Articles tagged "T cells"

2020 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. C. Palusckievicz¹, T. Simon¹, M. W. Shirkey¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland, Baltimore, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…
2020 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou Daya, D. Zhao, K. Biery, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
2020 American Transplant Congress
Autologous Expanded Tregs Promote Bone Marrow Engraftment and Donor Kidney Survival in Non-Human Primate Chimerism Model
K. Bruestle¹, P. Alonso-Guallart¹, H. Sakai¹, F. Fredriksson¹, B. Piegari¹, E. Lopes¹, G. Pierre¹, A. Shou¹, D. Ekanayake-Alper¹, J. Weiner¹, A. Iuga², S. M. Coley², M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York City, NY, ²Department of Pathology and Cell Biology, Columbia University, New York City, NY
*Purpose: Mixed chimerism (MC) induced with non-myeloablative conditioning in monkeys and humans induces tolerance to 70% of kidney grafts transplanted at the time of BMT.…
2020 American Transplant Congress
ESAT-6, A Novel Protein Originally Produced by M. Tuberculosis, Inhibits Central Memory CD8+ T Cell Generation and Allograft Rejection
F. Qiu, S. Ye, H. Liu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Allospecific memory T cells pose a threat to long-term allograft survival since they are somewhat resistant to immunosuppression. The objective of this study is…
2020 American Transplant Congress
PD-1 Signals Murine and Human Treg for Enhanced Migration
W. Piao¹, Y. Xiong¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar³, L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³Surgery, U of Minnesota, Minneapolis, MN, ⁴Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Programmed death-1 (PD-1) attenuates immune responses. Engagement of PD-1 by its ligands PD-L1 or PD-L2 regulates T cell development, proliferation, cytokine production, and apoptosis.…
2020 American Transplant Congress
Role of Peptide Antigen, Antigen-Presenting Cells and CD4 T Cells in Modulating BK Polyomavirus (BKPyV)-Specific CD8 T Cell Responses In Vitro
M. Wilhelm, A. Kaur, M. Wernli, H. H. Hirsch
Biomedicine, University of Basel, Basel, Switzerland
*Purpose: BKPyV persists as significant cause of premature kidney transplant failure. Current treatment is based on reducing immunosuppression to regain immune control over BKPyV replication…
2020 American Transplant Congress
Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways
X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
S. Ge¹, M. Chu¹, A. D. Guzman¹, E. D. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…
2020 American Transplant Congress
Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways
S. Chung, S. Choi
Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of
*Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
2020 American Transplant Congress
Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients
L. Zaffiri¹, J. E. Messinger², J. Yi², K. J. Weinhold², G. Ferrari², M. Luftig², S. M. Palmer¹
¹Pulmonary and Critical Care, Duke University, Durham, NC, ²Duke University, Durham, NC
*Purpose: After lung transplantation, Epstein-Barr virus (EBV) is a common opportunistic infection. The significance of EBV viremia following solid organ transplantation (SOT) remains unclear. Host…