Articles tagged "T cells"

2020 American Transplant Congress
Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…
2020 American Transplant Congress
Influence of Microbial Communities on Transplantation
K. Janek¹, J. Fechner¹, K. Krautkramer², S. Sudakaran³, J. Denu⁴, J. Handelsman³, F. Rey⁵, E. Vivas⁵, J. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Wisconsin Institute for Discovery, Madison, WI, ⁴Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, ⁵Bacteriology, University of Wisconsin-Madison, Madison, WI
*Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
2020 American Transplant Congress
Challenges in Manufacturing Clinically Competent Regulatory T Cells from Obese Renal Transplant Recipients
F. Marti, A. Ruffing, E. Chacon, L. Turcios, D. Valvi, J. Gonzalez, R. Gedaly
Surgery, University of Kentucky, Lexington, KY
*Purpose: The obesity epidemic has expanded rapidly over the last decade. Our program is developing a novel clinical protocol using expanded autologous regulatory T cell…
2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
2020 American Transplant Congress
High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction
R. Bellmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. Bläsing¹, F. Ius², W. Sommer², J. Kühne¹, L. Horn¹, A. Knöfel², I. Tudorache², A. Haverich², D. Jonigk³, G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, ³Institute of Pathology, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
2020 American Transplant Congress
T Follicular Regulatory Cell Deficiency Enhances Secondary T Follicular Helper Cell Responses after Transplantation
E. S. Crichton, S. Zeng, I. Badell
Emory University, Atlanta, GA
*Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
2020 American Transplant Congress
Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation
C. Aschauer¹, K. Jelencsics¹, K. Hu¹, R. Reindl-Schwaighofer¹, J. Vetter², A. Heinzel¹, A. Kainz¹, G. Gualdoni¹, S. Schaller², S. Winkler², R. Oberbauer¹
¹Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, ²Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg im Muehlkreis, Austria
*Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…
2020 American Transplant Congress
Treg Stability Depends on Lymphotoxin Beta Receptor-Driven Migration
V. Saxena, W. Piao, L. Li, Y. Xiong, C. Palusckievicz, T. Simon, M. Shirkey, R. Abdi, J. S. Bromberg
University of Maryland, Baltimore, Baltimore, MD
*Purpose: Regulatory T cell (Treg) suppressor function for allograft survival requires maintenance of transcription factor Foxp3 and sequential migration from tissues to lymph nodes (LN).…
2020 American Transplant Congress
Treg Lymphotoxin Signals Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interaction
W. Piao¹, R. Oakes², C. Paluskievicz¹, Y. Xiong¹, L. Li¹, V. Saxena¹, M. WillsonShirkey¹, C. Jewell², J. Bromberg¹
¹Surgery, U of Maryland, Baltimore, MD, ²U of Maryland, College Park, MD
*Purpose: Immune suppressive therapy can be complicated by malignancy. Regulatory T cells (Treg) control immune tolerance for graft survival but cause to immune suppression in…
2020 American Transplant Congress
Stability of Immune Phenotype, Alloreactive, and Antiviral Immunity after Switch to Belatacept-Based Regimen after Kidney Transplantation
J. Schaenman, M. Rossetti, H. Wilhalme, V. Groysberg, G. Sunga, J. Gadzhyan, B. Abdalla, E. Lum, P. Pham, G. Danovitch, J. Veale, H. A. Gritsch, D. Elashoff, E. Reed, S. Bunnapradist
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: This investigator-initiated study examines the impact of belatacept on T cell immune phenotype and function.*Methods: 19 patients with evidence of calcineurin inhibitor (CNI) toxicity…