Articles tagged "T cells"

2020 American Transplant Congress
Intra-Lymph Node Injection of Microparticles Reprograms the Laminin Stromal Network to Prolong Allograft Survival
C. M. Paluskievicz¹, Y. Xiong¹, W. Piao¹, M. Willson-Shirkey¹, H. Eppler², C. M. Jewell², J. S. Bromberg¹
¹U Maryland, Baltimore, MD, Baltimore, MD, ²U Maryland, College Park, MD, College Park, MD
*Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) to induce pro-inflammatory or anti-inflammatory responses. We hypothesized…
2020 American Transplant Congress
Antibody-Suppressor CD8⁺ T Cells Ameliorate Antibody-Mediated Rejection Following Kidney Transplant in Mice
J. M. Zimmerer¹, J. L. Han¹, Q. Zeng², B. A. Ringwald¹, C. Cassol¹, R. Warren¹, M. Abdel-Rasoul¹, C. K. Breuer², G. L. Bumgardner¹
¹Ohio State University, Columbus, OH, ²Nationwide Children's Hospital, Columbus, OH
*Purpose: We previously reported the novel alloantibody suppressor activity of alloprimed CXCR5+IFN-γ+CD8+ T cells following hepatocellular transplant in mice. We utilized a murine kidney transplant…
2020 American Transplant Congress
Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell
G. Queipo¹, A. Hernandez-Mendoza¹, M. Estrada-Matus², M. Fonseca-Sanchez¹, F. Oviedo¹, L. García-Cobarruvias³, J. Prieto Chávez⁴, L. Pizarro⁵, L. Morales-Buenrostro⁶
¹Human Genetics, Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, ²Nephrology, Instituno Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Transplant Unit, Hospital General de Mexico-Eduardo Liceaga, Mexico City, Mexico, ⁴Flow Cytometry Core, Mexican Social Security Institute, Mexico City, Mexico, ⁵Unit on Immunochemistry, Medical Research, Specialties Hospital of the National Medical Centre “SigloXXI”, Mexico City, Mexico, ⁶Nephrology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico
*Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…
2020 American Transplant Congress
Treg-Lymphatic Interfaces: Unique Molecular Structures for Cell-Cell Interactions During Migration
C. M. Paluskievicz, W. Piao, Y. Xiong, J. S. Bromberg
U of Maryland, Baltimore, MD
*Purpose: To promote transplant tolerance, T regulatory cells (Treg) must enter the afferent lymphatic vasculature by migrating across lymphatic endothelial cells (LECs), and then home…
2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
R. Dziarmaga¹, D. Ke¹, V. Phan², H. Cardinal³, R. Sapir-Pichhadze¹, C. A. Piccirillo¹, B. Mazer¹, B. Foster¹
¹Research Institute - McGill University Health Centre, Montreal, QC, Canada, ²Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada, ³Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…
2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
L. Belyayev¹, M. Sadat², J. Kang², K. Loh², A. Duttargi², S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. Fishbein², A. Kroemer²
¹Walter Reed National Military Medical Center, Bethesda, MD, ²MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
2020 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
A. Angeletti¹, C. Donadei¹, G. Donati¹, G. Di Certo¹, D. Conte¹, L. Gasperoni¹, E. Pelizzaro¹, C. Guglielmo¹, G. Comai¹, P. Cravedi², G. La Manna¹
¹DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, ²DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
2020 American Transplant Congress
PD-L1 Signals Lymphatic Endothelium for Treg Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena³, Y. Xiong¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar², L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²Pediatrics, U of Minnesota, Minneapolis, MN, ³U of Maryland, Baltimore, MD, ⁴Transplantation Research Center, Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
B. Kim¹, E. Kim², J. Kim², H. Choi³, H. Lee², J. Lee⁴, M. Kim⁴, Y. Kim⁴, K. Huh⁴
¹Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…