Articles tagged "T cells"

2020 American Transplant Congress
Examination of the TIGIT/CD226 Axis in Kidney Transplant Recipients
G. J. Kavalam, A. D. Desai, A. Chandraker, S. Tripathi
Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) and CD226, two poliovirus receptor-like proteins, are an emerging group of immune checkpoints with…
2020 American Transplant Congress
Donor Kidney Perfusion Fluid Extracellular Vesicles as Markers of Graft Function
A. K. Rutman, S. Negi, N. Saberi, J. Tchervenkov, S. Paraskevas
Research Institute of the McGill University Health Institute, Montreal, QC, Canada
*Purpose: Kidney transplantation is a life-saving treatment for many patients with end-stage renal failure. Recently, machine perfusion of kidneys prior to transplantation has emerged as…
2020 American Transplant Congress
Simultaneously Detection of ddcfDNA in Plasma and Urine Assist to Determine the Type of Rejection in Renal Transplant Patients
D. Cheng¹, F. Liu², H. Liu², T. Jiang², Y. Zhou³, L. Shu², X. Li¹, K. Xie¹, X. Ni¹, J. Chen¹, J. Ge², Z. Liu¹, H. Shi³
¹Jinling Hospital Nanjing University, Nanjing, China, ²AlloDx, Shanghai; Suzhou, China, ³Jiangsu University, Zhenjiang, China
*Purpose: The correct diagnosis and treatment of acute rejection (ABMR and TCMR) are the key to the long-term survival after renal transplantation. Renal biopsy is…
2020 American Transplant Congress
T Cell Dysfunction as Measured by Impaired Antigen Response is Associated with Infection and Frailty in Kidney Transplant Recipients
J. Schaenman, M. Rossetti, V. Groysberg, G. Sunga, E. Liang, S. Bunnapradist, E. Reed
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Kidney transplant recipients are at risk for infection, especially the growing numbers of older patients. Our previous studies demonstrated that senescent and exhausted T…
2020 American Transplant Congress
A Novel Immunoresponse Monitoring System to Predict Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
N. Iwahara¹, K. Hotta¹, D. Iwami¹, Y. Takada¹, H. Higuchi², H. Sasaki², T. Tanabe², N. Shinohara¹
¹Hokkaido University, Sapporo, Japan, ²Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody mediated rejection (CAAMR) induced by de novo donor specific antibodies (DSA) is the main cause of graft loss in the long-term.…
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
2020 American Transplant Congress
Non-Human Primate B Cells Into Regulatory B Cells by Activation with CpG
K. Lee¹, C. Rickert¹, K. Deng¹, N. Feeney¹, N. Tanimine², Q. Fu¹, G. Huai¹, J. Lei¹, C. Leguern¹, J. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Gastroenterological Transplantation Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: We previously generated Toll like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed…
2020 American Transplant Congress
Utility of dd-cfDNA in TCMR 1A and Borderline Allograft Rejection
E. Stites¹, D. Kumar², O. Olaitan³, G. Gupta²
¹University of Colorado, Aurora, CA, ²Virginia Commonwealth University, Richmond, VA, ³Rush University, Chicago, CA
*Purpose: The value of donor-derived cell-free DNA (dd-cfDNA, AlloSure) as a molecular marker for the early diagnosis of mild T-cell mediated rejection (Banff TCMR 1A…
2020 American Transplant Congress
DEPTOR Expression within CD4⁺Foxp3⁺ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
J. Wedel¹, M. Maslyar¹, S. Kong¹, M. Laplante², D. M. Briscoe¹
¹Boston Children's Hospital, Boston, MA, ²Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
2020 American Transplant Congress
Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection
A. J. Matar¹, B. P. Lovasik¹, D. Vanover², L. Rotolo², Y. Dong¹, D. A. Faber¹, D. V. Mathews¹, W. H. Kitchens¹, P. Santangelo², A. B. Adams¹
¹Surgery and Transplantation, Emory University, Atlanta, GA, ²Biomedical Engineering, Georgia Tech, Atlanta, GA
*Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…