cells"

2018 American Transplant Congress
Emergence of a Costimulation-Susceptible T Cell Repertoire Post-Alemtuzumab Induction
Q. Gao,¹ A. Mehta,² A. Guasch,² L. Stempora,¹ A. Kirk,¹ H. Xu.¹
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.
Kidney transplant patients treated with belatacept-based regimens without depletional induction have higher rates of costimulation blockade resistant rejection (CoBRR). In contrast, belatacept effectively prevents rejection…
2018 American Transplant Congress
Vendor-Specific Differences in Identical Strains of Mice Yield Dichotomous Result in Lung Allograft Rejection
Y. Guo, Q. Wang, O. Onyema, A. Gelman, D. Kreisel, A. Krupnick.
Surgery, University of Virginina, Charlottesville, VA; Surgery, Washington University in St. Louis, St. Louis, MO.
Intro: Orthotropic transplantation of murine lung allografts has paved the way for mechanistic studies of pulmonary tolerance and rejection but discrepancies have been reported by…
2018 American Transplant Congress
Immunomonitoring of Operational Tolerance in Intestinal Transplantation
O. Aguirre, B. Houlihan, T. Fishbein, A. Kroemer.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
2018 American Transplant Congress
Central Role of Mef2 Transcription Factors in Regulation of Foxp3 Expression and Treg Function
A. Samanta,¹ L. Wang,¹ R. Han,¹ W. Hancock.^1,2
¹CHOP, Philadelphia; ²UPenn, Philadelphia.
Foxp3+ Tregs express 4 class IIa Hdac enzymes (Hdac4, 5, 7 & 9) with little or no catalytic activity and yet when deleted, at least…
2018 American Transplant Congress
Interferon-b Promotes Regulatory T Cell (Treg) Induction and Prolongs Allograft Survival
M. Fribourg,¹ M. McGinty,² A. Angeletti,² M. Demir,² S. Sealfon,¹ P. Heeger,² P. Cravedi.²
¹Neurology, Icahn School of Medicine at Mount Sinai, New York; ²Medicine, Translational Transplant Research Center, Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York.
Background: Interferon-b (IFNb), a type I interferon with antiviral and pro-inflammatory activity, has been used as an immune modulatory treatment of multiple sclerosis (MS). The…
2018 American Transplant Congress
Effect of Erythropoietin on Cardiac Allograft Survival in Non-Human Primates
J. O.,¹ K. Robinson,¹ W. Sommer,¹ K. Pruner,¹ J. Paster,¹ M. Hanekamp,¹ A. Dehnadi,¹ I. Rosales,¹ R. Smith,¹ P. Cravedi,² P. Heeger,² G. Benichou,¹ J. Madsen.¹
¹MGH, Boston; ²Icahn School of Medicine at Mount Sinai, New York.
Purpose: Tolerance of cardiac allografts has been achieved in cynomolgus monkeys for the first time via mixed hematopoietic chimerism and donor kidney co-transplantation, but the…
2018 American Transplant Congress
Characterization of Mycobacterium Tuberculosis Memory T Cell Subsets in Solid Organ Transplant Recipients with Previously Treated Active Tuberculosis
S. Nellimarla, Y. Natori, V. Ferreira, S. Husain, A. Humar, D. Kumar.
UHN, Toronto, Canada.
Introduction:Cell-mediated immune (CMI) responses including CD4+ and CD8+ T-cells contribute to control of Mycobacterium tuberculosis (MTb) infection. There are no data on long term TB-specific…
2018 American Transplant Congress
The Mark of Zorro: IL35-Coated Exosomes Cross-Dress and Exhaust Recipient T & B Cells during Transplant Tolerance
W. Burlingham,¹ J. Sullivan,¹ D. Lema,¹ Y. Tomita,² Y. Zhou,¹ D. Vignali.³
¹Surgery, University of Wisconsin, Madison, WI; ²Surgery, Tokyo Women's Hospital, Tokyo, Japan; ³Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA.
The folk-hero "Zorro" left his mark on by a sword-slashed "Z". In transplant recipients, rare Tregs also leave a mark on their conventional T &…
2018 American Transplant Congress
A 3C Approach Drives Epigenetic Fixation of Foxp3 Expression and Stabilizes Treg Cell Lineage and Therapeutic Function
X. Xiao, X. Zhang, J. Li, S. Chen, P. Lan, Y. Dou, W. Chen, X. Li.
Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX.
The instability of the regulatory T (Treg) cell lineage precludes their therapeutic potential in transplantation and autoimmune diseases. Herein, we invented a novel approach to…
2018 American Transplant Congress
In Vitro α-Galactosylceramide Stimulation Expands CD4⁺CD25⁺Foxp3⁻ Regulatory T Cell Precursors in Murine Thymocytes
H. Katsumata,^1,2 M. Ikemiyagi,¹ T. Kanzawa,¹ H. Fukuda,¹ R. Ishii,¹ K. Saiga,^1,3 M. Okumi,¹ Y. Ishii,⁴ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; ³Urology, Jyoban Hospital of Tokiwa Foundation, Fukushima, Japan; ⁴Laboratory for Immunotherapy, Center for Integrative Medical Sciences (IMS) RIKEN, Yokohama, Japan.
Background: We previously established mixed chimerism after invariant natural killer T-cell stimulation by administration of liposomal α-galactosylceramide (lipo-αGC) and costimulatory blockade, leading to regulatory T…