ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell reactivity"

  • 2016 American Transplant Congress

    Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.

    M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.

    Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.

    PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
  • 2016 American Transplant Congress

    Clinical Rejection-Risk Assessment with Allospecific CD154+T-Cytotoxic Memory Cells (CD154+TcM) After Pediatric Liver or Intestine Transplantation (LTx, ITx).

    K. Soltys, G. Bond, G. Mazariegos, L. O'Toole, C. Trautz, L. Remaley, A. Zeevi, C. Ashokkumar, R. Sindhi.

    Surgery, Children's Hosp of Pgh of UPMC & Univ of Pittsburgh, Pittsburgh, PA.

    Background: In preclinical evaluation, CD154+TcM predict acute cellular rejection after LTx or ITx with sensitivity/specificity of 80%. Purpose/Methods: To summarize test indications and performance during…
  • 2016 American Transplant Congress

    Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.

    N. Chun,1 M. Zhang,2 R. Fairchild,3 P. Heeger.1

    1Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; 2Anesthesia, SUNY Downstate, NY, NY; 3Immunology, Cleveland Clinic, Cleveland, OH.

    Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…
  • 2015 American Transplant Congress

    MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo

    D. Joyce,1 M. Morita,2 X.-K. Li,3 J. Fung,1 S. Qian,1,2 L. Lu.1,2

    1General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 3Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

    Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
  • 2015 American Transplant Congress

    Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation

    E. Crespo,1 M. Lucia,1 J. Cruzado,1,2 S. Luque,1 E. Melilli,2 A. Manonelles,1,2 N. Sala,2 J. Grinyó,1,2 O. Bestard.1,2

    1Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Nephrology Department and Renal Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.

    Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…
  • 2015 American Transplant Congress

    Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations

    J. Mathew, X. Huang, J. Leventhal, L. Gallon, J. Miller, J. Levitsky.

    Surgery - Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…
  • 2015 American Transplant Congress

    IgM+ Antigen Binding B Cells in Peripheral Blood Regulate IFNγ Production in Response to HLA Proteins

    L. McLaughlin,1 K. Shiu,1 G. Lombardi,1 J. Spencer,2 R. Vaughan,1 A. Dorling.1

    1MRC Centre for Transplantation, King's College London, London, United Kingdom; 2Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom.

    Chronic antibody mediated rejection (CAMR) is a major cause of graft loss in renal transplant recipients. Previous work utilising an IFNγ ELISPOT assay revealed two…
  • 2015 American Transplant Congress

    Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection

    S. Iida,1 T. Suzuki,2 K. Tanabe,1 A. Valujskikh,3 R. Fairchild,3 R. Abe.2

    1Urology, Tokyo Women's Medical Univ, Tokyo, Japan; 2Immunology, Science University of Tokyo, Chiba, Japan; 3Immunology, Cleveland Clinic, Cleveland, OH.

    【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
  • 2015 American Transplant Congress

    miR-155 Different Roles in UCB iTreg and nTreg

    Y. Lu, L. Lu.

    Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

    OBJECTIVES:miR-155 has been associated with both innate and adaptive immune responses. SOCS1, which is involved in Treg survival and function, is a direct target of…
  • 2015 American Transplant Congress

    Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses

    V. Agashe,1 M. Keller,2 L. Haynes,1 E. Jankowska-Gan,1 J. Sullivan,1 J. Kernien,1 H. Suzuki,3 D. Wilkes,4 W. Burlingham.1

    1Surgery, UW Madison, Madison, WI; 2Tulane University, New Orleans, LA; 3Chiba Graduate School of Medicine, Chiba, Japan; 4Indiana University School of Medicine, Indianapolis, IN.

    Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…
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