Articles tagged "T cell reactivity"

2022 American Transplant Congress
Detection of Alloreactive CD8+ T Cell Responses and the Immunopeptidome That Elicits Their Activation
A. B. Morris, X. Zhang, E. V. Peek, A. Hadley, C. Larsen
Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection results in graft dysfunction and contributes to premature failure. Due to the complexity of the TCR:pMHC interaction, prediction of alloreactive T…
2022 American Transplant Congress
T and B Cell Response to 3 Dose Covid Vaccine Series for Kidney Transplant Patients on Belatacept
J. Christensen¹, I. Yakubu², D. Kumar¹, D. Cornett³, M. A. Miller³, M. Altrich³, L. Flebbe-Rehwaldt³, R. Thompson¹, G. Gupta¹
¹Internal Medicine, Transplant Nephrology, VCUHealth, Richmond, VA, ²Pharmacy, VCUHealth, Richmond, VA, ³Eurofins Viracor, Lee's Summit, MO
*Purpose: Data shows COVID vaccine response after 2 doses in patients on Belatacept immunosuppression (IS) is low, with reported rates of seroconversion (as measured by…
2022 American Transplant Congress
Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection
M. Cano¹, D. Zhou², C. Chen³, K. Pugh⁴, D. Byers¹, D. Kreisel⁵, R. Hachem¹, A. Gelman⁵
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, ⁴Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, ⁵Surgery and Immunology and Pathology, Washington University, Saint Louis, MO
*Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
2022 American Transplant Congress
COVID-19 Vaccination Induces a Poor Interleukin-21 Memory T-cell Response in Kidney Transplant Recipients
S. R. Malahe¹, Y. den Hartog¹, R. de Kuiper¹, D. Reijerkerk¹, D. Geers², C. H. GeurtsvanKessel², M. M. Kho¹, R. D. de Vries², M. E. Reinders¹, C. C. Baan¹
¹Internal Medicine, Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Viroscience, Erasmus MC, Rotterdam, Netherlands
*Purpose: COVID-19-related morbidity and mortality is high among kidney patients. Several studies recently suggested low humoral and cellular immune responses after two doses of mRNA-1273…
2022 American Transplant Congress
An Interventional Study Using Cell-Mediated Immunity to Guide Primary Prophylaxis for CMV Infection in Organ Transplant Recipients: A Multi-Center Study
J. T. Solera¹, C. Cervera², S. Hosseini¹, J. Gill³, S. Shalhoub⁴, J. Zaltzman⁵, N. Pinzon¹, A. Humar¹, D. Kumar¹
¹UHN, Toronto, ON, Canada, ²UAlberta, Edmonton, AB, Canada, ³UBC, Vancouver, BC, Canada, ⁴LHSC, London, ON, Canada, ⁵StMH, Toronto, ON, Canada
*Purpose: There are limited interventional studies using CMV cell-mediated immunity to guide the duration of antiviral prophylaxis. We aimed to use CMV CMI to guide…
2022 American Transplant Congress
Acute Graft versus Host Disease (AGVHD) Related to Solid Organ Transplant (SOT) – A Fatal Complication
H. Shaikh¹, J. Awosika¹, B. Barakoti¹, B. Hambley¹, C. Alquist²
¹University of Cincinnati Medical Center, Cincinnati, OH, ²Hoxworth Blood Center, Cincinnati, OH
*Purpose: This case series highlights our institution's experience with solid-organ transplant (SOT) associated acute graft versus host disease (aGVHD), a rare and deadly complication of…
2022 American Transplant Congress
Gm2a Regulates Memory Cd8⁺ T Cell Activation and Differentiation
K. P. Tong¹, K. M. Baecher², C. R. Hartigan¹, M. Ford³
¹Emory University Transplant Center, Emory University, Atlanta, GA, ²Department of Surgery, Emory University, Atlanta, GA, ³Emory University, Atlanta, GA
*Purpose: In a clinical trial, patients who underwent kidney transplantation and were subsequently stable off tacrolimus immunosuppression exhibited increased Gm2a transcript in PBMC relative to…
2022 American Transplant Congress
Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4⁺ Memory T-helper Cells
T. Tomosugi¹, K. Iwasaki², S. Sakamoto³, K. Ftamura¹, M. Okada¹, T. Hiramitsu¹, N. Goto¹, S. Narumi¹, Y. Watarai¹, T. Kobayashi⁴
¹Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ²Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, ³Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ⁴Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
*Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
2022 American Transplant Congress
Low T Cell Responsiveness in the Early Phase Of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
M. Cremoni¹, S. Cuozzo¹, E. Martinuzzi², S. Barbosa², N. Ben Hassen¹, F. Massa³, E. Demonchy⁴, M. Durand⁵, O. Thaunat⁶, V. Esnault¹, M. Lequintrec⁷, S. Caillard⁸, N. Glaichenhaus², A. Sicard¹
¹Service de Néphrologie, Dialyse, Transplantation rénale, Centre Hospitalier Universitaire de Nice, Nice, France, ²CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France, ³Université Côte d'Azur, Laboratoire de Physio-Médecine Moléculaire, Nice, France, ⁴Service d'Infectiologie, Centre Hospitalier Universitaire de Nice, Nice, France, ⁵Service d'Urologie, Centre Hospitalier Universitaire de Nice, Nice, France, ⁶Service de Transplantation rénale, Néphrologie et Immunologie clinique, Hôpital Edouard Herriot, Hospices civils de Lyon, Lyon, France, ⁷Service de Néphrologie, Dialyse, Transplantation rénale, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France, ⁸Service de Néphrologie et Transplantation, Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France
*Purpose: Kidney transplant (KT) recipients are more prone to developing life-threatening forms of COVID-19 than the general population. Little is known about the immunological mechanisms…
2022 American Transplant Congress
Assessment of Humoral and Cellular Immune Responses to Sars Cov-2 Vaccination in Immunocompromised Renal Allograft Recipients
B. Shin, R. Zhang, T. M. Gadsden, A. Petrosyan, A. Vo, N. Ammerman, S. Sethi, E. Huang, A. Peng, R. Najjar, J. Atienza, I. Kim, S. C. Jordan
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: SARS CoV-2 vaccination elicits both robust humoral and T-cell immune responses in healthy individuals. However, a comprehensive assessment of immune responses to SARS-CoV-2 vaccination…

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