2020 American Transplant Congress
Tracking Tregs in a Non-Human Primate Model with Expanded Autologous Treg Infusions In Vivo
*Purpose: Regulatory Tcell (Treg) therapy is a promising tool for tolerance induction in solid organ transplantation. Despite encouraging results in humans and monkeys, questions about…2020 American Transplant Congress
Flow Cytometric Characterization of Regulatory Cell Populations Expanded Ex Vivo from PBMCs of Kidney Transplant Recipients
*Purpose: We have previously shown that it is possible to generate alloantigen-specific regulatory T cell lines and clones that prolong allograft survival upon infusion in…2020 American Transplant Congress
Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Rodent studies have demonstrated the utility of regulatory T cell (Treg) infusion for the promotion of tolerance to organ allografts. Here, we evaluated the…2020 American Transplant Congress
The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation
University of Maryland, Baltimore, Baltimore, MD
*Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…2020 American Transplant Congress
Intra-Lymph Node Injection of Microparticles Reprograms the Laminin Stromal Network to Prolong Allograft Survival
1U Maryland, Baltimore, MD, Baltimore, MD, 2U Maryland, College Park, MD, College Park, MD
*Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) to induce pro-inflammatory or anti-inflammatory responses. We hypothesized…2020 American Transplant Congress
Antibody-Suppressor CD8+ T Cells Ameliorate Antibody-Mediated Rejection Following Kidney Transplant in Mice
1Ohio State University, Columbus, OH, 2Nationwide Children's Hospital, Columbus, OH
*Purpose: We previously reported the novel alloantibody suppressor activity of alloprimed CXCR5+IFN-γ+CD8+ T cells following hepatocellular transplant in mice. We utilized a murine kidney transplant…2020 American Transplant Congress
Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell
*Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…2020 American Transplant Congress
Treg-Lymphatic Interfaces: Unique Molecular Structures for Cell-Cell Interactions During Migration
*Purpose: To promote transplant tolerance, T regulatory cells (Treg) must enter the afferent lymphatic vasculature by migrating across lymphatic endothelial cells (LECs), and then home…2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
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