Articles tagged "T cells"

2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
E. Bernaldo de Quirós¹, R. López¹, V. Pérez¹, M. Clemente², J. Gil-Jaurena³, M. Camino⁴, N. Gil⁴, E. Panadero⁴, C. Medrano⁴, M. Pion¹, R. Correa-Rocha¹
¹Laboratory of Immune-regulation, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ²Cell Culture Unit, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain, ³Pediatric Cardiac Surgery Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Pediatric Cardiology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…
2019 American Transplant Congress
Treg And Bone Marrow Infusion Promotes Survival Of Donor Kidney Grafted Months After Disappearance Of Mixed Chimerism
K. Bruestle, P. Alonso-Guallart, E. Lopes, G. Pierre, N. Llore, H. Sakai, S. Kofman, D. Ekanayake-Alper, M. Sykes, A. Griesemer
Columbia Center for Translational Immunology, Columbia University, New York City, NY
*Purpose: Transient mixed chimerism induced with non-myeloablative conditioning in monkeys and humans induces tolerance to about 70% of donor kidney grafts transplanted at the time…
2019 American Transplant Congress
In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers
K. Shimozawa, K. Janec, L. Contreras-Ruiz, E. C. Guinan
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…
2019 American Transplant Congress
Gene Expression Profiles in CD8+ T Cells in Chronic Antibody-Mediated Rejection (CAMR) of Kidney Transplantation
P. Pontrelli¹, F. Rascio², M. Accetturo¹, G. Castellano¹, S. Simone¹, G. Stallone², L. Gesualdo¹, G. Grandaliano²
¹Department of Emergency, and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy, ²Dept. of Surgical and Medical Sciences, Nephrology Unit, University of Foggia, Foggia, Italy
*Purpose: CAMR is the main cause of chronic graft injury and subsequent graft loss. Most of the studies on the subject focused their attention to…
2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
L. Contreras-Ruiz¹, K. Shimozawa², R. Zhang¹, L. Turka³, J. F. Markmann³, E. C. Guinan²
¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ²Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Center of Transplantation Sciences, Massachussetts General Hosp., Boston, MA
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…
2019 American Transplant Congress
Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells Regulates Treg Migration and Allograft Protection
V. Saxena, W. Piao, L. Li, C. M. Paluskievicz, Y. Xiong, T. Simon, J. S. Bromberg
U Maryland, Baltimore, MD
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…
2019 American Transplant Congress
Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent
I. Adam¹, B. Motyka², L. West³
¹Medical Microbiology & Immunology, University of Alberta, Edmonton, AB, Canada, ²Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, Surgery, Immunology, Lab Medicine & Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO-incompatible organ transplants (ABOi-Tx) are at high risk of rapid rejection mediated by preformed ABO antibodies (Ab) except during infancy when they are absent.…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration
Y. Xiong¹, W. Piao¹, C. Brinkman¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁵, S. Schwab⁶, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's hospital, Boston, MD, ⁵U.Minnesota, Minneapolis, MN, ⁶NYU, NY, NY
*Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…
2019 American Transplant Congress
Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade
H. Zhang¹, J. Wu², D. Zou³, W. Chen³
¹The second Xiangya Hospital, Changsha, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Immunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston, TX
*Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…
2019 American Transplant Congress
Impact of Early Borderline Histological Changes on Subsequent Events in Renal Transplant Recipients
R. Mehta, S. Tandukar, D. Jorgensen, I. Owoyemi, N. Shah, C. Puttarajappa, C. Wu, S. Hariharan
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The significance of borderline changes suspicious for rejection noted on early renal allograft biopsies on subsequent events in renal transplant recipients is unclear.*Methods: Between…