2020 American Transplant Congress
Effector Differentiation of Endogenous Antigen-Specific CD8+ T Cells is Selectively Limited by CTLA-4 Ig
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: Costimulation blockade with belatacept (CTLA-4 Ig) offers improved renal function and reduced toxicity following transplantation compared to calcineurin inhibitors. Nonetheless, episodes of acute T…2020 American Transplant Congress
Granulocyte-Colony Stimulating Factor (G-CSF) and Granulocyte-Macrophage CSF (GM-CSF) Administration Enriches for Highly Suppressive CD4+CD45RA–Foxp3hi Cells in Leukapheresis Products of Rhesus Monkeys
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: In humans, CD4+CD45RA-Foxp3hi T cells comprise a regulatory T cell (Treg) subset with highly suppressive function. We have previously shown that granulocyte-colony stimulating factor…2020 American Transplant Congress
Novel Insights Into High Alloantibody Production in CCR5 KO Recipient Mice
*Purpose: Antibody-mediated rejection (AMR) contributes to both early and late kidney allograft loss. Unfortunately, conventional immunosuppressants do not effectively control development of humoral alloimmunity in…2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
1Starzl Transplantation Institute, Pittsburgh, PA, 2American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2020 American Transplant Congress
Use of Subunit Herpes Zoster Vaccine in VZV-Seronegative Transplant Recipients to Prevent Primary Varicella
*Purpose: Varicella-zoster virus (VZV) primary infection can be prevented by using the live varicella vaccine. However, this is contraindicated after organ transplant. We investigated the…2020 American Transplant Congress
Polyfunctional Cytokine Secreting Th17 Cells Preferentially Infiltrate Murine Renal Allografts with Acute Rejection and Are Associated with Elevated Th17: Treg Ratio
*Purpose: Our group has shown that renal transplant patients with acute rejection have elevated blood mRNA RORγt: FOXP3 ratio compared to patients with stable graft…2020 American Transplant Congress
Targeting CD4+ T Cell Metabolism Prolongs Graft Survival Age-Specifically
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…2020 American Transplant Congress
Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity
1UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4) are lymph node (LN) stromal fibers whose expression ratio influences CD4+ T cell migration and stimulation. We hypothesized…2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…2019 American Transplant Congress
Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells Regulates Treg Migration and Allograft Protection
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…
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