2018 American Transplant Congress
CMV-Specific Cell-Mediated Immunity after Valgancyclovir Prophylaxis Predicts Late Onset CMV Infection in Kidney Transplant Patients
Background: There is currently no means to predict late-onset CMV infection after a long course of post-transplant Valgancyclovir prophylaxis therapy and its development still negatively…2018 American Transplant Congress
Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients
Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…2018 American Transplant Congress
Viral-Specific Cytotoxic T-Cell (Viral-Tc) Responses in Highly-HLA-Sensitized Patients (HS) Maintained on Tacrolimus and Everolimus Post-HLAi Kidney Transplant
Introduction: Viral infections represent significant infectious complications post- kidney transplant which may be increased with desensitization. CMV, EBV and BKV infections are the most prevalent.…2018 American Transplant Congress
Altered Function of Cytomegalovirus Specific T Cells in Transplant Recipients
1Stanford U, Stanford, CA; 2U Pennsylvania, Philadelphia, PA; 3VA Palo Alto, Palo Alto, CA.
Background: Cytomegalovirus (CMV) reactivation is associated with increased morbidity and mortality in transplant recipients. CMV establishes latency for the host's lifetime and frequently reactivates. Immunosuppression,…2018 American Transplant Congress
C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms
Icahn School of Medicine at Mount Sinai, NY, NY.
The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…2018 American Transplant Congress
Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells
Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…2018 American Transplant Congress
Human Endothelial-Like Cells Transdifferentiated from Peripheral CD14+ Monocytes Inhibit T Cells in Response to Allo-Stimulation
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
We have previously demonstrated that the endothelial cells located in immune-privilege sites, such as livers, suppress T-cells in response to both of direct and indirect…2018 American Transplant Congress
Assessment of Anti-CMV Immunity by Monitoring Anti-CMV Antibody (CMV-Ab) and CMV-Specific Cytotoxic T Cells (CMV-Tc) in Pediatric Kidney Transplant Recipients (Ped KTx Pts)
Introduction: CMV infection results in significant morbidity in KTx pts, especially CMV sero- ped pts with CMV sero+ donors (D+/R-). CMV infection is controlled primarily…2018 American Transplant Congress
Characterization of Mesenchymal Stem Cell Phenotype and Its Immunomodulatory Effects during Allo-Specific T Cell Immune-Responses
Department of Surgery, Duke University Medical Center, Durham, NC.
Mesenchymal stem cells (MSCs) have been suggested play an important role in modulating cell-mediated immunity. In the setting of transplantation, allogeneic MSCs could mediate suppressive…
American Transplant Congress abstracts