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American Transplant Congress abstracts

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Articles tagged "T cell reactivity"

  • 2016 American Transplant Congress

    Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.

    M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.

    Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.

    PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
  • 2016 American Transplant Congress

    Clinical Rejection-Risk Assessment with Allospecific CD154+T-Cytotoxic Memory Cells (CD154+TcM) After Pediatric Liver or Intestine Transplantation (LTx, ITx).

    K. Soltys, G. Bond, G. Mazariegos, L. O'Toole, C. Trautz, L. Remaley, A. Zeevi, C. Ashokkumar, R. Sindhi.

    Surgery, Children's Hosp of Pgh of UPMC & Univ of Pittsburgh, Pittsburgh, PA.

    Background: In preclinical evaluation, CD154+TcM predict acute cellular rejection after LTx or ITx with sensitivity/specificity of 80%. Purpose/Methods: To summarize test indications and performance during…
  • 2016 American Transplant Congress

    Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.

    N. Chun,1 M. Zhang,2 R. Fairchild,3 P. Heeger.1

    1Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; 2Anesthesia, SUNY Downstate, NY, NY; 3Immunology, Cleveland Clinic, Cleveland, OH.

    Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…
  • 2015 American Transplant Congress

    Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection

    S. Iida,1 T. Suzuki,2 K. Tanabe,1 A. Valujskikh,3 R. Fairchild,3 R. Abe.2

    1Urology, Tokyo Women's Medical Univ, Tokyo, Japan; 2Immunology, Science University of Tokyo, Chiba, Japan; 3Immunology, Cleveland Clinic, Cleveland, OH.

    【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
  • 2015 American Transplant Congress

    miR-155 Different Roles in UCB iTreg and nTreg

    Y. Lu, L. Lu.

    Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

    OBJECTIVES:miR-155 has been associated with both innate and adaptive immune responses. SOCS1, which is involved in Treg survival and function, is a direct target of…
  • 2015 American Transplant Congress

    Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses

    V. Agashe,1 M. Keller,2 L. Haynes,1 E. Jankowska-Gan,1 J. Sullivan,1 J. Kernien,1 H. Suzuki,3 D. Wilkes,4 W. Burlingham.1

    1Surgery, UW Madison, Madison, WI; 2Tulane University, New Orleans, LA; 3Chiba Graduate School of Medicine, Chiba, Japan; 4Indiana University School of Medicine, Indianapolis, IN.

    Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…
  • 2015 American Transplant Congress

    B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation

    J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.

    Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.

    Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
  • 2015 American Transplant Congress

    Induction of a Costimulation-Susceptible Repertoire: A Case for Depletional Prior to Belatacept

    H. Xu,1 K. Samy,1 A. Guasch,2 S. Mead,2 A. Kirk.1

    1Surgery, Duke University, Durham, NC; 2Transplant Center, Emory University, Atlanta, GA.

    Belatacept offers highly specific costimulation blockade to prevent recipient alloimmune responses with reduced toxicity. However, when applied with nondepletional induction therapy belatacept-based regimens have higher…
  • 2015 American Transplant Congress

    Vaccine-Induced 'Incognito' CD8+ T Cell Memory Can Disrupt Transplantation Tolerance

    M. Nelsen,1 K. Beard,2 R. Kedl,1 R. Gill.2

    1Dept of Immunology & Microbiology, Univ of Colorado, Aurora, CO; 2Dept of Surgery, Univ of Colorado, Aurora, CO.

    Transplant recipients harbor immunity to vaccines and pathogens (e.g. CMV, EBV). Pre-existing immunity can have significant antigen-specific ramifications, usually attributed to heterologous immunity, as pathogen-reactive…
  • 2015 American Transplant Congress

    MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo

    D. Joyce,1 M. Morita,2 X.-K. Li,3 J. Fung,1 S. Qian,1,2 L. Lu.1,2

    1General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 3Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

    Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
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