2019 American Transplant Congress
Comparison with Solid Organ Transplants Reveals Distinct Face Transplant Rejection Gene Signature That Reflects the Unique Immunobiology of Skin
Brigham and Women's Hospital, Boston, MA
*Purpose: Skin containing transplants, such as face transplants, are immunologically unique. We compared the gene expression profiles of acute cellular rejection in human face transplants…2019 American Transplant Congress
Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients
*Purpose: Investigate the peripheral blood levels of CD4+CD25+FOXP3p3+ regulatory T cells (Tregs) in patients with kidney transplant at least one year after kidney transplantation and…2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…2019 American Transplant Congress
Sphingosine 1-Phosphate Receptor 2 Regulates Migration through Endothelial Cell VCAM and Adherens Junctions
*Purpose: Lymphatic endothelial cells (LEC) highly expres S1PR1 and S1PR2. The ligand S1P is produced by LEC and regulates T cell migration. The mechanisms of…2019 American Transplant Congress
Tissue Resident Memory T Cells in Murine Renal Transplantation
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2019 American Transplant Congress
Predicting Risk of Cytomegalovirus with Viral-Antigen-Specific CD154+ T-cells after Liver or Intestine Transplantation
Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Cytomegalovirus (CMV)-specific T-cells express IFNγ, measure cell-mediated immunity to CMV and can guide the timing and duration of antiviral therapy. CMV-specific T-cells also co-express…2019 American Transplant Congress
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity
*Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…2019 American Transplant Congress
Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model
*Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…2019 American Transplant Congress
Targeting Cell Metabolism for Efficient Large-Scale Expansion of Functional Regulatory T Cells
University of Kentucky, Lexington, KY
*Purpose: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…2019 American Transplant Congress
Age-Related Effects on Thymic Output and Homeostatic T Cell Expansion Following Depletional Induction
Surgery, Duke University, Durham, NC
*Purpose: Alemtuzumab induction leads to profound T cell depletion followed by a prolonged period of repopulation. Repopulation is thought to be influenced both by thymic…
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