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Articles tagged "T cell receptors (TcR)"

  • 2019 American Transplant Congress

    TCR Transgenes to Understand Human Xenotolerance Induction

    G. Nauman, C. Borsotti, N. Danzl, M. Khosravi-Maharlooei, H. Li, E. Chavez, Y. Yang, M. Sykes

    Columbia Center for Translational Immunology, New York, NY

    *Purpose: Swine thymus transplantation is a promising approach to clinical tolerance for pig-to-human xenotransplantation. In humanized mice, a swine thymus graft supports de novo selection…
  • 2018 American Transplant Congress

    Altered Function of Cytomegalovirus Specific T Cells in Transplant Recipients

    L. Higdon,1 J. Trofe-Clark,2 S. Liu,1 N. Saligrama,1 K. Margulies,2 M. Davis,1 J. Maltzman.1,3

    1Stanford U, Stanford, CA; 2U Pennsylvania, Philadelphia, PA; 3VA Palo Alto, Palo Alto, CA.

    Background: Cytomegalovirus (CMV) reactivation is associated with increased morbidity and mortality in transplant recipients. CMV establishes latency for the host's lifetime and frequently reactivates. Immunosuppression,…
  • 2018 American Transplant Congress

    Identifying Specificity Groups in the CMV IE-1 T Cell Receptor Repertoire

    M. Lucia,1 F. Rubelt,2 S. Luque,3 S. Krams,1 C. Esquivel,1 O. Bestard,3 O. Martinez.1

    1Department of Surgery, Stanford University, Palo Alto; 2Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto; 3Experimental Nephrology, IDIBELL, Barcelona, Catalonia, Spain.

    Cytomegalovirus (CMV) continues to be a major problem for organ transplant recipients. T cells specific to the CMV antigens immediate-early (IE-1) and pp65 CMV govern…
  • 2018 American Transplant Congress

    TLR2 with TCR Signaling Mobilizes Treg Lymphatic Migration

    W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.

    UMB, MD.

    Background: Regulatory T cells (Treg) express high levels of lymphotoxin (LT) and bind the LT receptor (LTβR) on lymphatic endothelial cells (LEC). This receptor-ligand interaction…
  • 2017 American Transplant Congress

    Evaluation of Function and TCR signaling Profile of CD57+ T Cells in Allo-Specific Immunity.

    H. Xu,1 T. Brennan,1 Q. Li,2 A. Kirk.1

    1Department of Surgery, Duke University School of Medicine, Durham, NC; 2Department of Immunology, Duke University School of Medicine, Durham, NC

    Our studies have showed that CD57+ cells are resistant to B7 costimulation blockade (CoB). We hypothesize that CD57+ cells are highly sensitive to T cell…
  • 2017 American Transplant Congress

    BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.

    U. Stervbo,1,2 M. Nienen,1 B. Weist,2 P. Wehler,2 T. Westhoff,1 H.-D. Volk,2 P. Reinke,2 N. Babel.1,2

    1Center for Translational Medicine, Medical Clinic I, Marienhospital Herne, University Hospital of the Ruhr-University Bochum, Bochum, Germany; 2Berlin-Brandenburg Center for Regenerative Therapies, Charité – University Medicine, Berlin, Germany

    Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression…
  • 2017 American Transplant Congress

    Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.

    T. Win,1 N. Murakami,2 I. Avraham-Davidi,1 J. Teague,1 E. Lowry,1 R. Lopdrup,1 E. Bueno,1 A. Chandraker,1 L. Riella,1 B. Pomahac,1 R. Clark.1

    1Brigham and Women's Hospital, Boston; 2Broad Institute of MIT and Harvard, Cambridge

    BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…
  • 2017 American Transplant Congress

    In Depth Characterization of Ex Vivo Expanded Polyclonal Regulatory T Cells Used in a Phase I Clinical Trial Following Kidney Transplantation.

    J. Heinrichs,1 J. Mathew,1,2 I. Konieczna,1 J. He,1 X. Haung,1 A. LeFever,1 J. Leventhal.1

    1Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL; 2Microbiology and Immunology, Northwestern University, Chicago, IL

    Initial clinical trials have investigated the safety of regulatory T cells (Tregs) as a therapy during aberrant immune activation, like graft-versus-host disease (GVHD) following stem…
  • 2017 American Transplant Congress

    Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).

    Z. Lyu,1 L. Pang,1 G. Zeng,2 Y. Huang,2 P. Randhawa.2

    1Pathology & Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; 2Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…
  • 2017 American Transplant Congress

    Contribution of γδ T-Cell Subsets and IL-17A Release to Ischemia Reperfusion Injury (IRI) and Kidney Allograft Rejection in Mice.

    A. Thorenz,1 S. Rong,1 N. Völker,1 R. Chen,1 J. Bräsen,2 H. Haller,1 C. Klemann,3 F. Gueler.1

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Pathology, Hannover Medical School, Hannover, Germany; 3Pediatric Surgery, Hannover Medical School, Hannover, Germany

    Ischemia reperfusion injury (IRI) contributes to acute allograft injury and to delayed graft function (DGF) which is a trigger for acute rejection after kidney transplantation…
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