Articles tagged "T cells"

2020 American Transplant Congress
The Requirement of Thymic Irradiation for Induction of Mixed Chimerism and Renal Allograft Tolerance in Non-Human Primates
T. Hirose¹, H. Sasaki¹, T. Oura¹, D. Ma¹, A. Dehnadi¹, R. B. Colvin², I. Rosales², A. B. Cosimi¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: Thymic irradiation (TI) has been required for consistent induction of allograft tolerance through a mixed chimerism approach in both murine and nonhuman primate (NHP)…
2020 American Transplant Congress
Pre- And Post-Transplant (Tx) Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Treatment Increased Regulatory T Cell (Treg) Percentage in CD4+ T Cells in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts)
S. Ge¹, M. Chu¹, E. D. Ortiz¹, A. D. Guzman¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6 is a B cell growth factor and pro-inflammatory cytokine. Inhibition of IL-6 signaling modulates B cell activation and inflammatory process possibly through Treg…
2020 American Transplant Congress
Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation
L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. K. Dwyer², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. R. Turnquist¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Immunology, University of Pittsburgh, Pittsburgh, PA, ³Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA
*Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…
2020 American Transplant Congress
Role of CAR-T Cell Therapy in Post Transplant Lymphoproliferative Disorder
S. Krishnamoorthy, A. Malone, R. Delos Santos, H. Murad, T. Alhamad
Transplant, Washington University in St. Louis, Saint Louis, MO
*Purpose: Chimeric Antigen Receptor (CAR) T cells are a genetically modified autologous immunotherapy that uses a patient’s own T cells modified with a chimeric antigen…
2020 American Transplant Congress
Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan³, P. Cravedi⁴, P. S. Heeger⁴, G. Benichou¹, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
2020 American Transplant Congress
Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts
L. Wang¹, Z. Wang², R. Han¹, A. Samanta¹, G. Ge¹, L. S. Levin¹, M. H. Levine¹, W. W. Hancock³
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…
2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
H. Liu, Y. Chen, F. Qiu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
2020 American Transplant Congress
CCL18 Plays a Crucial Role in T Cell Recruitment in Upper Extremity Transplant Rejection
T. J. Borges¹, P. Abarzua², B. Kollar², M. Lima-Filho¹, B. T. Aoyama¹, G. F. Murphy², B. Pomahac², C. G. Lian², S. G. Talbot², L. V. Riella¹
¹Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
*Purpose: Upper extremity transplantation (UET) is a life-changing procedure for amputee patients. However, 90% of patients experience acute skin rejection in the first post-transplant year,…
2020 American Transplant Congress
Foxp3⁺ Innate and TGF-ß⁺ Adaptive Regulatory Immune Cells in Quilty Lesions are Associated with Acceptance of Heart Allograft
S. A. Moore, C. K. Metter, Q. Cai, J. R. Torrealba
University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: To evaluate the cellular composition of Quilty lesions in heart transplant biopsies and their association with acceptance or rejection of cardiac allografts.*Methods: This study…
2020 American Transplant Congress
B₂-Adrenergic Receptor Activation in Donor Cells Inhibits T Cell Trafficking in Vascularized Composite Tissue Allotransplants
M. Kim¹, D. Fisher¹, J. Loo¹, P. Bogner², U. Sharma³, J. Skitzki¹, E. Repasky⁴
¹Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ²Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Cardiology, University at Buffalo, Buffalo, NY, ⁴Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
*Purpose: Transplantation of faces, hands, and limbs using vascularized composite allotransplantation (VCA) has faced significant challenges hindering its routine implementation in the clinic. One critical…