2019 American Transplant Congress
Development of De Novo DSA after Kidney Transplant Correlates with Low Quantity of Peripheral Blood “Antibody-Suppressor” CD8+ T Cells
*Purpose: It is well known that CD4+ T cells provide “help” for antibody production in vivo. Our group discovered a novel subset of murine antibody-suppressor…2019 American Transplant Congress
Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection
*Purpose: Regulatory T cells (Treg) restrain allograft rejection through suppressor functions that are dependent upon expression of the transcription factor Foxp3, their proper migration, and…2019 American Transplant Congress
Comparative Use of Single mTOR vs Dual mTOR/PI3K Inhibition in Regulatory T Cell Expansion for Clinical Application in Transplantation
University of Kentucky, Lexington, KY
*Purpose: Experimental and pre-clinical evidence suggest that adoptive transfer of regulatory T cells (Tregs) could be an appropriate therapeutic strategy to induce tolerance and improve…2019 American Transplant Congress
TORC1 Inhibition In Vitro and in a Humanized Mouse Model Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, BWH/Harvard Medical School, Boston, MA
*Purpose: Optimizing Regulatory T cells (Tregs) survival is of utmost importance to maximize the efficacy of utilizing them in adoptive cell therapy. We previously described…2019 American Transplant Congress
FcγRIIB is a Novel CD8+ Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients
*Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…2019 American Transplant Congress
The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection
*Purpose: Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We…2019 American Transplant Congress
Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates
*Purpose: The T-box transcription factors Eomesodermin (Eomes) and T-bet play a critical role in differentiation and function of CD8+ memory T cells (Tmem). We have…2019 American Transplant Congress
Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity
*Purpose: The gut microbiota driven inflammatory response and the host immune system engage bidirectional regulation of each other. These interactions are poorly characterized in organ…2019 American Transplant Congress
Antibody-Suppressor CD8+ T Cells Require CXCR5
*Purpose: We previously reported the novel activity of alloprimed CD8+ T cells that suppress post-transplant alloantibody production. The purpose of the current study was to…2019 American Transplant Congress
Circulating Donor T and NK Cells in Lung Transplantation Recipients Are Derived from the Donor Lung Parenchyma and Represent Tissue-Resident Memory Cells
*Purpose: We previously identified donor lymphocytes in peripheral blood of recipients directly after transplantation and persisting at least three weeks that were characterized by the…
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