2020 American Transplant Congress
Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial
*Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…2020 American Transplant Congress
Novel Flow-Based Assay to Detect Allospecific T Cells in Transplantation Study
*Purpose: Identifying and phenotyping donor-reactive T cells in recipients following transplantation may further the understanding of interactions between the recipient’s immune system and donor antigen.…2020 American Transplant Congress
Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells
University of Alberta, Edmonton, AB, Canada
*Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…2019 American Transplant Congress
Regulating T Cell Responses by Forced Transgenic Expression of Decay-Accelerating Factor
1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH
*Purpose: Decay-accelerating factor (DAF, CD55) is a cell surface expressed, glycophosphatidylinositol-(GPI)-anchored, complement regulator. Previous studies showed that during cognate T cell/antigen presenting cell (APC) interactions…2019 American Transplant Congress
First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant
1MedStar Georgetown Transplant Institute, Washington, DC, 2University of Pittsburgh, Pittsburgh, PA
*Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…2019 American Transplant Congress
MDSCs Prolong Allogeneic Cardiac Graft Survival by Regulating Interferon Type 1 Signaling
*Purpose: We previously demonstrated that donor-derived regulatory dendritic cells (DCreg), contrary to recipient derived DCreg, promote antigen-specific allograft protection. As myeloid-derived suppressor cells (MDSC) show…2019 American Transplant Congress
The Impact of Biological Behavior of Allograft Infiltrating Lymphocytes during Early Phase
Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan
*Purpose: The graft infiltrating lymphocytes (GILs) build an immunological microenvironment locally. Reportedly the GILs within 72hrs posttransplantation do not attack allograft, but may prevent from…2019 American Transplant Congress
Race-Sex Effects on Immune Response Potential during Tacrolimus Minimization Therapy in Stable Renal Allograft Recipients
*Purpose: African American renal transplant recipients (RTR) exhibit more immunoreactivity to allografts which may contribute to chronic rejection. This study investigated race-sex influences on ex…2019 American Transplant Congress
Use of a CMV Specific T Cell Immunity Assay in Late-Onset CMV Infection
*Purpose: To describe our clinical experience using a CMV Specific Cell Mediated Immunity (CMI) assay in solid organ transplant (SOT) recipients with late-onset CMV, defined…
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- …
- 9
- Next Page »